SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bth'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)
5bth DECAPPING NUCLEASE
RAI1

(Candida
albicans)
5 / 12 LEU A 350
LEU A 122
MET A 106
LEU A   5
THR A 338
None
1.19A 1zucB-5bthA:
undetectable
1zucB-5bthA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)
5bth DECAPPING NUCLEASE
RAI1

(Candida
albicans)
5 / 12 ILE A 120
LEU A 273
ARG A  10
THR A 101
LEU A 335
None
0.98A 2w3bA-5bthA:
undetectable
2w3bA-5bthA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)
5bth DECAPPING NUCLEASE
RAI1

(Candida
albicans)
5 / 11 ILE A 120
PHE A 359
SER A 358
VAL A 125
LEU A 131
None
1.12A 3a9eB-5bthA:
undetectable
3a9eB-5bthA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)
5bth DECAPPING NUCLEASE
RAI1

(Candida
albicans)
3 / 3 ASP A 121
GLU A 146
SER A 362
None
0.81A 3p2kA-5bthA:
undetectable
3p2kA-5bthA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)
5bth DECAPPING NUCLEASE
RAI1

(Candida
albicans)
4 / 6 CYH A 321
THR A 322
ASN A 320
ILE A 303
None
1.44A 3w9tB-5bthA:
undetectable
3w9tB-5bthA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)
5bth DECAPPING NUCLEASE
RAI1

(Candida
albicans)
5 / 12 ILE A 120
LEU A 273
THR A 101
ILE A  99
LEU A 335
None
1.02A 4kebB-5bthA:
undetectable
4kebB-5bthA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)
5bth DECAPPING NUCLEASE
RAI1

(Candida
albicans)
4 / 8 ILE A 305
LYS A 306
ILE A 319
ASN A 320
None
0.93A 4ou1A-5bthA:
undetectable
4ou1A-5bthA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
5bth DECAPPING NUCLEASE
RAI1

(Candida
albicans)
5 / 12 ILE A  85
LEU A 378
PHE A 382
ILE A 100
ILE A  84
None
1.14A 4ptjA-5bthA:
undetectable
4ptjA-5bthA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
5bth DECAPPING NUCLEASE
RAI1

(Candida
albicans)
5 / 12 ILE A  85
LEU A 378
PHE A 382
ILE A 100
ILE A  84
None
1.10A 5e8qA-5bthA:
undetectable
5e8qA-5bthA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)
5bth DECAPPING NUCLEASE
RAI1

(Candida
albicans)
5 / 12 LEU A   7
TRP A 334
LEU A 335
ILE A 105
LEU A 122
None
1.24A 5ienB-5bthA:
undetectable
5ienB-5bthA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)
5bth DECAPPING NUCLEASE
RAI1

(Candida
albicans)
4 / 7 ILE A 120
PHE A 359
TRP A 327
SER A   9
None
1.34A 5nr3A-5bthA:
undetectable
5nr3A-5bthA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
5bth DECAPPING NUCLEASE
RAI1

(Candida
albicans)
5 / 9 LEU A 112
ILE A 213
GLY A 212
LEU A 218
PHE A 359
None
0.78A 5vkqC-5bthA:
undetectable
5vkqD-5bthA:
undetectable
5vkqC-5bthA:
12.46
5vkqD-5bthA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)
5bth DECAPPING NUCLEASE
RAI1

(Candida
albicans)
3 / 3 HIS A 241
ASN A 240
LEU A 239
None
0.83A 6f7lB-5bthA:
undetectable
6f7lB-5bthA:
21.80