SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bxp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		4 / 7 SER A 421
PRO A 466
SER A 468
ALA A 424
 LOG  A 702 ( 4.5A)
GAL  A 701 (-3.7A)
None
SO4  A 705 (-3.5A)
 0.99A 1k5qA-5bxpA:
undetectable
1k5qB-5bxpA:
undetectable		 1k5qA-5bxpA:
14.93
1k5qB-5bxpA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		4 / 7 GLU A 257
GLU A 216
TRP A 373
TRP A 465
 None
GAL  A 701 (-2.8A)
LOG  A 702 ( 3.9A)
LOG  A 702 (-3.8A)
 1.35A 1q0yH-5bxpA:
undetectable
1q0yL-5bxpA:
undetectable		 1q0yH-5bxpA:
15.99
1q0yL-5bxpA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		3 / 3 SER A 156
VAL A 173
LEU A 133
 None
 0.73A 1yajG-5bxpA:
undetectable		 1yajG-5bxpA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		4 / 6 GLY A 149
PRO A 177
LYS A 176
THR A 175
 None
 1.37A 2m2oB-5bxpA:
undetectable		 2m2oB-5bxpA:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		5 / 12 ILE A 198
SER A 194
ILE A 193
VAL A 477
ILE A 518
 None
 1.05A 2nnhA-5bxpA:
undetectable		 2nnhA-5bxpA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YK1_H_NCTH300_1
(FAB FRAGMENT, HEAVY
CHAIN
FAB FRAGMENT, LIGHT
CHAIN)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		5 / 10 ILE A 372
VAL A 390
TRP A 373
GLU A 392
TYR A 212
 None
None
LOG  A 702 ( 3.9A)
None
None
 1.39A 2yk1H-5bxpA:
undetectable
2yk1L-5bxpA:
undetectable		 2yk1H-5bxpA:
14.31
2yk1L-5bxpA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		4 / 8 HIS A 316
GLY A 318
ASN A 259
TRP A 465
 None
None
GAL  A 701 (-4.0A)
LOG  A 702 (-3.8A)
 1.23A 3ccfA-5bxpA:
undetectable		 3ccfA-5bxpA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		5 / 11 MET A 205
LEU A 215
VAL A 213
ILE A 193
PHE A 201
 None
 1.17A 3fl9C-5bxpA:
undetectable		 3fl9C-5bxpA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		5 / 11 MET A 205
ALA A 247
LEU A 215
VAL A 213
ILE A 193
 None
 1.14A 3jw5A-5bxpA:
undetectable		 3jw5A-5bxpA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		5 / 12 GLU A  93
ARG A 155
ALA A 247
ASP A 517
ASN A 248
 None
 1.33A 3jzjA-5bxpA:
undetectable		 3jzjA-5bxpA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		5 / 10 ILE A 356
ASP A 360
LYS A 364
ILE A 377
ILE A 391
 None
 1.35A 3kpbD-5bxpA:
undetectable		 3kpbD-5bxpA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		5 / 12 HIS A 263
ASP A 320
TRP A 394
TYR A 419
TRP A 465
 GAL  A 701 (-3.5A)
GAL  A 701 (-3.0A)
LOG  A 702 (-3.5A)
LOG  A 702 (-4.4A)
LOG  A 702 (-3.8A)
 0.49A 3lmyA-5bxpA:
31.4		 3lmyA-5bxpA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_B_CP6B563_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		7 / 12 HIS A 263
ASP A 320
GLU A 321
TRP A 373
TRP A 394
TYR A 419
TRP A 465
 GAL  A 701 (-3.5A)
GAL  A 701 (-3.0A)
LOG  A 702 (-3.1A)
LOG  A 702 ( 3.9A)
LOG  A 702 (-3.5A)
LOG  A 702 (-4.4A)
LOG  A 702 (-3.8A)
 0.57A 3lmyB-5bxpA:
31.3		 3lmyB-5bxpA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		4 / 5 ASN A 286
ASP A 320
GLU A 392
THR A 185
 SO4  A 704 (-3.4A)
GAL  A 701 (-3.0A)
None
None
 1.17A 3p2kC-5bxpA:
undetectable		 3p2kC-5bxpA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_1
(16S RRNA METHYLASE)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		4 / 4 ASN A 286
ASP A 320
GLU A 392
THR A 185
 SO4  A 704 (-3.4A)
GAL  A 701 (-3.0A)
None
None
 1.16A 3p2kD-5bxpA:
0.0		 3p2kD-5bxpA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		5 / 12 ASN A 413
GLY A 183
GLY A 459
LEU A 208
PHE A 201
 None
 1.44A 3r24A-5bxpA:
