SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bvi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 5bvi INTERFERON
REGULATORY FACTOR 4
(Mus
musculus) 		4 / 7 VAL A 316
VAL A 405
ARG A 352
CYH A 356
 None
 1.14A 1t46A-5bviA:
undetectable		 1t46A-5bviA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 5bvi INTERFERON
REGULATORY FACTOR 4
(Mus
musculus) 		3 / 3 ASP A 337
GLU A 367
ARG A 411
 None
 0.87A 1wopA-5bviA:
undetectable		 1wopA-5bviA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5bvi INTERFERON
REGULATORY FACTOR 4
(Mus
musculus) 		3 / 3 SER A 285
ASP A 283
ASP A 288
 CL  A 503 (-4.7A)
None
None
 0.94A 3iv6C-5bviA:
undetectable		 3iv6C-5bviA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_H_RFPH1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5bvi INTERFERON
REGULATORY FACTOR 4
(Mus
musculus) 		5 / 12 ASP A 353
ARG A 328
LEU A 385
ILE A 334
ARG A 352
 None
 1.34A 4kmuH-5bviA:
undetectable		 4kmuH-5bviA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 5bvi INTERFERON
REGULATORY FACTOR 4
(Mus
musculus) 		4 / 6 PRO A 339
PRO A 407
LEU A 409
LEU A 252
 None
 1.17A 5tl8A-5bviA:
undetectable		 5tl8A-5bviA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 5bvi INTERFERON
REGULATORY FACTOR 4
(Mus
musculus) 		5 / 12 HIS A 404
GLY A 338
ALA A 341
ILE A 334
LEU A 385
 None
 1.15A 6b3bA-5bviA:
undetectable		 6b3bA-5bviA:
14.72