SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bu1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5bu1 LPG1496
(Legionella
pneumophila) 		4 / 5 ILE A 547
ARG A 373
ASP A 351
ASN A 347
 None
 1.43A 1kiaD-5bu1A:
undetectable		 1kiaD-5bu1A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5bu1 LPG1496
(Legionella
pneumophila) 		3 / 3 ARG A 373
ASP A 351
ASN A 347
 None
 0.83A 1nbhA-5bu1A:
undetectable		 1nbhA-5bu1A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5bu1 LPG1496
(Legionella
pneumophila) 		3 / 3 ARG A 373
ASP A 351
ASN A 347
 None
 0.80A 1nbhD-5bu1A:
undetectable		 1nbhD-5bu1A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5bu1 LPG1496
(Legionella
pneumophila) 		4 / 4 ILE A 547
ARG A 373
ASP A 351
ASN A 347
 None
 1.29A 1nbiC-5bu1A:
undetectable		 1nbiC-5bu1A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5bu1 LPG1496
(Legionella
pneumophila) 		4 / 4 ILE A 547
ARG A 373
ASP A 351
ASN A 347
 None
 1.29A 1nbiD-5bu1A:
undetectable		 1nbiD-5bu1A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_A_CHCA1001_2
(BILE ACID RECEPTOR)		 5bu1 LPG1496
(Legionella
pneumophila) 		4 / 4 MET A 409
MET A 500
ALA A 501
HIS A 504
 None
 1.04A 1ot7A-5bu1A:
0.0		 1ot7A-5bu1A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 5bu1 LPG1496
(Legionella
pneumophila) 		5 / 12 GLY A 488
HIS A 504
LEU A 354
VAL A 361
LEU A 317
 None
 1.19A 1r30B-5bu1A:
undetectable		 1r30B-5bu1A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 5bu1 LPG1496
(Legionella
pneumophila) 		4 / 8 ASP A 552
PHE A 568
LEU A 354
ASP A 351
 None
 1.06A 1rmtD-5bu1A:
undetectable		 1rmtD-5bu1A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 5bu1 LPG1496
(Legionella
pneumophila) 		5 / 12 ILE A 547
VAL A 548
PHE A 517
TYR A 542
LEU A 377
 None
 1.30A 1wsvA-5bu1A:
undetectable		 1wsvA-5bu1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 5bu1 LPG1496
(Legionella
pneumophila) 		5 / 12 ILE A 547
VAL A 548
PHE A 517
TYR A 542
LEU A 377
 None
 1.32A 1wsvB-5bu1A:
undetectable		 1wsvB-5bu1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 5bu1 LPG1496
(Legionella
pneumophila) 		3 / 3 ASN A 355
ASP A 351
GLN A 350
 None
 0.70A 3eeyC-5bu1A:
undetectable		 3eeyC-5bu1A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 5bu1 LPG1496
(Legionella
pneumophila) 		3 / 3 ASN A 355
ASP A 351
GLN A 350
 None
 0.68A 3eeyD-5bu1A:
undetectable		 3eeyD-5bu1A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 5bu1 LPG1496
(Legionella
pneumophila) 		3 / 3 ASN A 355
ASP A 351
GLN A 350
 None
 0.70A 3eeyE-5bu1A:
undetectable		 3eeyE-5bu1A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 5bu1 LPG1496
(Legionella
pneumophila) 		5 / 12 LEU A 499
GLY A 497
ILE A 381
LEU A 506
ASP A 505
 None
 1.01A 3gwvA-5bu1A:
undetectable		 3gwvA-5bu1A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5bu1 LPG1496
(Legionella
pneumophila) 		3 / 3 TYR A 445
HIS A 366
ARG A 416
 None
 0.99A 4htfA-5bu1A:
undetectable		 4htfA-5bu1A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 5bu1 LPG1496
(Legionella
pneumophila) 		5 / 12 LEU A 397
ILE A 498
ILE A 402
ALA A 405
ILE A 381
 None
 1.14A 4rp8C-5bu1A:
undetectable		 4rp8C-5bu1A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 5bu1 LPG1496
(Legionella
pneumophila) 		4 / 5 HIS A 366
HIS A 370
HIS A 504
VAL A 413
 None
 1.38A 5i3bB-5bu1A:
undetectable		 5i3bB-5bu1A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5bu1 LPG1496
(Legionella
pneumophila) 		4 / 8 HIS A 443
HIS A 366
ASP A 424
GLU A 343
 None
 1.19A 6mn4A-5bu1A:
undetectable		 6mn4A-5bu1A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5bu1 LPG1496
(Legionella
pneumophila) 		4 / 7 HIS A 443
HIS A 366
ASP A 424
GLU A 343
 None
 1.17A 6mn4F-5bu1A:
undetectable		 6mn4F-5bu1A:
22.77