SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c08'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 5c08 1E6 TCR ALPHA CHAIN
1E6 TCR BETA CHAIN
(Homo
sapiens) 		4 / 8 ASP D 138
ASP D 117
TYR D 121
THR E 140
 None
 1.28A 1ceaA-5c08D:
undetectable
1ceaB-5c08D:
undetectable		 1ceaA-5c08D:
23.57
1ceaB-5c08D:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 5c08 1E6 TCR ALPHA CHAIN
(Homo
sapiens) 		3 / 3 ALA D 183
VAL D 133
TRP D 176
 None
 0.78A 1gmkA-5c08D:
undetectable
1gmkB-5c08D:
undetectable		 1gmkA-5c08D:
5.75
1gmkB-5c08D:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 5c08 1E6 TCR ALPHA CHAIN
(Homo
sapiens) 		3 / 3 ALA D 183
VAL D 133
TRP D 176
 None
 0.87A 1gmkC-5c08D:
undetectable
1gmkD-5c08D:
undetectable		 1gmkC-5c08D:
5.75
1gmkD-5c08D:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5c08 1E6 TCR BETA CHAIN
(Homo
sapiens) 		4 / 6 GLU E  11
ARG E  64
LEU E 113
ASP E  86
 None
 0.97A 1mt1B-5c08E:
undetectable
1mt1C-5c08E:
undetectable		 1mt1B-5c08E:
17.96
1mt1C-5c08E:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 5c08 1E6 TCR ALPHA CHAIN
1E6 TCR BETA CHAIN
(Homo
sapiens) 		4 / 6 THR D 156
ASP E 175
PRO E 178
VAL E 157
 None
 1.30A 2hdnI-5c08D:
undetectable
2hdnJ-5c08D:
undetectable
2hdnL-5c08D:
undetectable		 2hdnI-5c08D:
10.27
2hdnJ-5c08D:
17.78
2hdnL-5c08D:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5c08 1E6 TCR BETA CHAIN
(Homo
sapiens) 		4 / 8 GLY E 218
VAL E 122
LEU E 116
PRO E 154
 None
 1.10A 3bgdB-5c08E:
undetectable		 3bgdB-5c08E:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 5c08 1E6 TCR ALPHA CHAIN
1E6 TCR BETA CHAIN
(Homo
sapiens) 		4 / 7 GLN E  37
GLU D   5
ARG E  41
PRO D   8
 None
 1.32A 3ql6A-5c08E:
undetectable		 3ql6A-5c08E:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4A_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5c08 1E6 TCR BETA CHAIN
(Homo
sapiens) 		4 / 8 THR E 111
THR E  13
LEU E  21
VAL E  19
 None
 0.95A 4l4aA-5c08E:
undetectable		 4l4aA-5c08E:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5c08 1E6 TCR BETA CHAIN
(Homo
sapiens) 		4 / 8 THR E 111
THR E  13
LEU E  21
VAL E  19
 None
 0.92A 4l4dA-5c08E:
undetectable		 4l4dA-5c08E:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5c08 1E6 TCR BETA CHAIN
(Homo
sapiens) 		4 / 8 THR E 111
THR E  13
LEU E  21
VAL E  19
 None
 0.95A 4l4eA-5c08E:
undetectable		 4l4eA-5c08E:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5c08 1E6 TCR BETA CHAIN
(Homo
sapiens) 		4 / 8 THR E 111
THR E  13
LEU E  21
VAL E  19
 None
 0.95A 4l4fA-5c08E:
undetectable		 4l4fA-5c08E:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 5c08 1E6 TCR BETA CHAIN
(Homo
sapiens) 		5 / 12 ASN E  50
MET E  69
ASN E  52
GLY E  28
ASP E  30
 GOL  E 306 (-3.5A)
None
None
None
GOL  E 306 (-2.7A)
 1.30A 4qckA-5c08E:
undetectable		 4qckA-5c08E:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 5c08 1E6 TCR ALPHA CHAIN
1E6 TCR BETA CHAIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ARG E 195
THR D 156
ASP E 175
 None
 0.96A 5g5gA-5c08E:
undetectable
5g5gB-5c08E:
undetectable		 5g5gA-5c08E:
22.39
5g5gB-5c08E:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 5c08 1E6 TCR BETA CHAIN
(Homo
sapiens) 		4 / 8 THR E  38
TYR E  90
PHE E  65
PRO E  61
 None
 1.21A 5v4vA-5c08E:
undetectable		 5v4vA-5c08E:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 5c08 1E6 TCR BETA CHAIN
(Homo
sapiens) 		4 / 8 THR E  38
TYR E  90
PHE E  65
PRO E  61
 None
 1.20A 5v4vB-5c08E:
undetectable		 5v4vB-5c08E:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 5c08 1E6 TCR ALPHA CHAIN
(Homo
sapiens) 		4 / 6 GLN D   6
MET D  48
ASN D  22
LEU D  47
 None
None
SO4  D 204 (-4.0A)
None
 1.20A 5xdhA-5c08D:
undetectable
5xdhC-5c08D:
undetectable		 5xdhA-5c08D:
20.75
5xdhC-5c08D:
20.75