SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bym'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 5bym SUPPRESSOR PROTEIN
MPT5
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 243
ASN A 239
MET A 245
LEU A 265
 None
 0.87A 1lhvA-5bymA:
undetectable		 1lhvA-5bymA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 5bym SUPPRESSOR PROTEIN
MPT5
(Saccharomyces
cerevisiae) 		6 / 12 ILE A 361
ALA A 363
SER A 374
ILE A 418
LEU A 387
ILE A 398
 None
 1.39A 1rb3B-5bymA:
undetectable		 1rb3B-5bymA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_B_ANWB99_0
(PROTEIN S100-A13)		 5bym SUPPRESSOR PROTEIN
MPT5
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 486
PHE A 471
THR A 469
ASP A 488
 None
 1.27A 2kotB-5bymA:
undetectable		 2kotB-5bymA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5bym SUPPRESSOR PROTEIN
MPT5
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 292
ILE A 318
CYH A 348
VAL A 344
PHE A 359
 None
 1.09A 2qo5A-5bymA:
undetectable		 2qo5A-5bymA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 5bym SUPPRESSOR PROTEIN
MPT5
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 447
SER A 454
ILE A 410
PHE A 414
 None
G  C   2 ( 4.4A)
None
A  C   4 ( 4.5A)
 0.75A 3ko0B-5bymA:
undetectable		 3ko0B-5bymA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 5bym SUPPRESSOR PROTEIN
MPT5
(Saccharomyces
cerevisiae) 		5 / 11 SER A 206
ILE A 205
ASP A 221
GLY A 224
PHE A 227
 None
 1.28A 4fogC-5bymA:
undetectable		 4fogC-5bymA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 5bym SUPPRESSOR PROTEIN
MPT5
(Saccharomyces
cerevisiae) 		5 / 12 SER A 206
ILE A 205
ASP A 221
GLY A 224
PHE A 227
 None
 1.38A 4foxE-5bymA:
undetectable		 4foxE-5bymA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 5bym SUPPRESSOR PROTEIN
MPT5
(Saccharomyces
cerevisiae) 		5 / 11 SER A 206
ILE A 205
ASP A 221
GLY A 224
PHE A 227
 None
 1.26A 4foxH-5bymA:
undetectable		 4foxH-5bymA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 5bym SUPPRESSOR PROTEIN
MPT5
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 502
ALA A 521
LEU A 525
THR A 524
LEU A 498
 None
 1.13A 4g1bB-5bymA:
undetectable		 4g1bB-5bymA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5bym SUPPRESSOR PROTEIN
MPT5
(Saccharomyces
cerevisiae) 		4 / 5 GLN A 384
LEU A 387
SER A 388
ASP A 307
 A  C   4 ( 3.4A)
None
None
None
 1.32A 4qtuD-5bymA:
undetectable		 4qtuD-5bymA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5bym SUPPRESSOR PROTEIN
MPT5
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 569
GLY A 566
PHE A 465
TYR A 531
VAL A 528
 None
 1.18A 5hw4A-5bymA:
undetectable		 5hw4A-5bymA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5bym SUPPRESSOR PROTEIN
MPT5
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 569
GLY A 566
PHE A 465
TYR A 531
VAL A 528
 None
 1.21A 5hw4B-5bymA:
undetectable		 5hw4B-5bymA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5bym SUPPRESSOR PROTEIN
MPT5
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 569
GLY A 566
PHE A 465
TYR A 531
VAL A 528
 None
 1.18A 5hw4C-5bymA:
undetectable		 5hw4C-5bymA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 5bym SUPPRESSOR PROTEIN
MPT5
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 336
ALA A 363
ILE A 360
ILE A 398
LEU A 386
 None
 1.09A 5mvmA-5bymA:
undetectable
5mvmE-5bymA:
undetectable		 5mvmA-5bymA:
11.20
5mvmE-5bymA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5bym SUPPRESSOR PROTEIN
MPT5
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 302
SER A 293
LEU A 335
ASP A 338
ILE A 257
 None
 1.43A 6dm2B-5bymA:
undetectable
6dm2C-5bymA:
undetectable		 6dm2B-5bymA:
9.73
6dm2C-5bymA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5bym SUPPRESSOR PROTEIN
MPT5
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 257
LEU A 302
SER A 293
LEU A 335
ASP A 338
 None
 1.43A 6dm2A-5bymA:
undetectable
6dm2D-5bymA:
undetectable		 6dm2A-5bymA:
9.73
6dm2D-5bymA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5bym SUPPRESSOR PROTEIN
MPT5
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 387
SER A 374
GLY A 379
ILE A 373
ILE A 402
 None
 1.21A 6ebpA-5bymA:
undetectable		 6ebpA-5bymA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5bym SUPPRESSOR PROTEIN
MPT5
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 387
SER A 374
GLY A 379
ILE A 373
ILE A 402
 None
 1.22A 6ebpB-5bymA:
undetectable		 6ebpB-5bymA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5bym SUPPRESSOR PROTEIN
MPT5
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 387
SER A 374
GLY A 379
ILE A 373
ILE A 402
 None
 1.20A 6ebpC-5bymA:
undetectable		 6ebpC-5bymA:
11.98