SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bz3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5bz3 NA(+)/H(+)
ANTIPORTER
(Thermus
thermophilus) 		5 / 12 GLY A 193
SER A 199
LEU A 229
MET A 226
LEU A  77
 None
None
7E8  A 404 ( 3.2A)
7E8  A 404 (-4.0A)
None
 1.14A 1fm6D-5bz3A:
undetectable		 1fm6D-5bz3A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 5bz3 NA(+)/H(+)
ANTIPORTER
(Thermus
thermophilus) 		4 / 8 LEU A 365
PRO A  44
VAL A  40
GLY A  39
 None
 0.77A 1hrkA-5bz3A:
undetectable		 1hrkA-5bz3A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 5bz3 NA(+)/H(+)
ANTIPORTER
(Thermus
thermophilus) 		4 / 8 LEU A 365
PRO A  44
VAL A  40
GLY A  39
 None
 0.78A 1hrkB-5bz3A:
undetectable		 1hrkB-5bz3A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 5bz3 NA(+)/H(+)
ANTIPORTER
(Thermus
thermophilus) 		4 / 8 VAL A 278
TYR A  12
GLY A  39
LEU A  56
 None
 1.03A 1s1xA-5bz3A:
undetectable		 1s1xA-5bz3A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5bz3 NA(+)/H(+)
ANTIPORTER
(Thermus
thermophilus) 		5 / 12 GLY A 129
LEU A  67
VAL A  36
PRO A 368
ILE A  33
 None
 1.23A 1zq9A-5bz3A:
undetectable		 1zq9A-5bz3A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5bz3 NA(+)/H(+)
ANTIPORTER
(Thermus
thermophilus) 		4 / 5 GLY A 217
PRO A 260
ALA A 263
ILE A 264
 None
 0.89A 2aofA-5bz3A:
undetectable		 2aofA-5bz3A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 5bz3 NA(+)/H(+)
ANTIPORTER
(Thermus
thermophilus) 		4 / 8 ALA A  16
ALA A 274
LEU A  49
VAL A  50
 None
 0.83A 2bxgA-5bz3A:
undetectable		 2bxgA-5bz3A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5bz3 NA(+)/H(+)
ANTIPORTER
(Thermus
thermophilus) 		4 / 8 LEU A 365
PRO A  44
VAL A  40
GLY A  39
 None
 0.79A 2po5A-5bz3A:
undetectable		 2po5A-5bz3A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5bz3 NA(+)/H(+)
ANTIPORTER
(Thermus
thermophilus) 		4 / 6 PHE A 218
ILE A 202
GLY A 244
GLY A 245
 None
 0.83A 2qx6A-5bz3A:
undetectable
2qx6B-5bz3A:
undetectable		 2qx6A-5bz3A:
21.07
2qx6B-5bz3A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA803_1
(CATALASE-PEROXIDASE)		 5bz3 NA(+)/H(+)
ANTIPORTER
(Thermus
thermophilus) 		4 / 4 ASP A  79
THR A  75
VAL A  83
SER A 142
 None
None
None
7E8  A 402 ( 3.8A)
 0.80A 3wxoA-5bz3A:
0.1		 3wxoA-5bz3A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5bz3 NA(+)/H(+)
ANTIPORTER
(Thermus
thermophilus) 		4 / 7 VAL A 334
VAL A 338
LEU A 341
VAL A 170
 None
 0.83A 4e1gB-5bz3A:
undetectable		 4e1gB-5bz3A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 5bz3 NA(+)/H(+)
ANTIPORTER
(Thermus
thermophilus) 		4 / 7 GLY A 217
ILE A 261
LEU A 248
PHE A  69
 None
 0.82A 4ejjD-5bz3A:
undetectable		 4ejjD-5bz3A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 5bz3 NA(+)/H(+)
ANTIPORTER
(Thermus
thermophilus) 		5 / 12 ALA A 152
GLY A 325
GLY A 327
LEU A 374
LEU A 371
 None
 1.12A 4lg1B-5bz3A:
undetectable		 4lg1B-5bz3A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 5bz3 NA(+)/H(+)
ANTIPORTER
(Thermus
thermophilus) 		6 / 9 LEU A 248
LEU A 243
GLY A 244
LEU A 247
LEU A 198
ALA A 195
 None
 1.44A 5dqfA-5bz3A:
undetectable		 5dqfA-5bz3A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5bz3 NA(+)/H(+)
ANTIPORTER
(Thermus
thermophilus) 		4 / 7 GLU A  57
GLY A 277
GLY A  43
ALA A 274
 7E8  A 401 ( 4.1A)
None
None
None
 0.83A 5e26A-5bz3A:
undetectable
5e26B-5bz3A:
undetectable		 5e26A-5bz3A:
22.84
5e26B-5bz3A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5bz3 NA(+)/H(+)
ANTIPORTER
(Thermus
thermophilus) 		4 / 7 ALA A 274
GLU A  57
GLY A 277
GLY A  43
 None
7E8  A 401 ( 4.1A)
None
None
 0.81A 5e26A-5bz3A:
undetectable
5e26B-5bz3A:
undetectable		 5e26A-5bz3A:
22.84
5e26B-5bz3A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5bz3 NA(+)/H(+)
ANTIPORTER
(Thermus
thermophilus) 		4 / 7 GLU A  57
GLY A 277
GLY A  43
ALA A 274
 7E8  A 401 ( 4.1A)
None
None
None
 0.83A 5e26C-5bz3A:
undetectable
5e26D-5bz3A:
undetectable		 5e26C-5bz3A:
22.84
5e26D-5bz3A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5bz3 NA(+)/H(+)
ANTIPORTER
(Thermus
thermophilus) 		4 / 8 ALA A 274
GLU A  57
GLY A 277
GLY A  43
 None
7E8  A 401 ( 4.1A)
None
None
 0.85A 5e26C-5bz3A:
undetectable
5e26D-5bz3A:
undetectable		 5e26C-5bz3A:
22.84
5e26D-5bz3A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 5bz3 NA(+)/H(+)
ANTIPORTER
(Thermus
thermophilus) 		5 / 10 ILE A 261
PRO A 260
LEU A 220
VAL A 212
LEU A 207
 None
 1.17A 5ienB-5bz3A:
undetectable		 5ienB-5bz3A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 5bz3 NA(+)/H(+)
ANTIPORTER
(Thermus
thermophilus) 		4 / 6 PRO A  98
LEU A  97
PHE A  99
LEU A 123
 None
 1.02A 5tl8A-5bz3A:
undetectable		 5tl8A-5bz3A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5bz3 NA(+)/H(+)
ANTIPORTER
(Thermus
thermophilus) 		3 / 3 ARG A 183
LEU A 187
PHE A 191
 7E8  A 404 ( 2.6A)
7E8  A 404 ( 4.2A)
None
 0.64A 6nknP-5bz3A:
undetectable		 6nknP-5bz3A:
23.08