SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bt1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 5bt1 HAT1-INTERACTING
FACTOR 1
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 282
GLU A 283
LEU A 263
LEU A 260
ARG A 304
 None
 1.37A 1a52A-5bt1A:
2.1		 1a52A-5bt1A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 5bt1 HAT1-INTERACTING
FACTOR 1
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 282
GLU A 283
LEU A 263
LEU A 260
ARG A 304
 None
 1.40A 1a52B-5bt1A:
undetectable		 1a52B-5bt1A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5bt1 HAT1-INTERACTING
FACTOR 1
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  41
ALA A  42
LEU A  33
ALA A  29
LEU A 202
 None
 1.01A 1fm6A-5bt1A:
undetectable		 1fm6A-5bt1A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5bt1 HAT1-INTERACTING
FACTOR 1
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  41
ALA A  42
LEU A  33
ALA A  29
ILE A 245
 None
 0.70A 1fm6U-5bt1A:
undetectable		 1fm6U-5bt1A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 5bt1 HAT1-INTERACTING
FACTOR 1
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 282
GLU A 283
LEU A 263
LEU A 260
ARG A 304
 None
 1.40A 1pcgB-5bt1A:
undetectable		 1pcgB-5bt1A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5bt1 HAT1-INTERACTING
FACTOR 1
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  41
ALA A  42
LEU A  33
ALA A  29
ILE A 245
 None
 0.64A 2aclA-5bt1A:
undetectable
2aclE-5bt1A:
undetectable		 2aclA-5bt1A:
22.68
2aclE-5bt1A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 5bt1 HAT1-INTERACTING
FACTOR 1
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 260
VAL A 293
ALA A 289
LEU A 290
ARG A 304
 None
 1.28A 2bxgA-5bt1A:
3.9		 2bxgA-5bt1A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5bt1 HAT1-INTERACTING
FACTOR 1
(Saccharomyces
cerevisiae) 		5 / 10 ALA A  41
ALA A  42
LEU A  33
ALA A  29
ILE A 245
 None
 0.68A 3falC-5bt1A:
2.2		 3falC-5bt1A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5bt1 HAT1-INTERACTING
FACTOR 1
(Saccharomyces
cerevisiae) 		5 / 11 ALA A  41
ALA A  42
LEU A  33
ALA A  29
ILE A 245
 None
 0.78A 3fc6A-5bt1A:
undetectable		 3fc6A-5bt1A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5bt1 HAT1-INTERACTING
FACTOR 1
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  41
ALA A  42
LEU A  33
ALA A  29
ILE A 245
 None
 0.93A 3h0aA-5bt1A:
undetectable		 3h0aA-5bt1A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEG_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 5bt1 HAT1-INTERACTING
FACTOR 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 207
ASN A 205
VAL A  71
TYR A  72
LEU A 210
 None
 1.50A 3megA-5bt1A:
undetectable		 3megA-5bt1A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 5bt1 HAT1-INTERACTING
FACTOR 1
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 182
LYS A 261
TYR A 259
HIS A 258
 None
 1.45A 4uciB-5bt1A:
undetectable		 4uciB-5bt1A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5bt1 HAT1-INTERACTING
FACTOR 1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A  38
MET A  74
LEU A  32
LEU A  33
 None
 1.15A 5dzke-5bt1A:
undetectable
5dzks-5bt1A:
undetectable		 5dzke-5bt1A:
20.88
5dzks-5bt1A:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 5bt1 HAT1-INTERACTING
FACTOR 1
(Saccharomyces
cerevisiae) 		3 / 3 ILE A  66
MET A 215
ASP A  60
 None
 0.79A 5h2uA-5bt1A:
undetectable		 5h2uA-5bt1A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 5bt1 HAT1-INTERACTING
FACTOR 1
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 282
GLU A 283
LEU A 263
LEU A 260
ARG A 304
 None
 1.38A 5hyrB-5bt1A:
undetectable		 5hyrB-5bt1A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5bt1 HAT1-INTERACTING
FACTOR 1
(Saccharomyces
cerevisiae) 		6 / 12 ALA A  41
ALA A  42
LEU A  33
ALA A  29
ILE A 245
LEU A 202
 None
 0.86A 6a5yD-5bt1A:
undetectable		 6a5yD-5bt1A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5bt1 HAT1-INTERACTING
FACTOR 1
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  41
ALA A  42
LEU A  33
ALA A  29
ILE A 245
 None
 0.63A 6a5zD-5bt1A:
undetectable		 6a5zD-5bt1A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5bt1 HAT1-INTERACTING
FACTOR 1
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  41
ALA A  42
LEU A  33
ALA A  29
ILE A 245
 None
 0.62A 6a5zL-5bt1A:
undetectable		 6a5zL-5bt1A:
12.66