SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bz6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 5bz6 LYSOZYME,CALCIUM
UNIPORTER PROTEIN,
MITOCHONDRIAL
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 7 LEU A1156
THR A 151
ASN A 101
TYR A 161
 None
 1.34A 1afsA-5bz6A:
undetectable		 1afsA-5bz6A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 5bz6 LYSOZYME,CALCIUM
UNIPORTER PROTEIN,
MITOCHONDRIAL
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 7 LEU A1156
THR A 151
ASN A 101
TYR A 161
 None
 1.34A 1afsB-5bz6A:
undetectable		 1afsB-5bz6A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5bz6 LYSOZYME,CALCIUM
UNIPORTER PROTEIN,
MITOCHONDRIAL
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 ALA A 129
PHE A 153
LEU A 133
ALA A 130
ILE A  78
 None
 0.97A 2aclA-5bz6A:
undetectable
2aclE-5bz6A:
undetectable		 2aclA-5bz6A:
24.82
2aclE-5bz6A:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5bz6 LYSOZYME,CALCIUM
UNIPORTER PROTEIN,
MITOCHONDRIAL
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 6 PHE A 153
VAL A  87
LEU A 118
ALA A 129
 None
 1.01A 2e1qA-5bz6A:
undetectable		 2e1qA-5bz6A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5bz6 LYSOZYME,CALCIUM
UNIPORTER PROTEIN,
MITOCHONDRIAL
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 6 PHE A 153
VAL A  87
LEU A 118
ALA A 129
 None
 1.00A 2e1qC-5bz6A:
undetectable		 2e1qC-5bz6A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5bz6 LYSOZYME,CALCIUM
UNIPORTER PROTEIN,
MITOCHONDRIAL
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 LEU A1115
LEU A1112
PHE A1111
ILE A1153
VAL A1160
 None
 1.09A 2pnjA-5bz6A:
undetectable		 2pnjA-5bz6A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 5bz6 LYSOZYME,CALCIUM
UNIPORTER PROTEIN,
MITOCHONDRIAL
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 LEU A1112
PHE A1149
ILE A1141
LEU A1145
THR A1157
 None
None
None
None
SO4  A2004 (-3.3A)
 1.16A 2w3bB-5bz6A:
undetectable		 2w3bB-5bz6A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5bz6 LYSOZYME,CALCIUM
UNIPORTER PROTEIN,
MITOCHONDRIAL
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 8 THR A  34
TYR A  25
ILE A  17
SER A  36
 None
 1.12A 2xytH-5bz6A:
undetectable		 2xytH-5bz6A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5bz6 LYSOZYME,CALCIUM
UNIPORTER PROTEIN,
MITOCHONDRIAL
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 11 ALA A 129
PHE A 153
LEU A 133
ALA A 130
ILE A  78
 None
 1.02A 3fc6A-5bz6A:
undetectable		 3fc6A-5bz6A:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5bz6 LYSOZYME,CALCIUM
UNIPORTER PROTEIN,
MITOCHONDRIAL
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 7 PHE A 153
VAL A  87
LEU A 118
ALA A 129
 None
 1.01A 3uniA-5bz6A:
undetectable		 3uniA-5bz6A:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5bz6 LYSOZYME,CALCIUM
UNIPORTER PROTEIN,
MITOCHONDRIAL
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 6 ASN A   2
GLU A  64
LEU A   7
PHE A  67
 None
 1.27A 4twdI-5bz6A:
undetectable
4twdJ-5bz6A:
undetectable		 4twdI-5bz6A:
24.32
4twdJ-5bz6A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5bz6 LYSOZYME,CALCIUM
UNIPORTER PROTEIN,
MITOCHONDRIAL
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 7 THR A  26
TYR A  18
GLU A  11
HIS A  31
 None
 1.02A 5ecnA-5bz6A:
undetectable		 5ecnA-5bz6A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 5bz6 LYSOZYME,CALCIUM
UNIPORTER PROTEIN,
MITOCHONDRIAL
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 MET A 102
ALA A  74
VAL A 149
LEU A 121
VAL A  87
 None
 1.27A 5tudD-5bz6A:
undetectable		 5tudD-5bz6A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5bz6 LYSOZYME,CALCIUM
UNIPORTER PROTEIN,
MITOCHONDRIAL
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 10 GLY A  30
GLY A  12
GLU A  11
ASP A  10
ASN A  20
 None
SO4  A2004 (-3.5A)
None
None
None
 1.23A 6exiA-5bz6A:
undetectable		 6exiA-5bz6A:
13.64