undetectable		 3r24A-5bxpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		4 / 8 GLY A 459
TYR A 212
GLU A 129
ARG A 371
 None
 0.95A 3s3nA-5bxpA:
2.7		 3s3nA-5bxpA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		4 / 8 THR A 621
TYR A 554
ARG A 630
LEU A 631
 None
 1.00A 3wipG-5bxpA:
undetectable
3wipH-5bxpA:
undetectable		 3wipG-5bxpA:
16.32
3wipH-5bxpA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		6 / 12 LEU A 116
VAL A  77
GLY A 153
VAL A 157
LEU A  94
THR A  95
 None
 1.35A 4m2vA-5bxpA:
undetectable		 4m2vA-5bxpA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		4 / 4 ASN A 259
GLY A 318
ASP A 350
ASP A 375
 GAL  A 701 (-4.0A)
None
None
None
 1.33A 4n49A-5bxpA:
undetectable		 4n49A-5bxpA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		5 / 12 GLY A 376
THR A 353
ASP A 375
ASP A 445
ILE A 391
 None
 1.06A 4pghD-5bxpA:
undetectable		 4pghD-5bxpA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		4 / 8 LEU A 370
GLY A 318
ALA A 319
SER A 260
 None
 0.80A 5f1aA-5bxpA:
undetectable		 5f1aA-5bxpA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		3 / 3 GLY A 345
THR A 347
ASN A 382
 None
 0.62A 5odiG-5bxpA:
4.1		 5odiG-5bxpA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		4 / 8 TRP A 610
THR A 607
THR A 627
GLN A 629
 None
 1.17A 5tzoC-5bxpA:
undetectable		 5tzoC-5bxpA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		3 / 3 ARG A 519
ARG A 486
ARG A 200
 None
 0.97A 5vcgA-5bxpA:
undetectable		 5vcgA-5bxpA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		4 / 7 GLY A 318
TRP A 465
GLN A 416
TYR A 427
 None
LOG  A 702 (-3.8A)
None
LOG  A 702 (-4.5A)
 1.21A 5vlmG-5bxpA:
undetectable		 5vlmG-5bxpA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		5 / 12 ASN A 357
GLY A 354
LEU A 404
GLY A 376
ILE A 372
 None
 1.17A 5vooD-5bxpA:
7.0		 5vooD-5bxpA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		5 / 12 ASN A 357
GLY A 354
LEU A 404
GLY A 376
ILE A 372
 None
 1.14A 5vooF-5bxpA:
3.7		 5vooF-5bxpA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		5 / 12 ASN A 357
GLY A 354
LEU A 404
GLY A 376
ILE A 372
 None
 1.19A 5vopB-5bxpA:
6.1		 5vopB-5bxpA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		3 / 3 GLU A 216
TRP A 465
HIS A 316
 GAL  A 701 (-2.8A)
LOG  A 702 (-3.8A)
None
 0.58A 5xipA-5bxpA:
3.0		 5xipA-5bxpA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		5 / 9 ALA A  87
ALA A 105
ALA A 109
GLY A 107
SER A 115
 None
 1.21A 6bklE-5bxpA:
undetectable
6bklF-5bxpA:
undetectable
6bklG-5bxpA:
undetectable
6bklH-5bxpA:
undetectable		 6bklE-5bxpA:
3.26
6bklF-5bxpA:
3.26
6bklG-5bxpA:
3.26
6bklH-5bxpA:
3.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		4 / 6 ASP A 467
GLU A 321
ASP A 320
GLU A 257
 LOG  A 702 (-2.9A)
LOG  A 702 (-3.1A)
GAL  A 701 (-3.0A)
None
 1.23A 6mn5A-5bxpA:
undetectable		 6mn5A-5bxpA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		4 / 6 ASP A 467
GLU A 321
ASP A 320
GLU A 257
 LOG  A 702 (-2.9A)
LOG  A 702 (-3.1A)
GAL  A 701 (-3.0A)
None
 1.32A 6mn5C-5bxpA:
undetectable		 6mn5C-5bxpA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		4 / 6 ASP A 467
GLU A 321
ASP A 320
GLU A 257
 LOG  A 702 (-2.9A)
LOG  A 702 (-3.1A)
GAL  A 701 (-3.0A)
None
 1.36A 6mn5D-5bxpA:
undetectable		 6mn5D-5bxpA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		4 / 7 TRP A 232
ASP A 238
THR A 236
TYR A 235
 None
 1.47A 6nmpN-5bxpA:
undetectable
6nmpP-5bxpA:
undetectable		 6nmpN-5bxpA:
20.68
6nmpP-5bxpA:
17.05