SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5btr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		3 / 3 ASP A 334
LEU A 340
LEU A 339
 None
 0.80A 1np1B-5btrA:
undetectable		 1np1B-5btrA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 6 ALA A 262
SER A 265
ASN A 346
ILE A 347
ASP A 348
 None
 0.21A 1yc2A-5btrA:
23.7		 1yc2A-5btrA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 5 ALA A 262
ASN A 346
ILE A 347
ASP A 348
 None
 0.34A 1yc2D-5btrA:
23.7		 1yc2D-5btrA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 7 ILE A 270
ASN A 346
ILE A 347
ASP A 348
 None
 0.28A 1yc2E-5btrA:
20.5		 1yc2E-5btrA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		6 / 7 ALA A 262
SER A 265
ILE A 270
ASN A 346
ILE A 347
ASP A 348
 None
 0.29A 1yc5A-5btrA:
20.7		 1yc5A-5btrA:
29.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 7 PHE A 287
PRO A 288
ASP A 289
TYR A 301
 None
 0.88A 2aouB-5btrA:
2.3		 2aouB-5btrA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 5 ALA A 262
ILE A 270
ASN A 346
ILE A 347
ASP A 348
 None
 0.37A 2h4jA-5btrA:
20.3		 2h4jA-5btrA:
29.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 12 PHE A 321
ILE A 270
PHE A 309
VAL A 383
ILE A 387
 None
 1.37A 3em0B-5btrA:
undetectable		 3em0B-5btrA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 11 VAL A 264
PHE A 273
PHE A 297
GLY A 364
GLU A 351
 None
 1.48A 3owxA-5btrA:
4.8
3owxB-5btrA:
4.9		 3owxA-5btrA:
21.20
3owxB-5btrA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 5 PHE A 187
ILE A 153
GLY A 149
HIS A 191
 None
 1.29A 3r0lD-5btrA:
undetectable		 3r0lD-5btrA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 10 PHE A 302
PHE A 413
ALA A 369
ILE A 387
PHE A 310
 None
 1.33A 3t3qA-5btrA:
undetectable		 3t3qA-5btrA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 10 PHE A 302
PHE A 413
ALA A 369
ILE A 387
PHE A 310
 None
 1.36A 3t3qC-5btrA:
undetectable		 3t3qC-5btrA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 8 PHE A 273
ALA A 313
PHE A 312
THR A 349
 None
 0.92A 3t3sD-5btrA:
undetectable		 3t3sD-5btrA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 8 GLN A 345
HIS A 363
VAL A 448
ARG A 274
 None
 1.07A 3uy4A-5btrA:
undetectable		 3uy4A-5btrA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 12 SER A 333
LEU A 339
ILE A 464
ILE A 437
LEU A 435
 None
 1.07A 3w67B-5btrA:
undetectable		 3w67B-5btrA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		3 / 3 TYR A 650
THR A 242
GLU A 488
 None
 0.79A 4df3A-5btrA:
undetectable		 4df3A-5btrA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		3 / 3 TYR A 650
THR A 242
GLU A 488
 None
 0.77A 4df3B-5btrA:
5.6		 4df3B-5btrA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 11 ALA A 262
GLY A 263
ASN A 342
ASN A 346
HIS A 363
 None
 1.28A 4e47A-5btrA:
undetectable		 4e47A-5btrA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 11 ALA A 262
GLY A 263
ASN A 342
ASN A 346
HIS A 363
 None
 1.29A 4e47B-5btrA:
undetectable		 4e47B-5btrA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 11 ALA A 262
GLY A 263
ASN A 342
ASN A 346
HIS A 363
 None
 1.27A 4e47C-5btrA:
undetectable		 4e47C-5btrA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 11 ALA A 262
GLY A 263
ASN A 342
ASN A 346
HIS A 363
 None
 1.32A 4jdsB-5btrA:
undetectable		 4jdsB-5btrA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 5 LYS A 499
LEU A 500
GLU A 496
LEU A 332
 None
 1.34A 4k4yA-5btrA:
undetectable		 4k4yA-5btrA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 4 LYS A 499
LEU A 500
GLU A 496
LEU A 332
 None
 1.38A 4k4yE-5btrA:
undetectable		 4k4yE-5btrA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 5 LYS A 499
LEU A 500
GLU A 496
LEU A 332
 None
 1.34A 4k4yI-5btrA:
undetectable		 4k4yI-5btrA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 5 GLY A 654
ASP A 481
GLU A 467
VAL A 438
 None
 1.13A 4nkvD-5btrA:
undetectable		 4nkvD-5btrA:
22.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 5 PHE A 297
HIS A 363
LEU A 418
PRO A 447
 None
 0.82A 4o8zA-5btrA:
28.5		 4o8zA-5btrA:
32.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 7 ILE A 270
ASN A 346
ILE A 347
ASP A 348
 None
 0.32A 4rmjA-5btrA:
29.1		 4rmjA-5btrA:
32.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 11 GLY A 355
ASP A 348
ILE A 347
ASN A 346
TYR A 317
 None
 1.31A 4rtrA-5btrA:
undetectable		 4rtrA-5btrA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 5 GLU A 351
THR A 260
HIS A 491
LEU A 325
 None
 1.29A 5axaA-5btrA:
4.0		 5axaA-5btrA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 5 GLU A 351
THR A 260
HIS A 491
LEU A 325
 None
 1.30A 5axaC-5btrA:
3.9		 5axaC-5btrA:
21.98