SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5buk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 5buk FADH2-DEPENDENT
HALOGENASE
(Streptomyces
sp.
CNQ-418) 		5 / 12 PHE A 383
LEU A 379
PHE A  90
LEU A 400
PHE A 372
 None
 1.21A 1og5A-5bukA:
undetectable		 1og5A-5bukA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 5buk FADH2-DEPENDENT
HALOGENASE
(Streptomyces
sp.
CNQ-418) 		4 / 7 GLY A  11
GLY A  12
VAL A 146
SER A 178
 FAD  A 501 (-3.3A)
FAD  A 501 ( 4.9A)
FAD  A 501 (-4.0A)
FAD  A 501 (-4.6A)
 0.59A 2oa1B-5bukA:
23.2		 2oa1B-5bukA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5buk FADH2-DEPENDENT
HALOGENASE
(Streptomyces
sp.
CNQ-418) 		4 / 7 GLY A  11
THR A  19
GLU A  34
ALA A 177
 FAD  A 501 (-3.3A)
None
FAD  A 501 (-2.8A)
None
 0.86A 3fpjB-5bukA:
2.5		 3fpjB-5bukA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 5buk FADH2-DEPENDENT
HALOGENASE
(Streptomyces
sp.
CNQ-418) 		3 / 3 MET A 416
MET A  88
PHE A 383
 None
 1.26A 3gn8A-5bukA:
undetectable		 3gn8A-5bukA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5buk FADH2-DEPENDENT
HALOGENASE
(Streptomyces
sp.
CNQ-418) 		3 / 3 PRO A 290
LEU A 291
GLN A 287
 None
 0.56A 3hznG-5bukA:
undetectable
3hznH-5bukA:
undetectable		 3hznG-5bukA:
21.43
3hznH-5bukA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 5buk FADH2-DEPENDENT
HALOGENASE
(Streptomyces
sp.
CNQ-418) 		4 / 6 PHE A 197
ASP A 233
TYR A 377
PRO A 195
 None
 1.49A 3jqaB-5bukA:
3.9		 3jqaB-5bukA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5buk FADH2-DEPENDENT
HALOGENASE
(Streptomyces
sp.
CNQ-418) 		5 / 10 ILE A  10
ALA A 315
SER A 338
ILE A 341
ILE A   9
 FAD  A 501 (-4.7A)
None
None
None
None
 1.30A 3qgtA-5bukA:
undetectable		 3qgtA-5bukA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5buk FADH2-DEPENDENT
HALOGENASE
(Streptomyces
sp.
CNQ-418) 		4 / 4 GLY A  13
GLY A  16
THR A  18
LEU A 331
 FAD  A 501 (-3.4A)
None
None
None
 0.91A 3si7C-5bukA:
undetectable
3si7D-5bukA:
undetectable		 3si7C-5bukA:
20.82
3si7D-5bukA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 5buk FADH2-DEPENDENT
HALOGENASE
(Streptomyces
sp.
CNQ-418) 		3 / 3 GLN A 199
PHE A 197
TYR A 377
 None
 0.97A 3ucjB-5bukA:
undetectable		 3ucjB-5bukA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 5buk FADH2-DEPENDENT
HALOGENASE
(Streptomyces
sp.
CNQ-418) 		3 / 3 GLN A 199
PHE A 197
TYR A 377
 None
 1.00A 3ucjA-5bukA:
undetectable		 3ucjA-5bukA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5buk FADH2-DEPENDENT
HALOGENASE
(Streptomyces
sp.
CNQ-418) 		5 / 12 SER A  17
VAL A  48
ALA A 177
VAL A 366
VAL A  54
 None
 1.22A 4ib4A-5bukA:
undetectable		 4ib4A-5bukA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5buk FADH2-DEPENDENT
HALOGENASE
(Streptomyces
sp.
