SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5by2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5by2 PHOSPHOHEPTOSE
ISOMERASE
(Colwellia
psychrerythraea) 		5 / 12 ILE A  86
GLY A  48
ALA A 141
SER A 122
TYR A  95
 None
 1.19A 1nbhA-5by2A:
undetectable		 1nbhA-5by2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5by2 PHOSPHOHEPTOSE
ISOMERASE
(Colwellia
psychrerythraea) 		5 / 12 ILE A  86
GLY A  48
ALA A 141
SER A 122
TYR A  95
 None
 1.21A 1nbhD-5by2A:
2.4		 1nbhD-5by2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 5by2 PHOSPHOHEPTOSE
ISOMERASE
(Colwellia
psychrerythraea) 		6 / 12 GLY A  48
GLY A  50
THR A 118
ALA A 115
ALA A  56
HIS A  55
 None
 1.25A 2gluB-5by2A:
undetectable		 2gluB-5by2A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5by2 PHOSPHOHEPTOSE
ISOMERASE
(Colwellia
psychrerythraea) 		3 / 3 SER A 134
GLU A  97
ASP A  92
 None
 0.81A 2zulA-5by2A:
3.0		 2zulA-5by2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 5by2 PHOSPHOHEPTOSE
ISOMERASE
(Colwellia
psychrerythraea) 		4 / 8 LEU A 182
CYH A 183
PHE A  59
TYR A  67
 None
 1.00A 4j7uD-5by2A:
3.9		 4j7uD-5by2A:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_I_PACI601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 5by2 PHOSPHOHEPTOSE
ISOMERASE
(Colwellia
psychrerythraea) 		5 / 12 SER A 181
ILE A 161
HIS A 175
VAL A 177
VAL A 174
 None
 1.43A 4yfbI-5by2A:
undetectable		 4yfbI-5by2A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 5by2 PHOSPHOHEPTOSE
ISOMERASE
(Colwellia
psychrerythraea) 		5 / 12 ILE A 171
GLY A 147
ILE A 150
ILE A  27
ALA A  30
 None
 1.03A 5e72A-5by2A:
2.6		 5e72A-5by2A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5by2 PHOSPHOHEPTOSE
ISOMERASE
(Colwellia
psychrerythraea) 		5 / 10 GLY A 157
GLY A 155
LEU A 114
ILE A 129
LEU A 113
 None
 1.06A 5vm8B-5by2A:
undetectable		 5vm8B-5by2A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5by2 PHOSPHOHEPTOSE
ISOMERASE
(Colwellia
psychrerythraea) 		5 / 12 GLY A  48
LEU A  23
GLY A 144
SER A 119
ILE A 171
 None
 1.15A 5vooA-5by2A:
2.3		 5vooA-5by2A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5by2 PHOSPHOHEPTOSE
ISOMERASE
(Colwellia
psychrerythraea) 		5 / 12 GLY A  48
LEU A  23
GLY A 144
SER A 119
ILE A 171
 None
 1.16A 5vooB-5by2A:
2.2		 5vooB-5by2A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5by2 PHOSPHOHEPTOSE
ISOMERASE
(Colwellia
psychrerythraea) 		5 / 12 GLY A  48
LEU A  23
GLY A 144
SER A 119
ILE A 171
 None
 1.13A 5vooC-5by2A:
undetectable		 5vooC-5by2A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5by2 PHOSPHOHEPTOSE
ISOMERASE
(Colwellia
psychrerythraea) 		5 / 12 GLY A  48
LEU A  23
GLY A 144
SER A 119
ILE A 171
 None
 1.17A 5vooD-5by2A:
undetectable		 5vooD-5by2A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5by2 PHOSPHOHEPTOSE
ISOMERASE
(Colwellia
psychrerythraea) 		5 / 12 GLY A  48
LEU A  23
GLY A 144
SER A 119
ILE A 171
 None
 1.13A 5vooE-5by2A:
undetectable		 5vooE-5by2A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5by2 PHOSPHOHEPTOSE
ISOMERASE
(Colwellia
psychrerythraea) 		5 / 12 GLY A  48
LEU A  23
GLY A 144
SER A 119
ILE A 171
 None
 1.18A 5vooF-5by2A:
undetectable		 5vooF-5by2A:
20.07