SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c00'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5c00 MDBA PROTEIN
(Corynebacterium
diphtheriae) 		4 / 7 ASP A 125
ASN A 122
PHE A 201
SER A  90
 None
 1.50A 1rqpB-5c00A:
undetectable		 1rqpB-5c00A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5c00 MDBA PROTEIN
(Corynebacterium
diphtheriae) 		5 / 8 ASP A 125
ASN A 122
PHE A 201
SER A  90
ALA A 205
 None
 1.42A 1rqpC-5c00A:
undetectable		 1rqpC-5c00A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5c00 MDBA PROTEIN
(Corynebacterium
diphtheriae) 		4 / 8 ASP A 125
ASN A 122
PHE A 201
ALA A 205
 None
 1.14A 1rqpA-5c00A:
undetectable		 1rqpA-5c00A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5c00 MDBA PROTEIN
(Corynebacterium
diphtheriae) 		4 / 8 GLN A 163
PHE A  89
ASN A 122
ASP A  88
 None
 1.31A 1zzuA-5c00A:
undetectable		 1zzuA-5c00A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 5c00 MDBA PROTEIN
(Corynebacterium
diphtheriae) 		4 / 8 GLN A 163
PHE A  89
ASN A 122
ASP A  88
 None
 1.29A 3n62A-5c00A:
undetectable		 3n62A-5c00A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5c00 MDBA PROTEIN
(Corynebacterium
diphtheriae) 		4 / 6 GLU A 150
ASN A 154
GLU A  87
VAL A 116
 None
 1.11A 4ejwB-5c00A:
undetectable		 4ejwB-5c00A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5c00 MDBA PROTEIN
(Corynebacterium
diphtheriae) 		4 / 8 ASP A  66
ASP A 215
ASN A 208
ASP A  84
 None
 1.16A 4fewD-5c00A:
undetectable		 4fewD-5c00A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5c00 MDBA PROTEIN
(Corynebacterium
diphtheriae) 		4 / 8 ASP A  66
ASP A 215
ASN A 208
ASP A  84
 None
 1.19A 4gkiA-5c00A:
undetectable		 4gkiA-5c00A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 5c00 MDBA PROTEIN
(Corynebacterium
diphtheriae) 		5 / 12 VAL A 239
ILE A 114
GLU A 110
ILE A 109
ALA A  73
 None
 1.09A 4ltwA-5c00A:
undetectable		 4ltwA-5c00A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 5c00 MDBA PROTEIN
(Corynebacterium
diphtheriae) 		5 / 12 VAL A 143
ALA A 142
GLY A 137
ASP A 148
THR A 151
 None
 1.37A 4mm4A-5c00A:
undetectable		 4mm4A-5c00A:
15.77