SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bsw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		5 / 12 LEU A 316
LEU A 456
ASN A 457
LEU A 455
THR A 319
 None
 1.11A 1a28B-5bswA:
undetectable		 1a28B-5bswA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		5 / 12 THR A  54
ALA A  56
ASP A  57
GLU A  59
LEU A  60
 None
 1.13A 1errA-5bswA:
undetectable		 1errA-5bswA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		4 / 5 ILE A 238
LEU A 341
ALA A 338
GLU A 337
 None
None
None
4UW  A 600 ( 4.6A)
 1.21A 1xvaA-5bswA:
3.3
1xvaB-5bswA:
2.3		 1xvaA-5bswA:
18.81
1xvaB-5bswA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		4 / 6 ALA A 338
GLU A 337
ILE A 238
LEU A 341
 None
4UW  A 600 ( 4.6A)
None
None
 1.04A 1xvaA-5bswA:
3.3
1xvaB-5bswA:
2.3		 1xvaA-5bswA:
18.81
1xvaB-5bswA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		5 / 12 LEU A 316
LEU A 456
ASN A 457
LEU A 455
THR A 319
 None
 1.10A 1zucB-5bswA:
undetectable		 1zucB-5bswA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		5 / 12 GLY A 101
ALA A 102
ASP A  78
ILE A 173
ALA A  93
 None
 1.06A 2b7zB-5bswA:
undetectable		 2b7zB-5bswA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		4 / 7 GLY A 339
ILE A 394
GLN A 212
LEU A 341
 4UW  A 600 ( 4.8A)
None
None
None
 0.95A 2xrhA-5bswA:
undetectable		 2xrhA-5bswA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		3 / 3 SER A 523
GLU A 337
ASP A 401
 None
4UW  A 600 ( 4.6A)
None
 0.80A 2zulA-5bswA:
undetectable		 2zulA-5bswA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		5 / 12 ILE A 288
LEU A 230
ASN A  86
MET A 258
ILE A 270
 None
 1.12A 3a50D-5bswA:
undetectable		 3a50D-5bswA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		5 / 11 LEU A 286
ILE A 526
LYS A 525
PRO A 522
SER A 523
 None
None
4UW  A 600 (-2.7A)
None
None
 1.27A 3bjwB-5bswA:
undetectable		 3bjwB-5bswA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		5 / 11 LEU A 286
ILE A 526
LYS A 525
PRO A 522
SER A 523
 None
None
4UW  A 600 (-2.7A)
None
None
 1.30A 3bjwE-5bswA:
undetectable		 3bjwE-5bswA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		5 / 11 LEU A 286
ILE A 526
LYS A 525
PRO A 522
SER A 523
 None
None
4UW  A 600 (-2.7A)
None
None
 1.24A 3bjwH-5bswA:
undetectable		 3bjwH-5bswA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		3 / 3 CYH A  31
HIS A  28
PHE A  32
 None
 1.11A 3cr4X-5bswA:
undetectable		 3cr4X-5bswA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		3 / 3 SER A 523
GLU A 337
ASP A 401
 None
4UW  A 600 ( 4.6A)
None
 0.82A 3dmhA-5bswA:
2.5		 3dmhA-5bswA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		6 / 10 LEU A  44
GLY A 252
ALA A 253
ASP A 227
ILE A 277
ILE A 255
 None
 1.48A 3ekpD-5bswA:
undetectable		 3ekpD-5bswA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		3 / 3 ASN A 457
HIS A 458
VAL A 495
 None
 0.77A 3elzB-5bswA:
undetectable		 3elzB-5bswA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		5 / 12 LEU A 267
LEU A 299
VAL A 302
ILE A 288
PHE A 280
 None
 1.14A 3fl9G-5bswA:
undetectable		 3fl9G-5bswA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		4 / 8 SER A  98
LEU A  27
TYR A  99
PHE A  32
 None
