SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5btx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5btx LPG1496
(Legionella
pneumophila) 		5 / 12 LEU A  16
GLY A  67
ILE A  18
VAL A  47
LEU A  46
 None
 0.89A 1uakA-5btxA:
undetectable		 1uakA-5btxA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5btx LPG1496
(Legionella
pneumophila) 		5 / 12 ILE A  89
LEU A  85
GLY A  67
ASN A  64
ILE A  56
 None
 0.94A 4o1eB-5btxA:
undetectable		 4o1eB-5btxA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 5btx LPG1496
(Legionella
pneumophila) 		6 / 12 PHE A  44
GLY A  67
ILE A  56
LEU A  85
PHE A  88
LEU A  90
 None
 1.39A 4pd4C-5btxA:
undetectable		 4pd4C-5btxA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_K_IPHK101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5btx LPG1496
(Legionella
pneumophila) 		4 / 6 VAL A  95
HIS A  99
HIS A 112
LEU A 116
 None
 1.06A 5hrqH-5btxA:
undetectable
5hrqK-5btxA:
undetectable
5hrqL-5btxA:
undetectable		 5hrqH-5btxA:
13.56
5hrqK-5btxA:
12.50
5hrqL-5btxA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 5btx LPG1496
(Legionella
pneumophila) 		5 / 12 ILE A 102
HIS A 106
ASN A 107
SER A  71
TYR A  69
 None
CMP  A 201 (-3.9A)
CMP  A 201 ( 4.2A)
None
CMP  A 201 (-3.6A)
 1.48A 6chgC-5btxA:
undetectable		 6chgC-5btxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5btx LPG1496
(Legionella
pneumophila) 		6 / 12 PHE A  29
VAL A  33
VAL A  93
THR A 108
ALA A  77
TYR A  61
 None
None
None
CMP  A 201 (-3.2A)
None
CMP  A 201 (-3.6A)
 1.49A 6djzC-5btxA:
undetectable		 6djzC-5btxA:
17.11