CNQ-418) 		5 / 11 SER A  35
ARG A 145
VAL A 146
ILE A  10
LEU A 184
 FAD  A 501 (-3.2A)
FAD  A 501 (-3.5A)
FAD  A 501 (-4.0A)
FAD  A 501 (-4.7A)
None
 1.49A 4k37B-5bukA:
undetectable		 4k37B-5bukA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5buk FADH2-DEPENDENT
HALOGENASE
(Streptomyces
sp.
CNQ-418) 		4 / 6 ARG A 289
ARG A 122
ASP A 121
ASP A 126
 None
FAD  A 501 (-3.0A)
None
FAD  A 501 ( 4.8A)
 1.36A 4kcnB-5bukA:
undetectable		 4kcnB-5bukA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5buk FADH2-DEPENDENT
HALOGENASE
(Streptomyces
sp.
CNQ-418) 		4 / 7 LEU A 128
ARG A  40
ARG A 122
VAL A 327
 None
FAD  A 501 (-3.8A)
FAD  A 501 (-3.0A)
FAD  A 501 (-3.7A)
 1.27A 4klrA-5bukA:
undetectable		 4klrA-5bukA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 5buk FADH2-DEPENDENT
HALOGENASE
(Streptomyces
sp.
CNQ-418) 		5 / 9 ALA A  31
ILE A  10
GLY A  11
THR A 160
VAL A 169
 None
FAD  A 501 (-4.7A)
FAD  A 501 (-3.3A)
None
None
 1.03A 4nptA-5bukA:
undetectable		 4nptA-5bukA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 5buk FADH2-DEPENDENT
HALOGENASE
(Streptomyces
sp.
CNQ-418) 		4 / 6 ALA A 344
LEU A  28
THR A  19
LEU A  23
 None
 0.79A 4o0uA-5bukA:
undetectable		 4o0uA-5bukA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 5buk FADH2-DEPENDENT
HALOGENASE
(Streptomyces
sp.
CNQ-418) 		5 / 12 VAL A  54
GLY A 179
THR A 182
GLN A 183
LEU A 184
 None
FAD  A 501 (-3.4A)
None
FAD  A 501 (-3.6A)
None
 1.10A 5hg0A-5bukA:
undetectable		 5hg0A-5bukA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 5buk FADH2-DEPENDENT
HALOGENASE
(Streptomyces
sp.
CNQ-418) 		5 / 10 ALA A 167
THR A 160
GLU A 159
ALA A 163
GLY A 164
 None
 1.19A 5lf3H-5bukA:
undetectable
5lf3I-5bukA:
undetectable		 5lf3H-5bukA:
18.02
5lf3I-5bukA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 5buk FADH2-DEPENDENT
HALOGENASE
(Streptomyces
sp.
CNQ-418) 		5 / 10 ALA A 167
THR A 160
GLU A 159
ALA A 163
GLY A 164
 None
 1.20A 5lf3V-5bukA:
undetectable
5lf3W-5bukA:
undetectable		 5lf3V-5bukA:
18.02
5lf3W-5bukA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5buk FADH2-DEPENDENT
HALOGENASE
(Streptomyces
sp.
CNQ-418) 		5 / 10 LEU A  32
HIS A 141
ILE A   9
GLY A   8
ALA A  20
 None
 0.93A 5o96C-5bukA:
undetectable
5o96D-5bukA:
undetectable		 5o96C-5bukA:
21.40
5o96D-5bukA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 5buk FADH2-DEPENDENT
HALOGENASE
(Streptomyces
sp.
CNQ-418) 		5 / 12 SER A  17
VAL A  48
ALA A 177
VAL A 366
VAL A  54
 None
 1.20A 5tudD-5bukA:
undetectable		 5tudD-5bukA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 5buk FADH2-DEPENDENT
HALOGENASE
(Streptomyces
sp.
CNQ-418) 		4 / 8 ILE A 336
ARG A 335
VAL A 329
ASP A 406
 None
 1.04A 5vlmF-5bukA:
undetectable		 5vlmF-5bukA:
20.67