SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bz4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 LEU A  55
ILE A  54
LEU A  39
VAL A 267
ALA A 100
 None
 1.21A 1e7aA-5bz4A:
undetectable		 1e7aA-5bz4A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 VAL A 240
LEU A 234
GLY A 253
ALA A 252
SER A 255
 None
 1.14A 1pxxA-5bz4A:
undetectable		 1pxxA-5bz4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 VAL A 240
LEU A 234
GLY A 253
ALA A 252
SER A 255
 None
 1.14A 1pxxB-5bz4A:
undetectable		 1pxxB-5bz4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLU A 387
ALA A 114
GLY A  91
GLY A 366
ILE A 391
 None
 1.10A 1x1aA-5bz4A:
undetectable		 1x1aA-5bz4A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 GLY A  17
GLU A 223
ASP A 260
 None
 0.67A 2b25B-5bz4A:
undetectable		 2b25B-5bz4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 116
GLY A 366
GLY A  93
ALA A  96
ASN A 325
 None
 1.08A 2dpmA-5bz4A:
undetectable		 2dpmA-5bz4A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 GLY A 366
SER A  92
THR A 365
HIS A 360
PHE A 328
 None
 1.44A 2hmaA-5bz4A:
undetectable		 2hmaA-5bz4A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 276
LEU A 111
LEU A  77
PRO A  78
VAL A  81
 None
 0.98A 2hrcB-5bz4A:
undetectable		 2hrcB-5bz4A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  31
LEU A  39
GLY A  56
HIS A  57
LEU A  55
 None
 0.95A 2ouzA-5bz4A:
undetectable		 2ouzA-5bz4A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 4 LEU A 234
GLN A 190
THR A 229
THR A 179
 None
 1.46A 2zj0D-5bz4A:
undetectable		 2zj0D-5bz4A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW1_A_STIA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 PHE A 401
GLY A  93
GLY A 366
THR A 365
MET A 369
 None
 1.44A 3fw1A-5bz4A:
undetectable		 3fw1A-5bz4A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLU A 323
SER A 256
ILE A 356
LEU A 184
ARG A 187
 None
 1.13A 3ia4A-5bz4A:
undetectable		 3ia4A-5bz4A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLU A 323
SER A 256
ILE A 356
LEU A 184
ARG A 187
 None
 1.17A 3ia4C-5bz4A:
undetectable		 3ia4C-5bz4A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLU A 323
SER A 256
ILE A 356
LEU A 184
ARG A 187
 None
 1.16A 3ia4D-5bz4A:
undetectable		 3ia4D-5bz4A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A  72
LEU A  36
LEU A  55
GLN A  85
VAL A 112
 None
 1.19A 3ix9B-5bz4A:
undetectable		 3ix9B-5bz4A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 GLU A 326
ASN A 325
ASN A 350
ILE A 322
 None
 1.35A 3kp6A-5bz4A:
undetectable
3kp6B-5bz4A:
undetectable		 3kp6A-5bz4A:
15.62
3kp6B-5bz4A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A 377
ASP A 320
ARG A 383
ALA A 382
 None
 1.12A 3mbgA-5bz4A:
undetectable
3mbgB-5bz4A:
undetectable		 3mbgA-5bz4A:
17.05
3mbgB-5bz4A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA500_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 4 ALA A 192
HIS A 189
HIS A 224
PRO A 225
 None
 1.16A 3mbgA-5bz4A:
0.7		 3mbgA-5bz4A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC900_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 4 ALA A 192
HIS A 189
HIS A 224
PRO A 225
 None
 1.17A 3mbgC-5bz4A:
0.7		 3mbgC-5bz4A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 TYR A  59
GLY A 144
ASP A 143
 None
 0.64A 3ou6C-5bz4A:
undetectable		 3ou6C-5bz4A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  31
ALA A  35
GLY A  56
HIS A  57
LEU A  55
 None
 1.07A 3q95A-5bz4A:
undetectable		 3q95A-5bz4A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A 358
GLY A 367
GLU A 387
ALA A 371
 None
 0.92A 3tehB-5bz4A:
undetectable		 3tehB-5bz4A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 290
GLY A 394
ALA A 327
PRO A 301
LEU A 324
 None
 1.21A 3tm4A-5bz4A:
undetectable		 3tm4A-5bz4A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 290
GLY A 394
ALA A 327
PRO A 301
LEU A 324
 None
 1.19A 3tm4B-5bz4A:
2.2		 3tm4B-5bz4A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 LEU A  31
ALA A  35
GLY A  56
HIS A  57
LEU A  55
 None
 1.06A 3uudA-5bz4A:
undetectable		 3uudA-5bz4A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 240
LEU A 234
GLY A 253
ALA A 252
SER A 255
 None
 1.04A 4coxA-5bz4A:
undetectable		 4coxA-5bz4A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 240
LEU A 234
GLY A 253
ALA A 252
SER A 255
 None
 1.05A 4coxB-5bz4A:
undetectable		 4coxB-5bz4A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 240
LEU A 234
GLY A 253
ALA A 252
