SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c0u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5c0u ALKYLMERCURY LYASE
(Escherichia
coli) 		5 / 9 VAL A 189
VAL A 113
LEU A 126
ALA A  97
LEU A 101
 None
 0.90A 1eqgA-5c0uA:
undetectable		 1eqgA-5c0uA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5c0u ALKYLMERCURY LYASE
(Escherichia
coli) 		5 / 11 VAL A 189
VAL A 113
LEU A 126
ALA A  97
LEU A 101
 None
 0.90A 1eqgB-5c0uA:
undetectable		 1eqgB-5c0uA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5c0u ALKYLMERCURY LYASE
(Escherichia
coli) 		5 / 12 VAL A 189
VAL A 113
LEU A 126
ALA A  97
LEU A 101
 None
 0.89A 1eqhA-5c0uA:
undetectable		 1eqhA-5c0uA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5c0u ALKYLMERCURY LYASE
(Escherichia
coli) 		5 / 12 VAL A 189
VAL A 113
LEU A 126
ALA A  97
LEU A 101
 None
 0.90A 1eqhB-5c0uA:
undetectable		 1eqhB-5c0uA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5c0u ALKYLMERCURY LYASE
(Escherichia
coli) 		4 / 7 VAL A 189
VAL A 113
ALA A  97
LEU A 101
 None
 0.73A 1pthA-5c0uA:
undetectable		 1pthA-5c0uA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5c0u ALKYLMERCURY LYASE
(Escherichia
coli) 		4 / 7 VAL A 189
VAL A 113
ALA A  97
LEU A 101
 None
 0.74A 1pthB-5c0uA:
undetectable		 1pthB-5c0uA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5c0u ALKYLMERCURY LYASE
(Escherichia
coli) 		4 / 7 PHE A 165
ALA A 171
ALA A 175
LEU A 181
 None
 0.86A 2wx2A-5c0uA:
undetectable		 2wx2A-5c0uA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5c0u ALKYLMERCURY LYASE
(Escherichia
coli) 		4 / 8 PHE A 165
ALA A 171
ALA A 175
LEU A 181
 None
 0.76A 2wx2B-5c0uA:
undetectable		 2wx2B-5c0uA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 5c0u ALKYLMERCURY LYASE
(Escherichia
coli) 		4 / 8 TYR A  83
VAL A  84
SER A 144
TYR A  93
 None
 1.14A 2y05A-5c0uA:
undetectable
2y05B-5c0uA:
undetectable		 2y05A-5c0uA:
21.49
2y05B-5c0uA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5c0u ALKYLMERCURY LYASE
(Escherichia
coli) 		5 / 12 LEU A  28
VAL A  14
ILE A 102
PHE A 199
THR A  20
 None
 1.13A 3fl9G-5c0uA:
undetectable		 3fl9G-5c0uA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 5c0u ALKYLMERCURY LYASE
(Escherichia
coli) 		5 / 11 LEU A  28
VAL A  14
ASN A 200
PHE A 199
THR A  20
 None
 1.19A 3jw5A-5c0uA:
undetectable		 3jw5A-5c0uA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 5c0u ALKYLMERCURY LYASE
(Escherichia
coli) 		4 / 8 PHE A 165
ALA A 171
ALA A 175
LEU A 181
 None
 0.82A 3khmA-5c0uA:
undetectable		 3khmA-5c0uA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5c0u ALKYLMERCURY LYASE
(Escherichia
coli) 		5 / 12 VAL A 189
VAL A 113
LEU A 126
ALA A  97
LEU A 101
 None
 0.96A 3n8wA-5c0uA:
undetectable		 3n8wA-5c0uA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5c0u ALKYLMERCURY LYASE
(Escherichia
coli) 		5 / 12 VAL A 189
VAL A 113
LEU A 126
ALA A  97
LEU A 101
 None
 0.96A 3n8zA-5c0uA:
undetectable		 3n8zA-5c0uA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 5c0u ALKYLMERCURY LYASE
(Escherichia
coli) 		5 / 12 VAL A 189
VAL A 113
LEU A 126
ALA A  97
LEU A 101
 None
 0.80A 3pghA-5c0uA:
undetectable		 3pghA-5c0uA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5c0u ALKYLMERCURY LYASE
(Escherichia
coli) 		5 / 12 VAL A 189
VAL A 113
LEU A 126
ALA A  97
LEU A 101
 None
 0.84A 3rr3A-5c0uA:
undetectable		 3rr3A-5c0uA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5c0u ALKYLMERCURY LYASE
(Escherichia
coli) 		5 / 12 VAL A 189
VAL A 113
LEU A 126
ALA A  97
LEU A 101
 None
 0.84A 3rr3B-5c0uA:
undetectable		 3rr3B-5c0uA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 5c0u ALKYLMERCURY LYASE
(Escherichia
coli) 		5 / 12 LEU A  10
VAL A  14
THR A  63
ILE A  71
LEU A  28
 None
 1.21A 3sp9B-5c0uA:
undetectable		 3sp9B-5c0uA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 5c0u ALKYLMERCURY LYASE
(Escherichia
coli) 		4 / 7 ALA A 192
ALA A  97
LEU A 101
THR A 100
 None
 0.88A 4du2B-5c0uA:
undetectable		 4du2B-5c0uA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 5c0u ALKYLMERCURY LYASE
(Escherichia
coli) 		5 / 10 LEU A 195
GLY A 196
PHE A 199
ASN A 200
LYS A   1
 None
 1.48A 4eb4D-5c0uA:
undetectable		 4eb4D-5c0uA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 5c0u ALKYLMERCURY LYASE
(Escherichia
coli) 		5 / 9 PHE A 193
GLN A 134
LEU A 126
VAL A 113
LEU A 101
 None
 1.25A 4g1bC-5c0uA:
undetectable		 4g1bC-5c0uA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5c0u ALKYLMERCURY LYASE
(Escherichia
coli) 		5 / 10 VAL A 189
VAL A 113
LEU A 126
ALA A  97
LEU A 101
 None
 0.89A 4ph9A-5c0uA:
undetectable		 4ph9A-5c0uA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5c0u ALKYLMERCURY LYASE
(Escherichia
coli) 		5 / 10 VAL A 189
VAL A 113
LEU A 126
ALA A  97
LEU A 101
 None
 0.89A 4ph9B-5c0uA:
undetectable		 4ph9B-5c0uA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 5c0u ALKYLMERCURY LYASE
(Escherichia
coli) 		5 / 12 HIS A 163
LEU A 184
PHE A 165
HIS A 178
LEU A 181
 None
 1.39A 4r88A-5c0uA:
undetectable		 4r88A-5c0uA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 5c0u ALKYLMERCURY LYASE
(Escherichia
coli) 		5 / 10 ILE A  45
LEU A  46
VAL A  56
ILE A  71
LEU A  57
 None
 1.15A 5ienB-5c0uA:
undetectable		 5ienB-5c0uA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 5c0u ALKYLMERCURY LYASE
(Escherichia
coli) 		5 / 12 LEU A  28
LEU A  31
ALA A  32
LEU A  92
ILE A 102
 None
 1.05A 5toaA-5c0uA:
undetectable		 5toaA-5c0uA:
22.26