SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bsz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 5bsz N-METHYLTRANSFERASE
(Streptoalloteich
us
sp.
ATCC
53650) 		4 / 5 ASP A 181
VAL A 182
SER A 183
ASP A 213
 None
 1.21A 1n2xB-5bszA:
14.2		 1n2xB-5bszA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5bsz N-METHYLTRANSFERASE
(Streptoalloteich
us
sp.
ATCC
53650) 		5 / 12 GLY A  55
THR A  56
SER A  76
MET A  79
SER A 115
 SAH  A 301 ( 3.7A)
None
SAH  A 301 (-4.6A)
SAH  A 301 ( 4.4A)
SAH  A 301 (-3.5A)
 0.83A 1nbiC-5bszA:
20.9		 1nbiC-5bszA:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5bsz N-METHYLTRANSFERASE
(Streptoalloteich
us
sp.
ATCC
53650) 		5 / 12 GLY A  55
THR A  56
SER A  76
MET A  79
SER A 115
 SAH  A 301 ( 3.7A)
None
SAH  A 301 (-4.6A)
SAH  A 301 ( 4.4A)
SAH  A 301 (-3.5A)
 0.81A 1nbiD-5bszA:
20.9		 1nbiD-5bszA:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 5bsz N-METHYLTRANSFERASE
(Streptoalloteich
us
sp.
ATCC
53650) 		3 / 3 ASP A 145
HIS A  59
ASP A  51
 None
SAH  A 301 (-4.2A)
SAH  A 301 ( 4.7A)
 0.86A 1nw5A-5bszA:
3.3		 1nw5A-5bszA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 5bsz N-METHYLTRANSFERASE
(Streptoalloteich
us
sp.
ATCC
53650) 		5 / 12 LEU A 218
LEU A 215
LEU A 228
THR A 229
LEU A 238
 None
 0.97A 2bdmA-5bszA:
undetectable		 2bdmA-5bszA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 5bsz N-METHYLTRANSFERASE
(Streptoalloteich
us
sp.
ATCC
53650) 		5 / 12 ALA A  95
GLY A  55
THR A  56
GLU A  74
LEU A  75
 EDO  A 304 (-4.5A)
SAH  A 301 ( 3.7A)
None
SAH  A 301 (-2.9A)
SAH  A 301 (-3.9A)
 1.15A 2zifA-5bszA:
3.2		 2zifA-5bszA:
23.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 5bsz N-METHYLTRANSFERASE
(Streptoalloteich
us
sp.
ATCC
53650) 		8 / 12 ALA A  53
GLY A  55
HIS A  59
LEU A  75
SER A  76
MET A  79
MET A  97
SER A 115
 SAH  A 301 (-3.3A)
SAH  A 301 ( 3.7A)
SAH  A 301 (-4.2A)
SAH  A 301 (-3.9A)
SAH  A 301 (-4.6A)
SAH  A 301 ( 4.4A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.5A)
 0.64A 3bxoA-5bszA:
30.6		 3bxoA-5bszA:
50.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 5bsz N-METHYLTRANSFERASE
(Streptoalloteich
us
sp.
ATCC
53650) 		8 / 12 ALA A  53
GLY A  55
HIS A  59
LEU A  75
SER A  76
MET A  79
SER A 115
TYR A 118
 SAH  A 301 (-3.3A)
SAH  A 301 ( 3.7A)
SAH  A 301 (-4.2A)
SAH  A 301 (-3.9A)
SAH  A 301 (-4.6A)
SAH  A 301 ( 4.4A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.7A)
 0.76A 3bxoA-5bszA:
30.6		 3bxoA-5bszA:
50.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 5bsz N-METHYLTRANSFERASE
(Streptoalloteich
us
sp.
ATCC
53650) 		8 / 12 ALA A  53
GLY A  55
HIS A  59
LEU A  75
SER A  76
MET A  79
MET A  97
SER A 115
 SAH  A 301 (-3.3A)
SAH  A 301 ( 3.7A)
SAH  A 301 (-4.2A)
SAH  A 301 (-3.9A)
SAH  A 301 (-4.6A)
SAH  A 301 ( 4.4A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.5A)
 0.59A 3bxoB-5bszA:
30.6		 3bxoB-5bszA:
50.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 5bsz N-METHYLTRANSFERASE
(Streptoalloteich
us
sp.
ATCC
53650) 		7 / 12 GLY A  55
HIS A  59
LEU A  75
SER A  76
MET A  79
SER A 115
TYR A 118
 SAH  A 301 ( 3.7A)
SAH  A 301 (-4.2A)
SAH  A 301 (-3.9A)
SAH  A 301 (-4.6A)
SAH  A 301 ( 4.4A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.7A)
 0.81A 3bxoB-5bszA:
30.6		 3bxoB-5bszA:
50.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 5bsz N-METHYLTRANSFERASE
(Streptoalloteich
us
sp.