SER A 255
 None
 1.04A 4coxD-5bz4A:
undetectable		 4coxD-5bz4A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 ARG A  42
PRO A 225
SER A 357
VAL A 221
 None
 1.12A 4klrA-5bz4A:
2.1		 4klrA-5bz4A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		6 / 12 VAL A  12
ALA A 262
LEU A  55
LEU A  36
LYS A  37
THR A  14
 None
 1.40A 4ky8A-5bz4A:
undetectable		 4ky8A-5bz4A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		6 / 12 VAL A  12
ALA A 262
LEU A  55
LEU A  36
LYS A  37
THR A  14
 None
 1.37A 4ky8D-5bz4A:
undetectable		 4ky8D-5bz4A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 240
LEU A 234
GLY A 253
ALA A 252
SER A 255
 None
 0.96A 4otyA-5bz4A:
undetectable		 4otyA-5bz4A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 240
LEU A 234
GLY A 253
ALA A 252
SER A 255
 None
 0.99A 4otyB-5bz4A:
undetectable		 4otyB-5bz4A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 ALA A 398
THR A 305
ALA A 308
ILE A 391
GLY A 300
 None
 1.15A 4qvqK-5bz4A:
undetectable
4qvqL-5bz4A:
undetectable		 4qvqK-5bz4A:
20.33
4qvqL-5bz4A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 ALA A 398
THR A 305
ALA A 308
ILE A 391
GLY A 300
 None
 1.15A 4qvqY-5bz4A:
undetectable
4qvqZ-5bz4A:
undetectable		 4qvqY-5bz4A:
20.33
4qvqZ-5bz4A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 240
LEU A 234
GLY A 253
ALA A 252
SER A 255
 None
 0.97A 4rrwC-5bz4A:
undetectable		 4rrwC-5bz4A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 240
LEU A 234
GLY A 253
ALA A 252
SER A 255
 None
 1.00A 4rrwD-5bz4A:
undetectable		 4rrwD-5bz4A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 240
LEU A 234
GLY A 253
ALA A 252
SER A 255
 None
 1.04A 4rrxA-5bz4A:
undetectable		 4rrxA-5bz4A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 240
LEU A 234
GLY A 253
ALA A 252
SER A 255
 None
 1.05A 4rrxB-5bz4A:
undetectable		 4rrxB-5bz4A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 240
LEU A 234
GLY A 253
ALA A 252
SER A 255
 None
 0.97A 4rrzC-5bz4A:
undetectable		 4rrzC-5bz4A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 240
LEU A 234
GLY A 253
ALA A 252
SER A 255
 None
 1.00A 4rrzD-5bz4A:
undetectable		 4rrzD-5bz4A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 GLY A 396
ALA A 290
GLY A 300
PRO A 301
 None
 0.92A 4u9uA-5bz4A:
undetectable		 4u9uA-5bz4A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 GLY A 396
ALA A 290
GLY A 300
PRO A 301
 None
 0.95A 4u9uB-5bz4A:
undetectable		 4u9uB-5bz4A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 282
LEU A 316
LEU A 314
LEU A 386
ALA A 312
 None
 1.09A 4x1kA-5bz4A:
undetectable
4x1kB-5bz4A:
undetectable		 4x1kA-5bz4A:
22.72
4x1kB-5bz4A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 LEU A  31
ALA A  35
GLY A  56
HIS A  57
LEU A  55
 None
 1.16A 5dxbA-5bz4A:
undetectable		 5dxbA-5bz4A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 161
GLY A  93
GLY A 363
PHE A 328
THR A 150
 None
 1.06A 5eqbA-5bz4A:
undetectable		 5eqbA-5bz4A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  77
LEU A  55
ILE A 266
ALA A  35
LEU A  39
 None
 1.19A 5ienB-5bz4A:
undetectable		 5ienB-5bz4A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 THR A 128
SER A 127
TYR A 126
 None
 0.79A 5jsdA-5bz4A:
undetectable		 5jsdA-5bz4A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 THR A 128
SER A 127
TYR A 126
 None
 0.81A 5jsdB-5bz4A:
undetectable		 5jsdB-5bz4A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 THR A 128
SER A 127
TYR A 126
 None
 0.79A 5jsdC-5bz4A:
undetectable		 5jsdC-5bz4A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 THR A 128
SER A 127
TYR A 126
 None
 0.79A 5jseA-5bz4A:
undetectable		 5jseA-5bz4A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 THR A 128
SER A 127
TYR A 126
 None
 0.78A 5jseB-5bz4A:
undetectable		 5jseB-5bz4A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 THR A 128
SER A 127
TYR A 126
 None
 0.79A 5jseC-5bz4A:
undetectable		 5jseC-5bz4A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 LEU A 324
GLY A 298
GLY A 300
LEU A 333
LEU A 170
 None
 1.01A 5l0zB-5bz4A:
undetectable		 5l0zB-5bz4A:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 370
GLY A 366
GLU A 387
LEU A 386
GLU A 323
 None
 1.29A 5nwvA-5bz4A:
undetectable		 5nwvA-5bz4A:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5bz4 BETA-KETOTHIOLASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 LEU A 242
ASN A 254
LEU A 164
 None
 0.77A 6exiD-5bz4A:
undetectable		 6exiD-5bz4A:
13.46