SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bwa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 5bwa ORNITHINE
DECARBOXYLASE
(Homo
sapiens) 		5 / 11 LEU A 340
ILE A 355
LYS A 352
VAL A 288
PHE A 383
 None
 1.32A 1gx9A-5bwaA:
undetectable		 1gx9A-5bwaA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 5bwa ORNITHINE
DECARBOXYLASE
(Homo
sapiens) 		3 / 3 ASN A 319
PHE A 326
VAL A 288
 None
 0.61A 1kijA-5bwaA:
undetectable		 1kijA-5bwaA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 5bwa ORNITHINE
DECARBOXYLASE
(Homo
sapiens) 		5 / 12 PRO A 113
THR A 132
ILE A 234
GLY A 235
ALA A  67
 PLP  A 600 ( 4.9A)
None
None
None
PLP  A 600 ( 3.8A)
 0.91A 1nv8A-5bwaA:
undetectable		 1nv8A-5bwaA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 5bwa ORNITHINE
DECARBOXYLASE
(Homo
sapiens) 		5 / 12 PRO A 113
THR A 132
ILE A 234
GLY A 235
ALA A  67
 PLP  A 600 ( 4.9A)
None
None
None
PLP  A 600 ( 3.8A)
 0.93A 1sg9B-5bwaA:
undetectable		 1sg9B-5bwaA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 5bwa ORNITHINE
DECARBOXYLASE
ORNITHINE
DECARBOXYLASE
ANTIZYME 1
(Homo
sapiens) 		4 / 4 VAL B 158
ASP A 134
LEU A 151
ARG B 100
 None
 1.40A 2ziaA-5bwaB:
undetectable		 2ziaA-5bwaB:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_F_RTLF178_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5bwa ORNITHINE
DECARBOXYLASE
(Homo
sapiens) 		5 / 11 LEU A  49
ALA A 283
PHE A 284
ALA A  43
MET A 409
 None
 1.19A 3bszF-5bwaA:
undetectable		 3bszF-5bwaA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 5bwa ORNITHINE
DECARBOXYLASE
ORNITHINE
DECARBOXYLASE
ANTIZYME 1
(Homo
sapiens) 		5 / 12 SER B 191
PHE B 195
ILE B 174
PHE B 192
ASP A 332
 None
None
None
PLP  A 600 ( 4.4A)
None
 1.42A 3ko0G-5bwaB:
undetectable
3ko0H-5bwaB:
undetectable
3ko0I-5bwaB:
undetectable
3ko0J-5bwaB:
undetectable		 3ko0G-5bwaB:
21.47
3ko0H-5bwaB:
21.47
3ko0I-5bwaB:
21.47
3ko0J-5bwaB:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 5bwa ORNITHINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 5 GLY A 321
VAL A 322
ASP A 364
THR A 359
 None
 1.12A 3vqrB-5bwaA:
undetectable		 3vqrB-5bwaA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5bwa ORNITHINE
DECARBOXYLASE
ANTIZYME 1
(Homo
sapiens) 		4 / 8 ARG B 131
ASN B 117
GLU B 105
ASP B 111
 None
 1.11A 4d39A-5bwaB:
undetectable		 4d39A-5bwaB:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 5bwa ORNITHINE
DECARBOXYLASE
(Homo
sapiens) 		5 / 11 ALA A  39
GLY A 357
GLY A 321
ASP A 364
ASN A 319
 None
 1.12A 4dcmA-5bwaA:
undetectable		 4dcmA-5bwaA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_D_RAPD201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 5bwa ORNITHINE
DECARBOXYLASE
(Homo
sapiens) 		5 / 12 ASP A 260
VAL A 209
ILE A 212
PRO A  60
ILE A 271
 None
 1.20A 4drhD-5bwaA:
undetectable		 4drhD-5bwaA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5bwa ORNITHINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 8 GLN A 341
ILE A  28
GLY A 378
ASN A 319
 None
 0.97A 4fgjA-5bwaA:
undetectable
4fgjB-5bwaA:
undetectable		 4fgjA-5bwaA:
19.87
4fgjB-5bwaA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 5bwa ORNITHINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 4 VAL A 254
THR A 252
GLU A 250
GLU A 249
 None
 1.21A 4l78A-5bwaA:
undetectable		 4l78A-5bwaA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_ACTC202_0
(RETINOL-BINDING
PROTEIN 2)		 5bwa ORNITHINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 6 TYR A 230
GLU A 106
GLN A 129
LEU A 231
 None
 1.28A 4qzuC-5bwaA:
undetectable		 4qzuC-5bwaA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 5bwa ORNITHINE
DECARBOXYLASE
(Homo
sapiens) 		5 / 12 VAL A 192
THR A  63
PHE A  65
ILE A 109
GLN A 129
 None
 1.29A 5hgcA-5bwaA:
undetectable		 5hgcA-5bwaA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5bwa ORNITHINE
DECARBOXYLASE
(Homo
sapiens) 		5 / 12 ILE A 155
VAL A 152
VAL A 191
SER A 195
ALA A 211
 None
 1.11A 5n0sB-5bwaA:
undetectable		 5n0sB-5bwaA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGJ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5bwa ORNITHINE
DECARBOXYLASE
ANTIZYME 1
(Homo
sapiens) 		3 / 3 VAL B 118
VAL B 103
GLN B 166
 None
 0.64A 5qgjA-5bwaB:
undetectable		 5qgjA-5bwaB:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA304_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5bwa ORNITHINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 4 ARG A 270
THR A  63
GLY A  86
PHE A  65
 None
 1.33A 5uunA-5bwaA:
undetectable		 5uunA-5bwaA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5bwa ORNITHINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 7 ILE A 108
GLN A  99
VAL A 103
ALA A  81
 None
 0.84A 6cduC-5bwaA:
undetectable
6cduD-5bwaA:
undetectable		 6cduC-5bwaA:
18.67
6cduD-5bwaA:
18.67