ATCC
53650) 		6 / 12 ALA A  53
GLY A  55
LEU A  75
SER A  76
MET A  97
SER A 115
 SAH  A 301 (-3.3A)
SAH  A 301 ( 3.7A)
SAH  A 301 (-3.9A)
SAH  A 301 (-4.6A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.5A)
 0.56A 3g2oA-5bszA:
18.4		 3g2oA-5bszA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 5bsz N-METHYLTRANSFERASE
(Streptoalloteich
us
sp.
ATCC
53650) 		6 / 12 ALA A  53
LEU A  75
SER A  76
MET A  97
GLY A 114
SER A 115
 SAH  A 301 (-3.3A)
SAH  A 301 (-3.9A)
SAH  A 301 (-4.6A)
SAH  A 301 (-3.8A)
None
SAH  A 301 (-3.5A)
 0.99A 3g2oA-5bszA:
18.4		 3g2oA-5bszA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 5bsz N-METHYLTRANSFERASE
(Streptoalloteich
us
sp.
ATCC
53650) 		6 / 12 ALA A  53
GLY A  55
LEU A  75
ASP A  96
MET A  97
SER A 115
 SAH  A 301 (-3.3A)
SAH  A 301 ( 3.7A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.7A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.5A)
 0.56A 3g2oB-5bszA:
19.1		 3g2oB-5bszA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 5bsz N-METHYLTRANSFERASE
(Streptoalloteich
us
sp.
ATCC
53650) 		6 / 12 ALA A  53
LEU A  75
ASP A  96
MET A  97
GLY A 114
SER A 115
 SAH  A 301 (-3.3A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.7A)
SAH  A 301 (-3.8A)
None
SAH  A 301 (-3.5A)
 0.93A 3g2oB-5bszA:
19.1		 3g2oB-5bszA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5bsz N-METHYLTRANSFERASE
(Streptoalloteich
us
sp.
ATCC
53650) 		5 / 12 ALA A  53
GLY A  55
SER A  76
MET A  79
ASP A  96
 SAH  A 301 (-3.3A)
SAH  A 301 ( 3.7A)
SAH  A 301 (-4.6A)
SAH  A 301 ( 4.4A)
SAH  A 301 (-3.7A)
 0.73A 3ou6A-5bszA:
15.5		 3ou6A-5bszA:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5bsz N-METHYLTRANSFERASE
(Streptoalloteich
us
sp.
ATCC
53650) 		5 / 12 ALA A  53
GLY A  55
SER A  76
MET A  79
ASP A  96
 SAH  A 301 (-3.3A)
SAH  A 301 ( 3.7A)
SAH  A 301 (-4.6A)
SAH  A 301 ( 4.4A)
SAH  A 301 (-3.7A)
 0.75A 3ou7A-5bszA:
15.8		 3ou7A-5bszA:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5bsz N-METHYLTRANSFERASE
(Streptoalloteich
us
sp.
ATCC
53650) 		5 / 12 ALA A  53
GLY A  55
SER A  76
MET A  79
ASP A  96
 SAH  A 301 (-3.3A)
SAH  A 301 ( 3.7A)
SAH  A 301 (-4.6A)
SAH  A 301 ( 4.4A)
SAH  A 301 (-3.7A)
 0.75A 3ou7D-5bszA:
15.5		 3ou7D-5bszA:
26.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 5bsz N-METHYLTRANSFERASE
(Streptoalloteich
us
sp.
ATCC
53650) 		9 / 12 ALA A  53
GLY A  55
HIS A  59
LEU A  75
SER A  76
MET A  79
ASP A  96
MET A  97
SER A 115
 SAH  A 301 (-3.3A)
SAH  A 301 ( 3.7A)
SAH  A 301 (-4.2A)
SAH  A 301 (-3.9A)
SAH  A 301 (-4.6A)
SAH  A 301 ( 4.4A)
SAH  A 301 (-3.7A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.5A)
 0.72A 3pfgA-5bszA:
32.3		 3pfgA-5bszA:
42.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 5bsz N-METHYLTRANSFERASE
(Streptoalloteich
us
sp.
ATCC
53650) 		4 / 6 GLY A  55
THR A  56
GLU A  74
ASP A  51
 SAH  A 301 ( 3.7A)
None
SAH  A 301 (-2.9A)
SAH  A 301 ( 4.7A)
 0.99A 3ps9A-5bszA:
4.7		 3ps9A-5bszA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 5bsz N-METHYLTRANSFERASE
(Streptoalloteich
us
sp.
ATCC
53650) 		4 / 6 GLY A  55
GLU A  74
ASP A  96
ASP A  51
 SAH  A 301 ( 3.7A)
SAH  A 301 (-2.9A)
SAH  A 301 (-3.7A)
SAH  A 301 ( 4.7A)
 0.95A 3vywC-5bszA:
10.8		 3vywC-5bszA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5bsz N-METHYLTRANSFERASE
(Streptoalloteich
us
sp.
