SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bty'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 5bty LPG1496
(Legionella
pneumophila) 		5 / 10 LEU A 256
LEU A 250
VAL A 252
ILE A 170
PHE A 272
 None
 1.15A 2w9gA-5btyA:
undetectable		 2w9gA-5btyA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 5bty LPG1496
(Legionella
pneumophila) 		5 / 10 LEU A 256
LEU A 250
VAL A 252
ILE A 235
PHE A 272
 None
 1.13A 2w9hA-5btyA:
undetectable		 2w9hA-5btyA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 5bty LPG1496
(Legionella
pneumophila) 		5 / 10 ILE A 213
ALA A 161
VAL A 211
LEU A 250
PHE A 183
 None
 1.11A 3ay0A-5btyA:
undetectable		 3ay0A-5btyA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5bty LPG1496
(Legionella
pneumophila) 		3 / 3 SER A 193
ASP A 189
ASP A 241
 None
 0.65A 3iv6A-5btyA:
undetectable		 3iv6A-5btyA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5bty LPG1496
(Legionella
pneumophila) 		3 / 3 SER A 193
ASP A 189
ASP A 241
 None
 0.59A 3iv6C-5btyA:
undetectable		 3iv6C-5btyA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 5bty LPG1496
(Legionella
pneumophila) 		4 / 5 PRO A 260
THR A 261
ASN A 267
LYS A 262
 None
 1.09A 5x23A-5btyA:
undetectable		 5x23A-5btyA:
16.48