SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bz0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 5bz0 REPLICASE
POLYPROTEIN 1AB
(Avian
coronavirus) 		4 / 8 GLY A 252
ASP A 247
TYR A 294
THR A 202
 None
 0.87A 2aouA-5bz0A:
undetectable		 2aouA-5bz0A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 5bz0 REPLICASE
POLYPROTEIN 1AB
(Avian
coronavirus) 		4 / 7 GLY A 252
ASP A 247
TYR A 294
THR A 202
 None
 0.87A 2aouB-5bz0A:
undetectable		 2aouB-5bz0A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 5bz0 REPLICASE
POLYPROTEIN 1AB
(Avian
coronavirus) 		5 / 11 LEU A 230
ALA A 292
LEU A 204
ASP A 247
ASP A 249
 None
 1.16A 2q72A-5bz0A:
undetectable		 2q72A-5bz0A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 5bz0 REPLICASE
POLYPROTEIN 1AB
(Avian
coronavirus) 		4 / 7 ASN A 100
LEU A  94
TYR A 141
TRP A 102
 None
 1.09A 2uz2A-5bz0A:
undetectable		 2uz2A-5bz0A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 5bz0 REPLICASE
POLYPROTEIN 1AB
(Avian
coronavirus) 		4 / 7 LEU A 110
GLN A 111
PHE A 117
LEU A 161
 None
 1.02A 3ag2C-5bz0A:
undetectable		 3ag2C-5bz0A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5bz0 REPLICASE
POLYPROTEIN 1AB
(Avian
coronavirus) 		5 / 12 PHE A 136
PHE A 117
LEU A 110
ALA A 159
SER A 143
 None
 1.46A 3apwB-5bz0A:
undetectable		 3apwB-5bz0A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 5bz0 REPLICASE
POLYPROTEIN 1AB
(Avian
coronavirus) 		4 / 7 LEU A 230
ASP A 168
ALA A 167
TYR A 169
 None
 1.17A 3rodD-5bz0A:
undetectable		 3rodD-5bz0A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 5bz0 REPLICASE
POLYPROTEIN 1AB
(Avian
coronavirus) 		3 / 3 ASN A  84
GLU A  95
ARG A  97
 None
 1.05A 3wxoA-5bz0A:
undetectable		 3wxoA-5bz0A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 5bz0 REPLICASE
POLYPROTEIN 1AB
(Avian
coronavirus) 		3 / 3 THR A 291
THR A 202
PHE A 207
 None
 0.91A 5cxvA-5bz0A:
undetectable		 5cxvA-5bz0A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5bz0 REPLICASE
POLYPROTEIN 1AB
(Avian
coronavirus) 		4 / 5 GLY A  99
ASN A 100
ASP A  98
ARG A  97
 None
 1.35A 6dwdB-5bz0A:
undetectable
6dwdD-5bz0A:
undetectable		 6dwdB-5bz0A:
19.38
6dwdD-5bz0A:
19.38