ATCC
53650) 		4 / 8 VAL A 182
ARG A 184
ILE A 179
GLU A 124
 None
EDO  A 302 ( 4.4A)
None
None
 1.02A 4a97I-5bszA:
undetectable		 4a97I-5bszA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 5bsz N-METHYLTRANSFERASE
(Streptoalloteich
us
sp.
ATCC
53650) 		4 / 6 ARG A 184
HIS A 185
LEU A 208
ASP A 205
 EDO  A 302 ( 4.4A)
THM  A 306 (-4.4A)
None
EDO  A 302 (-3.4A)
 1.06A 4cevA-5bszA:
4.2
4cevB-5bszA:
3.0		 4cevA-5bszA:
25.87
4cevB-5bszA:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 5bsz N-METHYLTRANSFERASE
(Streptoalloteich
us
sp.
ATCC
53650) 		4 / 6 ASP A 205
ARG A 184
HIS A 185
LEU A 208
 EDO  A 302 (-3.4A)
EDO  A 302 ( 4.4A)
THM  A 306 (-4.4A)
None
 1.05A 4cevA-5bszA:
4.3
4cevC-5bszA:
4.3		 4cevA-5bszA:
25.87
4cevC-5bszA:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 5bsz N-METHYLTRANSFERASE
(Streptoalloteich
us
sp.
ATCC
53650) 		4 / 6 ARG A 184
HIS A 185
LEU A 208
ASP A 205
 EDO  A 302 ( 4.4A)
THM  A 306 (-4.4A)
None
EDO  A 302 (-3.4A)
 1.02A 4cevD-5bszA:
4.4
4cevE-5bszA:
4.5		 4cevD-5bszA:
25.87
4cevE-5bszA:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 5bsz N-METHYLTRANSFERASE
(Streptoalloteich
us
sp.
ATCC
53650) 		4 / 6 ARG A 184
HIS A 185
LEU A 208
ASP A 205
 EDO  A 302 ( 4.4A)
THM  A 306 (-4.4A)
None
EDO  A 302 (-3.4A)
 1.03A 4cevE-5bszA:
4.3
4cevF-5bszA:
4.7		 4cevE-5bszA:
25.87
4cevF-5bszA:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5bsz N-METHYLTRANSFERASE
(Streptoalloteich
us
sp.
ATCC
53650) 		4 / 8 ARG A 243
ALA A 133
LEU A 142
GLY A 241
 None
 0.96A 4xk8a-5bszA:
undetectable		 4xk8a-5bszA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 5bsz N-METHYLTRANSFERASE
(Streptoalloteich
us
sp.
ATCC
53650) 		5 / 12 ALA A  53
GLY A  55
SER A  76
MET A  79
SER A 115
 SAH  A 301 (-3.3A)
SAH  A 301 ( 3.7A)
SAH  A 301 (-4.6A)
SAH  A 301 ( 4.4A)
SAH  A 301 (-3.5A)
 0.64A 5gwxA-5bszA:
19.8		 5gwxA-5bszA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5bsz N-METHYLTRANSFERASE
(Streptoalloteich
us
sp.
ATCC
53650) 		5 / 12 ASP A  96
ALA A  95
ASP A  51
GLY A  55
GLU A  74
 SAH  A 301 (-3.7A)
EDO  A 304 (-4.5A)
SAH  A 301 ( 4.7A)
SAH  A 301 ( 3.7A)
SAH  A 301 (-2.9A)
 1.23A 5hfjF-5bszA:
2.3		 5hfjF-5bszA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 5bsz N-METHYLTRANSFERASE
(Streptoalloteich
us
sp.
ATCC
53650) 		5 / 12 GLY A  55
SER A  76
MET A  79
ASP A  96
SER A 115
 SAH  A 301 ( 3.7A)
SAH  A 301 (-4.6A)
SAH  A 301 ( 4.4A)
SAH  A 301 (-3.7A)
SAH  A 301 (-3.5A)
 0.79A 5hikA-5bszA:
20.8		 5hikA-5bszA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 5bsz N-METHYLTRANSFERASE
(Streptoalloteich
us
sp.
ATCC
53650) 		5 / 12 PHE A 239
THR A 152
ALA A 123
ALA A 216
GLU A 212
 None
 1.09A 5vcgA-5bszA:
undetectable		 5vcgA-5bszA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5bsz N-METHYLTRANSFERASE
(Streptoalloteich
us
sp.
ATCC
53650) 		4 / 7 ALA A  53
GLY A  55
GLY A  57
GLU A  74
 SAH  A 301 (-3.3A)
SAH  A 301 ( 3.7A)
None
SAH  A 301 (-2.9A)
 0.72A 5ybbB-5bszA:
9.2		 5ybbB-5bszA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 5bsz N-METHYLTRANSFERASE
(Streptoalloteich
us
sp.
ATCC
53650) 		5 / 12 GLY A 140
LEU A 142
VAL A 240
GLY A 103
ASP A 101
 None
 1.13A 6gngA-5bszA:
undetectable		 6gngA-5bszA:
17.32