SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bv8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 5bv8 VON WILLEBRAND
FACTOR
(Homo
sapiens) 		5 / 12 PHE A1299
ILE A1453
ILE A1412
THR A1364
ALA A1317
 None
 1.12A 2j0dA-5bv8A:
undetectable		 2j0dA-5bv8A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 5bv8 VON WILLEBRAND
FACTOR
(Homo
sapiens) 		4 / 7 ILE A1309
ARG A1374
ARG A1379
PHE A1280
 None
 1.12A 2q6hA-5bv8A:
undetectable		 2q6hA-5bv8A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5bv8 VON WILLEBRAND
FACTOR
(Homo
sapiens) 		4 / 7 LEU A1361
VAL A1454
ILE A1380
ARG A1341
 None
 1.32A 3ik3A-5bv8A:
undetectable		 3ik3A-5bv8A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA279_0
(UNIVERSAL STRESS
PROTEIN)		 5bv8 VON WILLEBRAND
FACTOR
(Homo
sapiens) 		4 / 4 SER A1394
SER A1356
THR A1357
SER A1358
 None
 1.35A 3loqA-5bv8A:
1.4		 3loqA-5bv8A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 5bv8 VON WILLEBRAND
FACTOR
(Homo
sapiens) 		5 / 12 VAL A1439
LEU A1440
SER A1441
ALA A1420
LEU A1422
 None
 0.98A 4coxC-5bv8A:
undetectable		 4coxC-5bv8A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5bv8 VON WILLEBRAND
FACTOR
(Homo
sapiens) 		5 / 9 VAL A1439
LEU A1440
SER A1441
ALA A1420
LEU A1422
 None
 1.07A 4rs0A-5bv8A:
undetectable		 4rs0A-5bv8A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGZ_B_H4BB760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 5bv8 VON WILLEBRAND
FACTOR
(Homo
sapiens) 		4 / 7 PHE A1299
GLU A1305
MET A1304
VAL A1454
 None
 1.36A 4ugzA-5bv8A:
undetectable
4ugzB-5bv8A:
undetectable		 4ugzA-5bv8A:
21.50
4ugzB-5bv8A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADA_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5bv8 VON WILLEBRAND
FACTOR
(Homo
sapiens) 		4 / 7 PHE A1299
GLU A1305
MET A1304
VAL A1454
 None
 1.38A 5adaA-5bv8A:
undetectable
5adaB-5bv8A:
undetectable		 5adaA-5bv8A:
21.50
5adaB-5bv8A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 5bv8 VON WILLEBRAND
FACTOR
(Homo
sapiens) 		5 / 12 LEU A1282
LEU A1384
ALA A1386
SER A1442
LEU A1440
 None
 0.95A 5mwyA-5bv8A:
undetectable		 5mwyA-5bv8A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5bv8 VON WILLEBRAND
FACTOR
(Homo
sapiens) 		4 / 7 PHE A1299
GLU A1305
MET A1304
VAL A1454
 None
 1.37A 5unwA-5bv8A:
undetectable
5unwB-5bv8A:
undetectable		 5unwA-5bv8A:
21.50
5unwB-5bv8A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUI_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5bv8 VON WILLEBRAND
FACTOR
(Homo
sapiens) 		4 / 7 PHE A1299
GLU A1305
MET A1304
VAL A1454
 None
 1.30A 5vuiA-5bv8A:
undetectable
5vuiB-5bv8A:
undetectable		 5vuiA-5bv8A:
21.50
5vuiB-5bv8A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 5bv8 VON WILLEBRAND
FACTOR
(Homo
sapiens) 		5 / 12 PHE A1438
GLU A1452
LEU A1440
PHE A1299
LEU A1384
 None
 1.13A 5w7pA-5bv8A:
undetectable		 5w7pA-5bv8A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUT_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5bv8 VON WILLEBRAND
FACTOR
(Homo
sapiens) 		4 / 7 MET A1304
VAL A1454
PHE A1299
GLU A1305
 None
 1.35A 6autA-5bv8A:
undetectable
6autB-5bv8A:
undetectable		 6autA-5bv8A:
16.33
6autB-5bv8A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIC_A_H4BA802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5bv8 VON WILLEBRAND
FACTOR
(Homo
sapiens) 		4 / 7 MET A1304
VAL A1454
PHE A1299
GLU A1305
 None
 1.40A 6cicA-5bv8A:
undetectable
6cicB-5bv8A:
undetectable		 6cicA-5bv8A:
15.96
6cicB-5bv8A:
15.96