SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bxi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 5bxi NUCLEOSIDE
DIPHOSPHATE KINASE
(Toxoplasma
gondii) 		5 / 12 THR A   9
GLY A 121
SER A 122
VAL A  13
ILE A 118
 None
 0.96A 2b25B-5bxiA:
undetectable		 2b25B-5bxiA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 5bxi NUCLEOSIDE
DIPHOSPHATE KINASE
(Toxoplasma
gondii) 		3 / 3 TYR A  35
TYR A 153
GLU A   7
 None
 0.98A 3pfgA-5bxiA:
undetectable		 3pfgA-5bxiA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 5bxi NUCLEOSIDE
DIPHOSPHATE KINASE
(Toxoplasma
gondii) 		4 / 6 GLY A 108
ARG A  20
GLU A  25
ARG A  29
 None
 0.93A 4bqfA-5bxiA:
undetectable		 4bqfA-5bxiA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 5bxi NUCLEOSIDE
DIPHOSPHATE KINASE
(Toxoplasma
gondii) 		4 / 6 GLN A  32
VAL A 152
LEU A 106
ARG A  90
 None
None
None
BCT  A 201 ( 4.9A)
 1.17A 6brdB-5bxiA:
undetectable		 6brdB-5bxiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5bxi NUCLEOSIDE
DIPHOSPHATE KINASE
(Toxoplasma
gondii) 		4 / 6 VAL A  13
LEU A  93
LEU A 106
ARG A 107
 None
None
None
BCT  A 201 (-4.6A)
 0.72A 6e43A-5bxiA:
undetectable		 6e43A-5bxiA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5bxi NUCLEOSIDE
DIPHOSPHATE KINASE
(Toxoplasma
gondii) 		4 / 6 VAL A  13
LEU A  93
LEU A 106
ARG A 107
 None
None
None
BCT  A 201 (-4.6A)
 0.73A 6e43B-5bxiA:
undetectable		 6e43B-5bxiA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5bxi NUCLEOSIDE
DIPHOSPHATE KINASE
(Toxoplasma
gondii) 		4 / 6 VAL A  13
LEU A  93
LEU A 106
ARG A 107
 None
None
None
BCT  A 201 (-4.6A)
 0.75A 6e43C-5bxiA:
undetectable		 6e43C-5bxiA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5bxi NUCLEOSIDE
DIPHOSPHATE KINASE
(Toxoplasma
gondii) 		4 / 6 VAL A  13
LEU A  93
LEU A 106
ARG A 107
 None
None
None
BCT  A 201 (-4.6A)
 0.82A 6e43D-5bxiA:
undetectable		 6e43D-5bxiA:
17.28