SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bxy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 5bxy RNA
METHYLTRANSFERASE
(Salinibacter
ruber) 		4 / 7 VAL A 120
SER A 121
ASN A 102
ASP A 123
 None
 1.04A 1hwiC-5bxyA:
undetectable		 1hwiC-5bxyA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 5bxy RNA
METHYLTRANSFERASE
(Salinibacter
ruber) 		4 / 7 VAL A 120
SER A 121
ASN A 102
ASP A 123
 None
 1.05A 1hwiD-5bxyA:
undetectable		 1hwiD-5bxyA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 5bxy RNA
METHYLTRANSFERASE
(Salinibacter
ruber) 		4 / 8 VAL A 120
SER A 121
ASN A 102
ASP A 123
 None
 1.07A 1hwkA-5bxyA:
undetectable		 1hwkA-5bxyA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 5bxy RNA
METHYLTRANSFERASE
(Salinibacter
ruber) 		4 / 8 VAL A 120
SER A 121
ASN A 102
ASP A 123
 None
 1.05A 1hwkC-5bxyA:
undetectable		 1hwkC-5bxyA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 5bxy RNA
METHYLTRANSFERASE
(Salinibacter
ruber) 		4 / 8 VAL A 120
SER A 121
ASN A 102
ASP A 123
 None
 1.05A 1hwkD-5bxyA:
undetectable		 1hwkD-5bxyA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5bxy RNA
METHYLTRANSFERASE
(Salinibacter
ruber) 		5 / 12 GLY A  31
GLY A  33
GLU A  53
LEU A  58
ASP A  81
 SAH  A 201 (-3.4A)
SAH  A 201 (-3.4A)
SAH  A 201 (-2.8A)
SAH  A 201 (-4.4A)
SAH  A 201 (-3.6A)
 0.31A 1jg2A-5bxyA:
10.0		 1jg2A-5bxyA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5bxy RNA
METHYLTRANSFERASE
(Salinibacter
ruber) 		5 / 11 GLY A  31
GLY A  33
GLU A  53
LEU A  58
ASP A  81
 SAH  A 201 (-3.4A)
SAH  A 201 (-3.4A)
SAH  A 201 (-2.8A)
SAH  A 201 (-4.4A)
SAH  A 201 (-3.6A)
 0.32A 1jg3A-5bxyA:
12.1		 1jg3A-5bxyA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5bxy RNA
METHYLTRANSFERASE
(Salinibacter
ruber) 		5 / 11 GLY A  31
GLY A  33
GLU A  53
LEU A  58
ASP A  81
 SAH  A 201 (-3.4A)
SAH  A 201 (-3.4A)
SAH  A 201 (-2.8A)
SAH  A 201 (-4.4A)
SAH  A 201 (-3.6A)
 0.33A 1jg3B-5bxyA:
12.1		 1jg3B-5bxyA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5bxy RNA
METHYLTRANSFERASE
(Salinibacter
ruber) 		4 / 8 GLY A  31
GLU A  53
LEU A  58
ASP A  81
 SAH  A 201 (-3.4A)
SAH  A 201 (-2.8A)
SAH  A 201 (-4.4A)
SAH  A 201 (-3.6A)
 0.32A 1jg4A-5bxyA:
12.0		 1jg4A-5bxyA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 5bxy RNA
METHYLTRANSFERASE
(Salinibacter
ruber) 		6 / 12 GLY A  31
GLY A  33
ILE A  54
ASP A  55
LEU A  58
ASP A  81
 SAH  A 201 (-3.4A)
SAH  A 201 (-3.4A)
SAH  A 201 (-3.9A)
None
SAH  A 201 (-4.4A)
SAH  A 201 (-3.6A)
 0.61A 1qaoA-5bxyA:
12.2		 1qaoA-5bxyA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5bxy RNA
METHYLTRANSFERASE
(Salinibacter
ruber) 		5 / 12 ILE A  37
ALA A  41
ASN A  65
LEU A  27
ALA A  47
 None
 1.11A 1xdkA-5bxyA:
