SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bw4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Catenulispora
acidiphila) 		5 / 12 LEU A 164
GLY A 123
GLY A 119
LEU A 116
GLY A 114
 None
None
None
SAM  A 301 (-4.0A)
SAM  A 301 ( 4.6A)
 1.20A 1y4lA-5bw4A:
undetectable		 1y4lA-5bw4A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Catenulispora
acidiphila) 		5 / 12 PRO A 166
VAL A 185
ILE A 143
VAL A 169
LEU A 178
 None
 1.07A 1z9hA-5bw4A:
undetectable		 1z9hA-5bw4A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Catenulispora
acidiphila) 		5 / 12 PRO A 166
VAL A 185
ILE A 143
VAL A 169
LEU A 178
 None
 1.08A 1z9hB-5bw4A:
undetectable		 1z9hB-5bw4A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Catenulispora
acidiphila) 		5 / 12 PRO A 166
VAL A 185
ILE A 143
VAL A 169
LEU A 178
 None
 1.07A 1z9hC-5bw4A:
undetectable		 1z9hC-5bw4A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Catenulispora
acidiphila) 		5 / 12 PRO A 166
VAL A 185
ILE A 143
VAL A 169
LEU A 178
 None
 1.07A 1z9hD-5bw4A:
undetectable		 1z9hD-5bw4A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Catenulispora
acidiphila) 		5 / 11 ILE A 143
SER A 144
ILE A 145
LEU A 164
VAL A 169
 None
 0.76A 2kawA-5bw4A:
undetectable		 2kawA-5bw4A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Catenulispora
acidiphila) 		5 / 9 GLY A 138
ALA A 139
ASP A 105
VAL A 107
GLY A 102
 None
 1.03A 3ektA-5bw4A:
undetectable		 3ektA-5bw4A:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Catenulispora
acidiphila) 		6 / 12 GLY A  38
GLY A  40
PRO A  62
ALA A  92
LEU A 110
LEU A 116
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-4.5A)
SAM  A 301 ( 4.3A)
SAM  A 301 (-4.7A)
SAM  A 301 (-4.0A)
 0.48A 3mteA-5bw4A:
26.9		 3mteA-5bw4A:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Catenulispora
acidiphila) 		6 / 12 GLY A  38
GLY A  40
PRO A  62
ALA A  92
LEU A 110
LEU A 116
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-4.5A)
SAM  A 301 ( 4.3A)
SAM  A 301 (-4.7A)
SAM  A 301 (-4.0A)
 0.46A 3p2kA-5bw4A:
25.5		 3p2kA-5bw4A:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Catenulispora
acidiphila) 		6 / 12 GLY A  38
GLY A  40
PRO A  62
GLU A  94
LEU A 110
LEU A 116
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.2A)
SAM  A 301 (-4.7A)
SAM  A 301 (-4.0A)
 0.45A 3p2kB-5bw4A:
25.4		 3p2kB-5bw4A:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Catenulispora
acidiphila) 		6 / 12 GLY A  38
GLY A  40
PRO A  62
ALA A  92
LEU A 110
LEU A 116
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-4.5A)
SAM  A 301 ( 4.3A)
SAM  A 301 (-4.7A)
SAM  A 301 (-4.0A)
 0.44A 3p2kC-5bw4A:
25.5		 3p2kC-5bw4A:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Catenulispora
acidiphila) 		6 / 12 GLY A  38
GLY A  40
PRO A  62
ALA A  92
LEU A 110
LEU A 116
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-4.5A)
SAM  A 301 ( 4.3A)
SAM  A 301 (-4.7A)
SAM  A 301 (-4.0A)
 0.42A 3p2kD-5bw4A:
24.3		 3p2kD-5bw4A:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Catenulispora
acidiphila) 		5 / 12 TRP A  23
ILE A  33
ALA A 104
VAL A  96
LEU A   7
 None
 1.25A 3s79A-5bw4A:
undetectable		 3s79A-5bw4A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Catenulispora
acidiphila) 		4 / 5 ASN A  85
ALA A  49
TYR A  46
ALA A  74
 None
 1.26A 3twpD-5bw4A:
3.3		 3twpD-5bw4A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Catenulispora
acidiphila) 		5 / 12 LEU A 117
LEU A 128
ARG A 118
ILE A 158
THR A 175
 None
