SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bwi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 10 ALA A 353
GLY A 357
LEU A 335
LEU A  19
PRO A  20
 None
 1.39A 1cmcA-5bwiA:
undetectable
1cmcB-5bwiA:
undetectable		 1cmcA-5bwiA:
10.23
1cmcB-5bwiA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 9 LEU A 335
ILE A  26
LEU A 237
VAL A 292
GLY A 291
 None
 1.19A 1e7aB-5bwiA:
undetectable		 1e7aB-5bwiA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 11 ARG A  95
ILE A  88
ALA A  92
LEU A  96
ALA A  97
 None
 1.30A 1jb0B-5bwiA:
undetectable		 1jb0B-5bwiA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		4 / 5 TYR A 321
TYR A 322
ILE A 405
GLY A 414
 None
 1.07A 1kifA-5bwiA:
undetectable		 1kifA-5bwiA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		4 / 5 TYR A 321
TYR A 322
ILE A 405
GLY A 414
 None
 1.07A 1kifB-5bwiA:
undetectable		 1kifB-5bwiA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		4 / 5 TYR A 321
TYR A 322
ILE A 405
GLY A 414
 None
 1.07A 1kifC-5bwiA:
undetectable		 1kifC-5bwiA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		4 / 5 TYR A 321
TYR A 322
ILE A 405
GLY A 414
 None
 1.07A 1kifD-5bwiA:
undetectable		 1kifD-5bwiA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		4 / 5 TYR A 321
TYR A 322
ILE A 405
GLY A 414
 None
 1.07A 1kifE-5bwiA:
undetectable		 1kifE-5bwiA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		4 / 5 TYR A 321
TYR A 322
ILE A 405
GLY A 414
 None
 1.07A 1kifF-5bwiA:
undetectable		 1kifF-5bwiA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		4 / 5 TYR A 321
TYR A 322
ILE A 405
GLY A 414
 None
 1.07A 1kifG-5bwiA:
undetectable		 1kifG-5bwiA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		4 / 5 TYR A 321
TYR A 322
ILE A 405
GLY A 414
 None
 1.07A 1kifH-5bwiA:
undetectable		 1kifH-5bwiA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_2
(PROTEASE RETROPEPSIN)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 11 ALA A 330
ASP A 444
ILE A 324
VAL A 364
ILE A 362
 None
 0.85A 1t3rB-5bwiA:
undetectable		 1t3rB-5bwiA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		4 / 7 LEU A 210
GLY A 185
VAL A 164
ASP A 202
 None
 0.95A 1t88A-5bwiA:
undetectable		 1t88A-5bwiA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 10 GLY A 291
PHE A 327
VAL A 292
GLY A  32
VAL A 284
 None
 1.16A 1v3qE-5bwiA:
undetectable		 1v3qE-5bwiA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		4 / 5 TYR A 321
TYR A 322
ILE A 405
GLY A 414
 None
 1.00A 1ve9A-5bwiA:
undetectable		 1ve9A-5bwiA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		4 / 6 VAL A 292
LEU A 253
PHE A 251
MET A 236
 None
 1.17A 1x8vA-5bwiA:
undetectable		 1x8vA-5bwiA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		4 / 5 LEU A 275
GLY A 266
PRO A 319
ALA A 274
 None
 0.90A 2aohA-5bwiA:
undetectable		 2aohA-5bwiA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 11 ILE A  66
GLU A 124
GLY A 142
GLY A  67
GLU A 140
 None
 1.25A 2fn1A-5bwiA:
undetectable		 2fn1A-5bwiA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 11 ILE A  66
GLU A 124
GLY A 142
GLY A  67
GLU A 140
 None
 1.22A 2fn1B-5bwiA:
undetectable		 2fn1B-5bwiA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		4 / 4 LEU A 347
THR A 346
ILE A 362
HIS A 350
 None
 1.22A 2jfaB-5bwiA:
undetectable		 2jfaB-5bwiA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 12 ASN A 279
LEU A 281
LEU A 392
THR A 366
PHE A 348
 None
 1.22A 2oaxA-5bwiA:
undetectable		 2oaxA-5bwiA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 12 ASN A 279
LEU A 281
LEU A 392