undetectable		 1xdkA-5bxyA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 5bxy RNA
METHYLTRANSFERASE
(Salinibacter
ruber) 		4 / 5 PRO A  99
VAL A 101
ASN A 102
VAL A   2
 None
None
None
SAH  A 201 (-4.2A)
 1.03A 1z2bC-5bxyA:
2.5		 1z2bC-5bxyA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5bxy RNA
METHYLTRANSFERASE
(Salinibacter
ruber) 		5 / 12 ASP A  29
GLY A  31
GLY A  33
ASP A  55
LEU A  97
 SAH  A 201 (-2.9A)
SAH  A 201 (-3.4A)
SAH  A 201 (-3.4A)
None
None
 0.67A 2nxeB-5bxyA:
17.4		 2nxeB-5bxyA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5bxy RNA
METHYLTRANSFERASE
(Salinibacter
ruber) 		5 / 12 ASP A  29
GLY A  31
GLY A  33
ILE A  54
ASP A  55
 SAH  A 201 (-2.9A)
SAH  A 201 (-3.4A)
SAH  A 201 (-3.4A)
SAH  A 201 (-3.9A)
None
 0.56A 2nxeB-5bxyA:
17.4		 2nxeB-5bxyA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 5bxy RNA
METHYLTRANSFERASE
(Salinibacter
ruber) 		4 / 5 ILE A  39
ARG A  40
ARG A  36
ASP A  34
 None
 0.86A 2rhmB-5bxyA:
undetectable		 2rhmB-5bxyA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_D_BEZD194_0
(PUTATIVE KINASE)		 5bxy RNA
METHYLTRANSFERASE
(Salinibacter
ruber) 		4 / 5 ILE A  39
ARG A  40
ARG A  36
ASP A  34
 None
 1.05A 2rhmD-5bxyA:
undetectable		 2rhmD-5bxyA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5bxy RNA
METHYLTRANSFERASE
(Salinibacter
ruber) 		4 / 8 TYR A   4
LEU A  58
LYS A  60
ALA A  62
 SAH  A 201 (-4.7A)
SAH  A 201 (-4.4A)
None
None
 0.97A 2wekA-5bxyA:
8.6		 2wekA-5bxyA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 5bxy RNA
METHYLTRANSFERASE
(Salinibacter
ruber) 		4 / 6 GLY A  31
ILE A  52
GLU A  53
ILE A  54
 SAH  A 201 (-3.4A)
None
SAH  A 201 (-2.8A)
SAH  A 201 (-3.9A)
 0.57A 3a7eA-5bxyA:
14.9		 3a7eA-5bxyA:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5bxy RNA
METHYLTRANSFERASE
(Salinibacter
ruber) 		5 / 12 LEU A  82
GLY A  31
GLY A  33
ASP A  55
LEU A  97
 SAH  A 201 (-3.8A)
SAH  A 201 (-3.4A)
SAH  A 201 (-3.4A)
None
None
 1.09A 3cjtG-5bxyA:
17.1		 3cjtG-5bxyA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5bxy RNA
METHYLTRANSFERASE
(Salinibacter
ruber) 		5 / 11 GLY A  31
GLY A  33
ILE A  52
GLU A  53
ASP A  81
 SAH  A 201 (-3.4A)
SAH  A 201 (-3.4A)
None
SAH  A 201 (-2.8A)
SAH  A 201 (-3.6A)
 0.63A 3dxyA-5bxyA:
11.6		 3dxyA-5bxyA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 5bxy RNA
METHYLTRANSFERASE
(Salinibacter
ruber) 		5 / 12 GLY A  31
GLY A  33
GLU A  53
ASP A  55
ASP A  81
 SAH  A 201 (-3.4A)
SAH  A 201 (-3.4A)
SAH  A 201 (-2.8A)
None
SAH  A 201 (-3.6A)
 0.65A 3fuuA-5bxyA:
14.5		 3fuuA-5bxyA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 5bxy RNA
METHYLTRANSFERASE
(Salinibacter
ruber) 		7 / 11 GLY A  31
GLY A  33
GLU A  53
ILE A  54
ASP A  55
LEU A  58
ASP A  81
 SAH  A 201 (-3.4A)
SAH  A 201 (-3.4A)
SAH  A 201 (-2.8A)
