SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bul'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 5bul FLAVIN-DEPENDENT
HALOGENASE TRIPLE
MUTANT
(Streptomyces) 		5 / 12 SER A 212
VAL A 226
GLY A 225
GLY A 247
PHE A 259
 None
 1.12A 1fduA-5bulA:
5.0		 1fduA-5bulA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR6_A_DM2A2002_1
(ACRB)		 5bul FLAVIN-DEPENDENT
HALOGENASE TRIPLE
MUTANT
(Streptomyces) 		5 / 9 SER A 338
GLN A 342
SER A 302
GLY A  15
PHE A 295
 None
None
None
FAD  A 501 (-3.3A)
FAD  A 501 (-4.7A)
 1.31A 2dr6A-5bulA:
0.7		 2dr6A-5bulA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		 5bul FLAVIN-DEPENDENT
HALOGENASE TRIPLE
MUTANT
(Streptomyces) 		4 / 4 VAL A 124
TYR A 139
VAL A 148
SER A 150
 FAD  A 501 (-4.0A)
None
None
None
 1.39A 2x45B-5bulA:
undetectable		 2x45B-5bulA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 5bul FLAVIN-DEPENDENT
HALOGENASE TRIPLE
MUTANT
(Streptomyces) 		4 / 5 LYS A 207
SER A 212
LEU A  83
SER A  82
 None
 1.18A 3ijxH-5bulA:
undetectable		 3ijxH-5bulA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 5bul FLAVIN-DEPENDENT
HALOGENASE TRIPLE
MUTANT
(Streptomyces) 		4 / 6 GLY A  51
GLN A  55
ARG A  58
ILE A  92
 None
 1.12A 3kvvD-5bulA:
undetectable		 3kvvD-5bulA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 5bul FLAVIN-DEPENDENT
HALOGENASE TRIPLE
MUTANT
(Streptomyces) 		4 / 6 GLY A  51
GLN A  55
ARG A  58
ILE A  92
 None
 1.14A 3kvvF-5bulA:
undetectable		 3kvvF-5bulA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5bul FLAVIN-DEPENDENT
HALOGENASE TRIPLE
MUTANT
(Streptomyces) 		5 / 12 LEU A 153
ILE A  11
GLY A  13
ALA A 156
SER A 157
 None
None
FAD  A 501 (-3.2A)
None
FAD  A 501 (-4.7A)
 1.09A 3n8xB-5bulA:
1.2		 3n8xB-5bulA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5bul FLAVIN-DEPENDENT
HALOGENASE TRIPLE
MUTANT
(Streptomyces) 		5 / 12 ALA A 156
MET A 308
GLY A 311
ALA A  53
PRO A  16
 None
None
None
None
FAD  A 501 (-3.3A)
 1.25A 3tm4A-5bulA:
4.3		 3tm4A-5bulA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5bul FLAVIN-DEPENDENT
HALOGENASE TRIPLE
MUTANT
(Streptomyces) 		5 / 12 ALA A 156
MET A 308
GLY A 311
ALA A  53
PRO A  16
 None
None
None
None
FAD  A 501 (-3.3A)
 1.25A 3tm4B-5bulA:
4.1		 3tm4B-5bulA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 5bul FLAVIN-DEPENDENT
HALOGENASE TRIPLE
MUTANT
(Streptomyces) 		4 / 5 GLY A 360
PRO A 356
ASN A  86
TYR A 205
 None
 1.12A 3u8qA-5bulA:
undetectable		 3u8qA-5bulA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5bul FLAVIN-DEPENDENT
HALOGENASE TRIPLE
MUTANT
(Streptomyces) 		5 / 12 PHE A 104
LEU A  60
ILE A  57
ILE A 108
GLY A 378
 None
 1.06A 4enhA-5bulA:
undetectable		 4enhA-5bulA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 5bul FLAVIN-DEPENDENT
HALOGENASE TRIPLE
MUTANT
(Streptomyces) 		5 / 12 ALA A 314
GLY A  22
GLY A  18
ALA A 315
GLU A 118
 None
 0.93A 4lg1A-5bulA:
undetectable		 4lg1A-5bulA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 5bul FLAVIN-DEPENDENT
HALOGENASE TRIPLE
MUTANT
(Streptomyces) 		5 / 12 ALA A 314
GLY A  22
GLY A  18
ALA A 315
GLU A 118
 None
 0.94A 4lg1B-5bulA:
undetectable		 4lg1B-5bulA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5bul FLAVIN-DEPENDENT
HALOGENASE TRIPLE
MUTANT
(Streptomyces) 		4 / 7 VAL A 168
ILE A  12
ALA A 137
ILE A  11
 None
FAD  A 501 (-4.9A)
None
None
 0.66A 4uxqA-5bulA:
undetectable		 4uxqA-5bulA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5bul FLAVIN-DEPENDENT
HALOGENASE TRIPLE
MUTANT
(Streptomyces) 		4 / 5 SER A 305
ALA A  53
GLN A  98
THR A  96
 None
 1.19A 5n0wB-5bulA:
undetectable		 5n0wB-5bulA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5bul FLAVIN-DEPENDENT
HALOGENASE TRIPLE
MUTANT
(Streptomyces) 		3 / 3 SER A 305
ALA A  53
THR A  96
 None
 0.68A 5n0xB-5bulA:
undetectable		 5n0xB-5bulA:
23.68