THR A 366
PHE A 348
 None
 1.34A 2oaxB-5bwiA:
undetectable		 2oaxB-5bwiA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 12 ASN A 279
LEU A 281
LEU A 392
THR A 366
PHE A 348
 None
 1.31A 2oaxF-5bwiA:
undetectable		 2oaxF-5bwiA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		4 / 8 PRO A 382
VAL A 381
SER A 380
ALA A 353
 None
 1.11A 2v41G-5bwiA:
undetectable
2v41H-5bwiA:
undetectable		 2v41G-5bwiA:
19.18
2v41H-5bwiA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		4 / 7 TYR A 192
GLY A 242
ALA A 243
LEU A 210
 None
 0.64A 2wekB-5bwiA:
undetectable		 2wekB-5bwiA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 9 ALA A 330
ASP A 444
ILE A 324
VAL A 364
ILE A 362
 None
 0.93A 3ekvB-5bwiA:
undetectable		 3ekvB-5bwiA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 11 ALA A  27
GLY A  32
ILE A  26
SER A 290
VAL A 292
 GOL  A 501 ( 3.7A)
None
None
None
None
 1.22A 3gyqB-5bwiA:
undetectable		 3gyqB-5bwiA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_1
(GAG-POL POLYPROTEIN)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 12 ALA A 330
ASP A 444
ILE A 324
VAL A 364
ILE A 362
 None
 0.83A 3jvyA-5bwiA:
undetectable		 3jvyA-5bwiA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		4 / 7 ASP A 230
GLN A 212
PRO A 235
GLN A 238
 None
 1.16A 3l2vA-5bwiA:
undetectable		 3l2vA-5bwiA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		3 / 3 TRP A 167
ALA A 157
VAL A 164
 None
 0.85A 3l8lA-5bwiA:
undetectable
3l8lB-5bwiA:
undetectable		 3l8lA-5bwiA:
4.15
3l8lB-5bwiA:
2.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 12 GLY A 394
GLY A 393
ILE A 223
MET A 226
SER A 273
 None
 1.05A 3nk7A-5bwiA:
undetectable		 3nk7A-5bwiA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 11 GLY A 323
ALA A 274
ILE A 324
PHE A 280
ALA A  31
 None
 1.24A 3nmuB-5bwiA:
0.8
3nmuJ-5bwiA:
undetectable		 3nmuB-5bwiA:
20.41
3nmuJ-5bwiA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 9 ALA A 330
ASP A 444
ILE A 324
VAL A 364
ILE A 362
 None
 0.97A 3nu4A-5bwiA:
undetectable		 3nu4A-5bwiA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 10 ALA A 330
ASP A 444
ILE A 324
VAL A 364
ILE A 362
 None
 0.86A 3nu6A-5bwiA:
undetectable		 3nu6A-5bwiA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 10 ALA A 330
ASP A 444
ILE A 324
VAL A 364
ILE A 362
 None
 0.92A 3nujA-5bwiA:
undetectable		 3nujA-5bwiA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 9 ALA A 330
ASP A 444
ILE A 324
VAL A 364
ILE A 362
 None
 0.94A 3nuoA-5bwiA:
undetectable		 3nuoA-5bwiA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_1
(HIV-1 PROTEASE)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 11 ALA A 330
ASP A 444
ILE A 324
VAL A 364
ILE A 362
 None
 0.94A 3oy4A-5bwiA:
undetectable		 3oy4A-5bwiA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 11 ARG A  95
ILE A  88
ALA A  92
LEU A  96
ALA A  97
 None
 1.30A 3pcqB-5bwiA:
undetectable		 3pcqB-5bwiA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 9 ARG A  95
ALA A 128
GLY A 110
ILE A  66
THR A  89
 None
 1.34A 3spkA-5bwiA:
undetectable		 3spkA-5bwiA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 10 ALA A 330
ASP A 444
ILE A 324
VAL A 364
ILE A 362
 None
 1.07A 4dqcA-5bwiA:
undetectable		 4dqcA-5bwiA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		4 / 6 PHE A 327
ASN A 279
ALA A 283
LEU A 335
 None
 1.00A 4ejgD-5bwiA:
undetectable		 4ejgD-5bwiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_B_PQNB840_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 9 ARG A  95
ILE A  88
ALA A  92
LEU A  96
ALA A  97
