SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c0p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 5c0p ENDO-ARABINASE
(Bacteroides
thetaiotaomicron) 		4 / 6 TRP A 157
LEU A 207
ARG A 178
GLY A 186
 None
 1.18A 2hs2B-5c0pA:
undetectable		 2hs2B-5c0pA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 5c0p ENDO-ARABINASE
(Bacteroides
thetaiotaomicron) 		4 / 7 GLY A 162
ILE A 188
THR A 229
LEU A 160
 None
None
None
TRS  A 409 ( 3.8A)
 0.95A 2xrhA-5c0pA:
undetectable		 2xrhA-5c0pA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 5c0p ENDO-ARABINASE
(Bacteroides
thetaiotaomicron) 		4 / 5 ILE A 313
PRO A 315
VAL A 268
PHE A 323
 None
None
GOL  A 405 (-3.8A)
None
 1.18A 2ygnA-5c0pA:
undetectable		 2ygnA-5c0pA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z71_A_PNVA903_1
(PENICILLIN ACYLASE)		 5c0p ENDO-ARABINASE
(Bacteroides
thetaiotaomicron) 		5 / 10 THR A 229
ASN A 305
ARG A  52
ASP A 230
GLY A 285
 None
None
TRS  A 409 (-4.3A)
TRS  A 409 (-3.3A)
None
 1.14A 2z71A-5c0pA:
undetectable
2z71C-5c0pA:
undetectable		 2z71A-5c0pA:
20.85
2z71C-5c0pA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 5c0p ENDO-ARABINASE
(Bacteroides
thetaiotaomicron) 		3 / 3 GLU A 179
ASP A 230
ASP A 104
 None
TRS  A 409 (-3.3A)
None
 0.76A 3jb2A-5c0pA:
undetectable		 3jb2A-5c0pA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 5c0p ENDO-ARABINASE
(Bacteroides
thetaiotaomicron) 		4 / 8 HIS A 286
TRP A  86
SER A 300
ILE A  56
 MG  A 402 ( 3.4A)
None
None
None
 0.85A 3sfeB-5c0pA:
undetectable
3sfeC-5c0pA:
undetectable		 3sfeB-5c0pA:
22.15
3sfeC-5c0pA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 5c0p ENDO-ARABINASE
(Bacteroides
thetaiotaomicron) 		4 / 7 GLU A 179
ASP A 230
ILE A 219
TRP A 180
 None
TRS  A 409 (-3.3A)
None
None
 1.07A 4ii8A-5c0pA:
undetectable		 4ii8A-5c0pA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 5c0p ENDO-ARABINASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ALA A 261
TRP A 272
VAL A 273
 None
 0.33A 4w9nC-5c0pA:
undetectable		 4w9nC-5c0pA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 5c0p ENDO-ARABINASE
(Bacteroides
thetaiotaomicron) 		4 / 8 ASP A 161
TYR A 256
ASP A 230
ILE A 219
 TRS  A 409 (-2.8A)
None
TRS  A 409 (-3.3A)
None
 0.94A 4xjeA-5c0pA:
undetectable		 4xjeA-5c0pA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 5c0p ENDO-ARABINASE
(Bacteroides
thetaiotaomicron) 		4 / 8 ASP A 161
TYR A 256
ASP A 230
ILE A 219
 TRS  A 409 (-2.8A)
None
TRS  A 409 (-3.3A)
None
 0.97A 5cfsA-5c0pA:
undetectable		 5cfsA-5c0pA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_0
(REGULATORY PROTEIN
TETR)		 5c0p ENDO-ARABINASE
(Bacteroides
thetaiotaomicron) 		5 / 12 MET A 244
ALA A 261
GLU A 277
LEU A 279
VAL A 216
 None
None
None
GOL  A 408 ( 4.6A)
None
 1.42A 5vlmC-5c0pA:
undetectable		 5vlmC-5c0pA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 5c0p ENDO-ARABINASE
(Bacteroides
thetaiotaomicron) 		5 / 12 HIS A 302
GLY A 217
VAL A 216
GLY A 284
GLY A 285
 None
 1.13A 6brdB-5c0pA:
undetectable		 6brdB-5c0pA:
13.78