SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bvr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 5bvr ALPHA-ACTININ-LIKE
PROTEIN 1
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A  37
LEU A  99
ILE A 102
THR A  13
PHE A  18
 None
 0.99A 2bdmA-5bvrA:
0.9		 2bdmA-5bvrA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6U_A_BEZA501_0
(NIKD PROTEIN)		 5bvr ALPHA-ACTININ-LIKE
PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 7 HIS A 166
ARG A 167
PHE A 229
TYR A 225
 ZN  A 301 (-3.0A)
None
None
None
 1.41A 2q6uA-5bvrA:
undetectable		 2q6uA-5bvrA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 5bvr ALPHA-ACTININ-LIKE
PROTEIN 1
(Schizosaccharomy
ces
pombe) 		5 / 9 THR A 108
GLY A 104
LEU A 105
LEU A 101
ILE A  89
 None
 1.42A 3nbqA-5bvrA:
undetectable		 3nbqA-5bvrA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5bvr ALPHA-ACTININ-LIKE
PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 5 LEU A  27
PRO A  28
LEU A  22
ILE A  49
 None
 0.93A 4klrA-5bvrA:
undetectable		 4klrA-5bvrA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 5bvr ALPHA-ACTININ-LIKE
PROTEIN 1
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG A  25
GLN A  45
GLU A  48
 None
 0.75A 4tvtA-5bvrA:
undetectable		 4tvtA-5bvrA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5bvr ALPHA-ACTININ-LIKE
PROTEIN 1
(Schizosaccharomy
ces
pombe) 		5 / 12 MET A  84
LEU A  76
LEU A  43
ILE A  50
GLY A  51
 None
 1.10A 5gtrA-5bvrA:
undetectable		 5gtrA-5bvrA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 5bvr ALPHA-ACTININ-LIKE
PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 7 ILE A 110
PHE A  14
ASP A 214
SER A   8
 None
None
ZN  A 303 (-2.9A)
None
 1.33A 5nr3A-5bvrA:
undetectable		 5nr3A-5bvrA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5bvr ALPHA-ACTININ-LIKE
PROTEIN 1
(Schizosaccharomy
ces
pombe) 		3 / 3 CYH A 208
MET A 185
ASN A 184
 None
 1.38A 5qh8A-5bvrA:
undetectable		 5qh8A-5bvrA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5bvr ALPHA-ACTININ-LIKE
PROTEIN 1
(Schizosaccharomy
ces
pombe) 		3 / 3 TYR A 173
ASN A 184
LEU A 157
 None
 0.81A 6b58A-5bvrA:
undetectable		 6b58A-5bvrA:
19.51