SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bv3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 5bv3 M7GPPPX
DIPHOSPHATASE
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 115
ALA A 119
LEU A  33
LEU A  21
SER A  31
 None
 1.21A 1ictA-5bv3A:
undetectable
1ictC-5bv3A:
undetectable		 1ictA-5bv3A:
16.57
1ictC-5bv3A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_B_BEZB1352_0
(D-AMINO ACID OXIDASE)		 5bv3 M7GPPPX
DIPHOSPHATASE
(Saccharomyces
cerevisiae) 		4 / 4 TYR A 260
TYR A 313
ILE A 315
ARG A 220
 None
 1.46A 1ve9B-5bv3A:
2.2		 1ve9B-5bv3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5bv3 M7GPPPX
DIPHOSPHATASE
(Saccharomyces
cerevisiae) 		5 / 11 ARG A 144
MET A 141
GLU A 140
ILE A 315
ARG A 336
 None
 1.35A 1vhwA-5bv3A:
undetectable
1vhwD-5bv3A:
undetectable		 1vhwA-5bv3A:
21.11
1vhwD-5bv3A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5bv3 M7GPPPX
DIPHOSPHATASE
(Saccharomyces
cerevisiae) 		5 / 11 ARG A 144
MET A 141
GLU A 140
ILE A 315
ARG A 336
 None
 1.34A 1vhwC-5bv3A:
undetectable
1vhwE-5bv3A:
undetectable		 1vhwC-5bv3A:
21.11
1vhwE-5bv3A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5bv3 M7GPPPX
DIPHOSPHATASE
(Saccharomyces
cerevisiae) 		5 / 11 ARG A 336
ARG A 144
MET A 141
GLU A 140
ILE A 315
 None
 1.34A 1vhwA-5bv3A:
undetectable
1vhwD-5bv3A:
undetectable		 1vhwA-5bv3A:
21.11
1vhwD-5bv3A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5bv3 M7GPPPX
DIPHOSPHATASE
(Saccharomyces
cerevisiae) 		5 / 11 ARG A 336
ARG A 144
MET A 141
GLU A 140
ILE A 315
 None
 1.35A 1vhwC-5bv3A:
undetectable
1vhwE-5bv3A:
undetectable		 1vhwC-5bv3A:
21.11
1vhwE-5bv3A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 5bv3 M7GPPPX
DIPHOSPHATASE
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 233
PRO A 262
ILE A 294
LEU A 291
 None
M7G  A 401 (-4.6A)
None
None
 1.12A 1ya4B-5bv3A:
undetectable		 1ya4B-5bv3A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5bv3 M7GPPPX
DIPHOSPHATASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 158
HIS A 123
TYR A 264
 None
None
M7G  A 401 (-4.7A)
 1.14A 4fu8A-5bv3A:
undetectable		 4fu8A-5bv3A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5bv3 M7GPPPX
DIPHOSPHATASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 158
HIS A 123
TYR A 264
 None
None
M7G  A 401 (-4.7A)
 1.14A 4fu9A-5bv3A:
undetectable		 4fu9A-5bv3A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 5bv3 M7GPPPX
DIPHOSPHATASE
(Saccharomyces
cerevisiae) 		4 / 6 GLU A 329
ARG A 336
ARG A 144
GLU A 140
 None
 1.33A 4kr3A-5bv3A:
undetectable		 4kr3A-5bv3A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5bv3 M7GPPPX
DIPHOSPHATASE
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 329
GLU A 137
TYR A 142
ARG A 220
 None
 1.02A 4mi4B-5bv3A:
1.5
4mi4C-5bv3A:
undetectable		 4mi4B-5bv3A:
21.65
4mi4C-5bv3A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5bv3 M7GPPPX
DIPHOSPHATASE
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 329
GLU A 137
TYR A 142
ARG A 220
 None
 1.04A 4mj8B-5bv3A:
undetectable
4mj8C-5bv3A:
undetectable		 4mj8B-5bv3A:
21.43
4mj8C-5bv3A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 5bv3 M7GPPPX
DIPHOSPHATASE
(Saccharomyces
cerevisiae) 		4 / 4 ILE A 295
ASN A 234
ILE A 269
VAL A 258
 None
 1.17A 4uy87-5bv3A:
undetectable		 4uy87-5bv3A:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 5bv3 M7GPPPX
DIPHOSPHATASE
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 330
ILE A 315
HIS A 133
VAL A 135
 None
 1.20A 4xyzA-5bv3A:
1.4		 4xyzA-5bv3A:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5bv3 M7GPPPX
DIPHOSPHATASE
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 217
ASP A 221
ARG A 213
 None
 0.73A 5jwaA-5bv3A:
undetectable
5jwaH-5bv3A:
undetectable		 5jwaA-5bv3A:
19.89
5jwaH-5bv3A:
19.89