 1.03A 3i45A-5bswA:
4.9		 3i45A-5bswA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		3 / 3 ASN A  86
ASN A  46
GLU A  89
 None
 0.86A 3kpdC-5bswA:
undetectable		 3kpdC-5bswA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		3 / 3 ASN A  86
ASN A  46
GLU A  89
 None
 0.93A 3kpdB-5bswA:
undetectable		 3kpdB-5bswA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		4 / 6 ILE A 255
ASN A  86
PRO A  88
LEU A  44
 None
 1.03A 3oi8A-5bswA:
undetectable		 3oi8A-5bswA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		5 / 12 LEU A  69
VAL A  65
ILE A 257
LEU A  84
VAL A 129
 None
 1.29A 3sp9B-5bswA:
undetectable		 3sp9B-5bswA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		4 / 6 GLN A  51
TYR A  53
PHE A  92
PRO A  88
 None
 1.11A 3tgvB-5bswA:
undetectable		 3tgvB-5bswA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		4 / 6 GLN A  51
TYR A  53
PHE A  92
PRO A  88
 None
 1.16A 3tgvD-5bswA:
undetectable		 3tgvD-5bswA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		3 / 3 LYS A 396
THR A 202
ILE A 178
 None
 0.91A 4e0fB-5bswA:
undetectable		 4e0fB-5bswA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		5 / 12 LEU A 316
LEU A 456
ASN A 457
LEU A 455
THR A 319
 None
 1.11A 4fn9A-5bswA:
undetectable		 4fn9A-5bswA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		5 / 12 LEU A 316
LEU A 456
ASN A 457
LEU A 455
THR A 319
 None
 1.15A 4fn9B-5bswA:
undetectable		 4fn9B-5bswA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		3 / 3 LYS A 290
LEU A 286
ALA A 289
 None
 0.72A 4iizA-5bswA:
undetectable		 4iizA-5bswA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		4 / 8 LEU A 249
CYH A  31
TYR A  30
GLN A 213
 None
None
None
4UW  A 600 ( 4.7A)
 0.91A 4j7uD-5bswA:
3.5		 4j7uD-5bswA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		5 / 11 ILE A 394
ALA A 338
GLY A 339
GLY A 191
TYR A 398
 None
None
4UW  A 600 ( 4.8A)
4UW  A 600 ( 4.7A)
None
 1.31A 4jdsA-5bswA:
undetectable		 4jdsA-5bswA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		4 / 5 LEU A 100
GLY A 101
ILE A  80
LYS A 126
 None
 1.13A 4ma8C-5bswA:
undetectable		 4ma8C-5bswA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		4 / 8 ILE A 127
LYS A 126
ILE A  80
ALA A 102
 None
 0.73A 4ou1A-5bswA:
3.2		 4ou1A-5bswA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		3 / 3 PHE A 162
THR A 105
LEU A  69
 None
 0.76A 4qztA-5bswA:
undetectable		 4qztA-5bswA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		4 / 5 LEU A 399
TYR A 398
LEU A 186
TYR A 188
 None
 1.22A 5ki6A-5bswA:
4.1		 5ki6A-5bswA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		5 / 12 GLY A 385
ILE A 420
TYR A 416
THR A 417
LEU A 438
 None
 1.47A 5nz0A-5bswA:
undetectable		 5nz0A-5bswA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		4 / 8 ILE A 394
ALA A 366
ARG A 390
ASP A   9
 None
 1.04A 6hu9a-5bswA:
undetectable
6hu9e-5bswA:
undetectable		 6hu9a-5bswA:
22.86
6hu9e-5bswA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5bsw 4-COUMARATE--COA
LIGASE 2
(Nicotiana
tabacum) 		4 / 6 ILE A 394
ALA A 366
ARG A 390
ASP A   9
 None
 1.01A 6hu9m-5bswA:
undetectable
6hu9q-5bswA:
undetectable		 6hu9m-5bswA:
22.86
6hu9q-5bswA:
13.94