SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bx1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Z2B_C_VLBC800_2 (TUBULIN ALPHA CHAIN)	5bx1	PROTEIN TYROSINE PHOSPHATASE TYPE IVA 1 (Homo sapiens)	4 / 5	PRO A 112 VAL A 115 VAL A 12 ILE A 21	SO4 A 202 (-4.5A) None None None	0.97A	1z2bC-5bx1A: undetectable	1z2bC-5bx1A: 15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2G72_B_SAMB2002_0 (PHENYLETHANOLAMINE N-METHYLTRANSFERASE)	5bx1	PROTEIN TYROSINE PHOSPHATASE TYPE IVA 1 (Homo sapiens)	5 / 12	LEU A 87 ILE A 80 VAL A 48 ALA A 116 VAL A 102	None	1.07A	2g72B-5bx1A: undetectable	2g72B-5bx1A: 20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TI1_A_B49A299_1 (CYCLIN-DEPENDENT KINASE 2)	5bx1	PROTEIN TYROSINE PHOSPHATASE TYPE IVA 1 (Homo sapiens)	5 / 9	ILE A 120 ALA A 129 VAL A 12 PHE A 132 LYS A 89	None None None 4XA A 201 (-4.1A) None	1.33A	3ti1A-5bx1A: undetectable	3ti1A-5bx1A: 19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LV9_B_20JB602_1 (NICOTINAMIDE PHOSPHORIBOSYLTRANSF ERASE)	5bx1	PROTEIN TYROSINE PHOSPHATASE TYPE IVA 1 (Homo sapiens)	4 / 7	TYR A 40 ILE A 63 ILE A 45 ALA A 101	None	0.94A	4lv9B-5bx1A: undetectable	4lv9B-5bx1A: 18.33

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1Z2B_C_VLBC800_2","TUBULIN ALPHA CHAIN","5bx1","PROTEIN TYROSINE PHOSPHATASE TYPE IVA 1","Homo sapiens",4,"PRO A 112;VAL A 115;VAL A  12;ILE A  21","SO4 A 202 (-4.5A);None;None;None","0.97A","1z2bC-5bx1A:undetectable","1z2bC-5bx1A:15.62"],["2G72_B_SAMB2002_0","PHENYLETHANOLAMINE N-METHYLTRANSFERASE","5bx1","PROTEIN TYROSINE PHOSPHATASE TYPE IVA 1","Homo sapiens",5,"LEU A  87;ILE A  80;VAL A  48;ALA A 116;VAL A 102","None","1.07A","2g72B-5bx1A:undetectable","2g72B-5bx1A:20.22"],["3TI1_A_B49A299_1","CYCLIN-DEPENDENT KINASE 2","5bx1","PROTEIN TYROSINE PHOSPHATASE TYPE IVA 1","Homo sapiens",5,"ILE A 120;ALA A 129;VAL A  12;PHE A 132;LYS A  89","None;None;None;4XA A 201 (-4.1A);None","1.33A","3ti1A-5bx1A:undetectable","3ti1A-5bx1A:19.47"],["4LV9_B_20JB602_1","NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE","5bx1","PROTEIN TYROSINE PHOSPHATASE TYPE IVA 1","Homo sapiens",4,"TYR A  40;ILE A  63;ILE A  45;ALA A 101","None","0.94A","4lv9B-5bx1A:undetectable","4lv9B-5bx1A:18.33"]]