SAH  A 201 (-3.9A)
None
SAH  A 201 (-4.4A)
SAH  A 201 (-3.6A)
 0.87A 3grvA-5bxyA:
15.2		 3grvA-5bxyA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 5bxy RNA
METHYLTRANSFERASE
(Salinibacter
ruber) 		6 / 12 GLY A  31
GLU A  53
ILE A  54
ASP A  55
LEU A  58
ASP A  81
 SAH  A 201 (-3.4A)
SAH  A 201 (-2.8A)
SAH  A 201 (-3.9A)
None
SAH  A 201 (-4.4A)
SAH  A 201 (-3.6A)
 0.60A 3gryA-5bxyA:
14.9		 3gryA-5bxyA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 5bxy RNA
METHYLTRANSFERASE
(Salinibacter
ruber) 		6 / 12 GLY A  31
GLY A  33
ILE A  54
ASP A  55
LEU A  58
ASP A  81
 SAH  A 201 (-3.4A)
SAH  A 201 (-3.4A)
SAH  A 201 (-3.9A)
None
SAH  A 201 (-4.4A)
SAH  A 201 (-3.6A)
 0.97A 3gryA-5bxyA:
14.9		 3gryA-5bxyA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 5bxy RNA
METHYLTRANSFERASE
(Salinibacter
ruber) 		3 / 3 THR A   7
ASP A  29
GLU A  53
 SAH  A 201 (-3.5A)
SAH  A 201 (-2.9A)
SAH  A 201 (-2.8A)
 0.34A 3qowA-5bxyA:
15.6		 3qowA-5bxyA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 5bxy RNA
METHYLTRANSFERASE
(Salinibacter
ruber) 		4 / 6 GLY A  33
GLU A  53
ASP A  81
ASP A  29
 SAH  A 201 (-3.4A)
SAH  A 201 (-2.8A)
SAH  A 201 (-3.6A)
SAH  A 201 (-2.9A)
 0.91A 3vywC-5bxyA:
10.1		 3vywC-5bxyA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 5bxy RNA
METHYLTRANSFERASE
(Salinibacter
ruber) 		4 / 8 ASP A 123
VAL A   5
HIS A 122
TYR A  96
 None
 1.23A 4f5zA-5bxyA:
undetectable		 4f5zA-5bxyA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 5bxy RNA
METHYLTRANSFERASE
(Salinibacter
ruber) 		3 / 3 GLU A  53
ASP A  55
ASP A  81
 SAH  A 201 (-2.8A)
None
SAH  A 201 (-3.6A)
 0.48A 4gc9A-5bxyA:
11.7		 4gc9A-5bxyA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 5bxy RNA
METHYLTRANSFERASE
(Salinibacter
ruber) 		4 / 7 GLY A  31
GLY A  33
GLU A  53
ASP A  81
 SAH  A 201 (-3.4A)
SAH  A 201 (-3.4A)
SAH  A 201 (-2.8A)
SAH  A 201 (-3.6A)
 0.68A 5ergB-5bxyA:
14.4		 5ergB-5bxyA:
17.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 5bxy RNA
METHYLTRANSFERASE
(Salinibacter
ruber) 		6 / 12 PRO A   6
GLY A  31
GLY A  33
ARG A  36
ILE A  37
ILE A  54
 SAH  A 201 (-4.4A)
SAH  A 201 (-3.4A)
SAH  A 201 (-3.4A)
None
None
SAH  A 201 (-3.9A)
 0.22A 5fa8A-5bxyA:
26.8		 5fa8A-5bxyA:
46.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 5bxy RNA
METHYLTRANSFERASE
(Salinibacter
ruber) 		3 / 3 THR A   7
ASP A  29
GLU A  53
 SAH  A 201 (-3.5A)
SAH  A 201 (-2.9A)
SAH  A 201 (-2.8A)
 0.12A 5fa8A-5bxyA:
26.8		 5fa8A-5bxyA:
46.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 5bxy RNA
METHYLTRANSFERASE
(Salinibacter
ruber) 		5 / 12 GLY A  31
GLY A  33
ILE A  54
ASP A  55
LEU A  58
 SAH  A 201 (-3.4A)
SAH  A 201 (-3.4A)
SAH  A 201 (-3.9A)
None
SAH  A 201 (-4.4A)
 0.65A 6iftA-5bxyA:
13.3		 6iftA-5bxyA:
20.07