 None
 1.33A 4fe1B-5bwiA:
undetectable		 4fe1B-5bwiA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		4 / 8 GLY A 287
PHE A  30
ILE A  26
PHE A 327
 None
 0.95A 4fglD-5bwiA:
undetectable		 4fglD-5bwiA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 12 HIS A 213
TYR A 215
ILE A  35
GLY A  67
GLY A 110
 None
 1.08A 4hfpB-5bwiA:
undetectable		 4hfpB-5bwiA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		4 / 7 PRO A 218
SER A 258
TRP A 260
SER A 268
 None
 1.15A 4k7gB-5bwiA:
undetectable		 4k7gB-5bwiA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 10 ALA A 330
ASP A 444
ILE A 324
VAL A 364
ILE A 362
 None
 0.90A 4q1wB-5bwiA:
undetectable		 4q1wB-5bwiA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 12 ALA A 330
ASP A 444
ILE A 324
VAL A 364
ILE A 362
 None
 0.91A 4q1yB-5bwiA:
undetectable		 4q1yB-5bwiA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		4 / 6 GLY A 288
PHE A  30
ILE A  26
PHE A 327
 None
 1.05A 4qogA-5bwiA:
undetectable
4qogB-5bwiA:
undetectable		 4qogA-5bwiA:
18.57
4qogB-5bwiA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 12 ILE A  26
GLY A 332
PHE A  30
ARG A 334
VAL A 352
 None
GOL  A 501 ( 4.9A)
None
None
None
 1.04A 4rvdA-5bwiA:
undetectable		 4rvdA-5bwiA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 12 ILE A  26
GLY A 332
PHE A  30
ARG A 334
VAL A 352
 None
GOL  A 501 ( 4.9A)
None
None
None
 1.02A 4rvgA-5bwiA:
undetectable		 4rvgA-5bwiA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 10 ARG A  95
ILE A  88
ALA A  92
LEU A  96
ALA A  97
 None
 1.35A 4xk8B-5bwiA:
undetectable		 4xk8B-5bwiA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 12 GLY A 297
TYR A  42
SER A  34
ALA A 304
GLU A 320
 None
GOL  A 502 (-4.6A)
None
None
None
 1.47A 4ymgA-5bwiA:
undetectable		 4ymgA-5bwiA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		4 / 5 GLU A 255
GLU A  36
ASN A  69
GLU A 144
 None
 1.47A 5dwkC-5bwiA:
undetectable		 5dwkC-5bwiA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 12 ASP A 377
ASP A 444
PHE A 445
GLY A 358
SER A 380
 None
 1.40A 5hfjH-5bwiA:
undetectable		 5hfjH-5bwiA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 9 ALA A 330
ASP A 444
ILE A 324
VAL A 364
ILE A 362
 None
 0.95A 5kr0A-5bwiA:
undetectable		 5kr0A-5bwiA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 10 ALA A 330
ASP A 444
ILE A 324
VAL A 364
ILE A 362
 None
 1.05A 5kr1A-5bwiA:
undetectable		 5kr1A-5bwiA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		3 / 3 THR A 196
THR A 256
LEU A 233
 None
 0.69A 5m66D-5bwiA:
undetectable		 5m66D-5bwiA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		4 / 6 GLY A  80
PRO A  81
THR A  89
SER A  41
 None
 1.10A 5ny7A-5bwiA:
2.9		 5ny7A-5bwiA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 12 ALA A  23
ARG A 334
VAL A 352
ASP A 355
GLY A 357
 None
 1.16A 5x24A-5bwiA:
undetectable		 5x24A-5bwiA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		4 / 5 LEU A 281
VAL A 277
GLU A 320
LEU A 294
 None
 1.03A 5xooB-5bwiA:
undetectable		 5xooB-5bwiA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_1
(PROTEASE)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 12 ALA A 330
ASP A 444
ILE A 324
VAL A 364
ILE A 362
 None
 0.83A 6dgxB-5bwiA:
undetectable		 6dgxB-5bwiA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_B_PQNB2002_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5bwi GLYCOSIDE HYDROLASE
FAMILY 79
(Burkholderia
pseudomallei) 		5 / 9 ARG A  95
ILE A  88
ALA A  92
LEU A  96
ALA A  97
 None
 1.42A 6hqbB-5bwiA:
undetectable		 6hqbB-5bwiA:
12.31