SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bxo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 5bxo TANKYRASE-2
(Homo
sapiens) 		5 / 12 HIS A 571
ALA A 566
GLY A 535
ALA A 575
PRO A 595
 None
 1.12A 1mjqC-5bxoA:
undetectable
1mjqD-5bxoA:
undetectable		 1mjqC-5bxoA:
22.50
1mjqD-5bxoA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 5bxo TANKYRASE-2
(Homo
sapiens) 		5 / 12 HIS A 571
ALA A 566
GLY A 535
ALA A 575
PRO A 595
 None
 1.13A 1mjqI-5bxoA:
undetectable
1mjqJ-5bxoA:
undetectable		 1mjqI-5bxoA:
22.50
1mjqJ-5bxoA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 5bxo TANKYRASE-2
(Homo
sapiens) 		5 / 11 ILE A 607
LEU A 596
HIS A 614
LEU A 612
ALA A 616
 None
None
SO4  A 702 (-4.0A)
None
None
 1.10A 4p65E-5bxoA:
undetectable
4p65F-5bxoA:
undetectable
4p65J-5bxoA:
undetectable
4p65L-5bxoA:
undetectable		 4p65E-5bxoA:
13.86
4p65F-5bxoA:
10.98
4p65J-5bxoA:
10.98
4p65L-5bxoA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 5bxo TANKYRASE-2
(Homo
sapiens) 		3 / 3 ASP A 589
GLY A 558
ASP A 556
 None
 0.52A 4xdtA-5bxoA:
undetectable		 4xdtA-5bxoA:
19.35