SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5by8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5by8 RPF2
(Aspergillus
nidulans) 		4 / 5 THR A 197
GLU A 195
HIS A 205
HIS A 161
 None
 1.28A 1d4fA-5by8A:
undetectable		 1d4fA-5by8A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5by8 RPF2
(Aspergillus
nidulans) 		4 / 5 THR A 197
GLU A 195
HIS A 205
HIS A 161
 None
 1.29A 1d4fD-5by8A:
undetectable		 1d4fD-5by8A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RR8_A_TTCA100_1
(DNA TOPOISOMERASE I)		 5by8 RPF2
RRS1
(Aspergillus
nidulans) 		4 / 5 GLU A 241
ARG A 105
ASP A 170
THR B  93
 None
 1.31A 1rr8C-5by8A:
undetectable		 1rr8C-5by8A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RRJ_B_TTCB990_1
(DNA TOPOISOMERASE I)		 5by8 RPF2
RRS1
(Aspergillus
nidulans) 		4 / 5 GLU A 241
ARG A 105
ASP A 170
THR B  93
 None
 1.34A 1rrjA-5by8A:
undetectable		 1rrjA-5by8A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 5by8 RPF2
RRS1
(Aspergillus
nidulans) 		4 / 5 LEU B  88
LEU B  33
LEU B  37
LEU A 145
 None
 1.03A 2ab2B-5by8B:
undetectable		 2ab2B-5by8B:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5by8 RPF2
(Aspergillus
nidulans) 		5 / 11 LEU A 189
LEU A 171
LYS A 173
HIS A  56
PRO A 144
 None
 1.49A 2x7hA-5by8A:
undetectable
2x7hB-5by8A:
undetectable		 2x7hA-5by8A:
21.43
2x7hB-5by8A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5by8 RPF2
RRS1
(Aspergillus
nidulans;
Aspergillus
nidulans) 		5 / 12 GLY A 192
LEU A 147
ILE A 203
LEU B  56
LEU B  52
 None
 1.18A 3cjtG-5by8A:
undetectable		 3cjtG-5by8A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5by8 RPF2
RRS1
(Aspergillus
nidulans;
Aspergillus
nidulans) 		4 / 4 GLY A 150
GLU A 195
ASP A 155
ASP B  40
 None
 1.10A 3mb5A-5by8A:
undetectable		 3mb5A-5by8A:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 5by8 RPF2
RRS1
(Aspergillus
nidulans) 		5 / 12 ILE A 103
LEU A 171
LEU A  32
ILE B  94
PRO B  96
 None
 1.15A 3ozwB-5by8A:
undetectable		 3ozwB-5by8A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5by8 RPF2
RRS1
(Aspergillus
nidulans;
Aspergillus
nidulans) 		5 / 12 HIS A 218
LEU A 220
ALA A 188
ASN B  69
LEU A 147
 None
 1.31A 3tm4A-5by8A:
undetectable		 3tm4A-5by8A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5by8 RPF2
RRS1
(Aspergillus
nidulans;
Aspergillus
nidulans) 		5 / 12 HIS A 218
LEU A 220
ALA A 188
ASN B  69
LEU A 147
 None
 1.29A 3tm4B-5by8A:
undetectable		 3tm4B-5by8A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 5by8 RPF2
(Aspergillus
nidulans) 		3 / 3 VAL A  30
SER A  57
THR A  53
 None
 0.42A 4luhA-5by8A:
undetectable		 4luhA-5by8A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 5by8 RPF2
RRS1
(Aspergillus
nidulans) 		4 / 6 ASP A 122
GLU A 126
ASN B  53
ARG A 207
 None
 1.29A 4ntxA-5by8A:
undetectable
4ntxC-5by8A:
undetectable		 4ntxA-5by8A:
18.44
4ntxC-5by8A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 5by8 RPF2
(Aspergillus
nidulans) 		4 / 8 LEU A 206
LEU A 171
MET A 167
LEU A 101
 None
 0.92A 5dxeA-5by8A:
undetectable		 5dxeA-5by8A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 5by8 RPF2
(Aspergillus
nidulans) 		4 / 5 LEU A 171
LEU A 164
PHE A 172
LEU A 206
 None
 0.84A 5gtrA-5by8A:
undetectable		 5gtrA-5by8A:
21.51