SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bu2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5bu2 LPG1496
(Legionella
pneumophila) 		3 / 3 ARG A 373
ASP A 351
ASN A 347
 None
 0.96A 1nbhA-5bu2A:
undetectable		 1nbhA-5bu2A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5bu2 LPG1496
(Legionella
pneumophila) 		3 / 3 ARG A 373
ASP A 351
ASN A 347
 None
 0.95A 1nbhD-5bu2A:
undetectable		 1nbhD-5bu2A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5bu2 LPG1496
(Legionella
pneumophila) 		4 / 4 ILE A 547
ARG A 373
ASP A 351
ASN A 347
 None
 1.44A 1nbiD-5bu2A:
undetectable		 1nbiD-5bu2A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_A_CHCA1001_2
(BILE ACID RECEPTOR)		 5bu2 LPG1496
(Legionella
pneumophila) 		4 / 4 MET A 409
MET A 500
ALA A 501
HIS A 504
 None
None
None
ADP  A 702 (-3.5A)
 1.15A 1ot7A-5bu2A:
2.3		 1ot7A-5bu2A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 5bu2 LPG1496
(Legionella
pneumophila) 		4 / 8 ASP A 552
PHE A 568
LEU A 354
ASP A 351
 None
 1.03A 1rmtD-5bu2A:
undetectable		 1rmtD-5bu2A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 5bu2 LPG1496
(Legionella
pneumophila) 		5 / 12 ILE A 547
VAL A 548
PHE A 517
TYR A 542
LEU A 377
 None
 1.26A 1wsvA-5bu2A:
undetectable		 1wsvA-5bu2A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 5bu2 LPG1496
(Legionella
pneumophila) 		3 / 3 TRP A 336
GLN A 350
TRP A 422
 None
 1.35A 2vqyA-5bu2A:
undetectable		 2vqyA-5bu2A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 5bu2 LPG1496
(Legionella
pneumophila) 		3 / 3 ASN A 355
ASP A 351
GLN A 350
 None
 0.83A 3eeyC-5bu2A:
undetectable		 3eeyC-5bu2A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 5bu2 LPG1496
(Legionella
pneumophila) 		3 / 3 ASN A 355
ASP A 351
GLN A 350
 None
 0.81A 3eeyD-5bu2A:
undetectable		 3eeyD-5bu2A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 5bu2 LPG1496
(Legionella
pneumophila) 		3 / 3 ASN A 355
ASP A 351
GLN A 350
 None
 0.81A 3eeyE-5bu2A:
undetectable		 3eeyE-5bu2A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 5bu2 LPG1496
(Legionella
pneumophila) 		3 / 3 ASP A 552
ARG A 510
ASP A 562
 None
ADP  A 702 (-3.9A)
None
 0.88A 4fp9F-5bu2A:
undetectable		 4fp9F-5bu2A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5bu2 LPG1496
(Legionella
pneumophila) 		3 / 3 TYR A 445
HIS A 366
ARG A 416
 ADP  A 702 (-3.6A)
ADP  A 702 (-4.2A)
ADP  A 702 (-3.4A)
 0.98A 4htfA-5bu2A:
undetectable		 4htfA-5bu2A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5bu2 LPG1496
(Legionella
pneumophila) 		5 / 12 LEU A 300
ALA A 375
SER A 412
ILE A 309
LEU A 467
 None
None
ADP  A 702 (-4.9A)
None
None
 1.14A 5h8tA-5bu2A:
undetectable		 5h8tA-5bu2A:
16.30