 1.24A 4f4dB-5bw4A:
2.2		 4f4dB-5bw4A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Catenulispora
acidiphila) 		4 / 5 PRO A  62
ASP A  61
ILE A  93
VAL A  35
 SAM  A 301 (-4.5A)
SAM  A 301 (-2.8A)
SAM  A 301 (-4.3A)
None
 1.37A 4hytA-5bw4A:
2.1		 4hytA-5bw4A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ8_A_ASDA602_1
(CYTOCHROME P450 19A1)		 5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Catenulispora
acidiphila) 		5 / 10 TRP A  23
ILE A  33
ALA A 104
VAL A  96
LEU A   7
 None
 1.30A 4kq8A-5bw4A:
undetectable		 4kq8A-5bw4A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Catenulispora
acidiphila) 		5 / 12 VAL A 109
LEU A 116
VAL A 127
GLY A 130
LEU A 141
 None
SAM  A 301 (-4.0A)
None
None
None
 1.09A 4rrwB-5bw4A:
undetectable		 4rrwB-5bw4A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Catenulispora
acidiphila) 		5 / 12 VAL A 109
LEU A 116
VAL A 127
GLY A 130
LEU A 141
 None
SAM  A 301 (-4.0A)
None
None
None
 1.09A 4rrzB-5bw4A:
undetectable		 4rrzB-5bw4A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Catenulispora
acidiphila) 		5 / 11 THR A  70
ALA A  51
ASP A  36
THR A  39
GLY A  59
 None
None
SAM  A 301 ( 4.7A)
None
None
 1.32A 4zjoD-5bw4A:
undetectable		 4zjoD-5bw4A:
13.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Catenulispora
acidiphila) 		12 / 12 GLY A  38
GLY A  40
THR A  44
ASP A  61
PRO A  62
ARG A  66
ILE A  93
GLU A  94
LEU A 110
TRP A 113
LYS A 115
LEU A 116
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.3A)
SAM  A 301 (-2.8A)
SAM  A 301 (-4.5A)
SAM  A 301 (-2.9A)
SAM  A 301 (-4.3A)
SAM  A 301 (-3.2A)
SAM  A 301 (-4.7A)
SAM  A 301 (-3.7A)
None
SAM  A 301 (-4.0A)
 0.00A 5bw4A-5bw4A:
22.0		 5bw4A-5bw4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Catenulispora
acidiphila) 		9 / 12 GLY A  38
GLY A  40
PRO A  62
ALA A  63
ALA A  92
ILE A  93
LEU A 110
LYS A 115
LEU A 116
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-4.5A)
SAM  A 301 ( 4.0A)
SAM  A 301 ( 4.3A)
SAM  A 301 (-4.3A)
SAM  A 301 (-4.7A)
None
SAM  A 301 (-4.0A)
 0.50A 5bw4B-5bw4A:
34.6		 5bw4B-5bw4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Catenulispora
acidiphila) 		5 / 12 GLY A  38
GLY A  40
LEU A 110
GLU A  94
LEU A 116
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-4.7A)
SAM  A 301 (-3.2A)
SAM  A 301 (-4.0A)
 1.04A 5c0oE-5bw4A:
12.4		 5c0oE-5bw4A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Catenulispora
acidiphila) 		5 / 11 THR A  70
ALA A  71
GLY A  81
GLY A  82
ALA A  83
 None
 0.99A 5lf3K-5bw4A:
undetectable
5lf3L-5bw4A:
undetectable		 5lf3K-5bw4A:
20.70
5lf3L-5bw4A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Catenulispora
acidiphila) 		5 / 11 THR A  70
ALA A  71
GLY A  81
GLY A  82
ALA A  83
 None
 0.99A 5lf3Y-5bw4A:
undetectable
5lf3Z-5bw4A:
undetectable		 5lf3Y-5bw4A:
20.70
5lf3Z-5bw4A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Catenulispora
acidiphila) 		5 / 11 THR A  70
ALA A  71
GLY A  81
GLY A  82
ALA A  83
 None
 0.94A 5lf7K-5bw4A:
undetectable
5lf7L-5bw4A:
undetectable		 5lf7K-5bw4A:
20.70
5lf7L-5bw4A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Catenulispora
acidiphila) 		5 / 11 THR A  70
ALA A  71
GLY A  81
GLY A  82
ALA A  83
 None
 0.95A 5lf7Y-5bw4A:
undetectable
5lf7Z-5bw4A:
undetectable		 5lf7Y-5bw4A:
20.70
5lf7Z-5bw4A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Catenulispora
acidiphila) 		3 / 3 ARG A 177
GLY A 123
GLU A 124
 None
 0.53A 6fgdA-5bw4A:
2.7		 6fgdA-5bw4A:
21.31