SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c0y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5c0y EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 501
ALA A 453
VAL A 483
MET A 464
LEU A 468
 None
 1.43A 1kt6A-5c0yA:
undetectable		 1kt6A-5c0yA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5c0y EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 501
ALA A 453
VAL A 483
MET A 464
LEU A 468
 None
 1.45A 1kt7A-5c0yA:
undetectable		 1kt7A-5c0yA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 5c0y EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 148
TYR A 307
PRO A 150
 None
 1.09A 1mcnA-5c0yA:
undetectable
1mcnB-5c0yA:
undetectable
1mcnP-5c0yA:
undetectable		 1mcnA-5c0yA:
20.00
1mcnB-5c0yA:
20.00
1mcnP-5c0yA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 5c0y EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 486
PRO A 435
ILE A 505
LEU A 472
 None
 1.04A 1ya4B-5c0yA:
undetectable		 1ya4B-5c0yA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 5c0y EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 297
LEU A 300
ASP A 238
ALA A 293
 None
 0.96A 2opxA-5c0yA:
undetectable		 2opxA-5c0yA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5c0y EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 192
GLU A 186
TYR A 185
 None
 0.96A 3ug8A-5c0yA:
undetectable		 3ug8A-5c0yA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5c0y EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		4 / 8 SER A 383
ILE A 196
VAL A 287
PHE A 312
 None
 0.95A 4dx7B-5c0yA:
undetectable		 4dx7B-5c0yA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 5c0y EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 316
VAL A 389
GLU A 392
VAL A 396
 None
 1.42A 4p6vB-5c0yA:
undetectable
4p6vE-5c0yA:
undetectable		 4p6vB-5c0yA:
21.05
4p6vE-5c0yA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5c0y EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		4 / 5 SER A 327
ALA A 329
GLN A 345
THR A 340
 None
 1.36A 5n0wB-5c0yA:
undetectable		 5n0wB-5c0yA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5c0y EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		4 / 4 SER A 327
ALA A 329
GLN A 345
THR A 340
 None
 1.38A 5n0xA-5c0yA:
undetectable		 5n0xA-5c0yA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5c0y EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		4 / 5 SER A 327
ALA A 329
GLN A 345
THR A 340
 None
 1.32A 5n4iA-5c0yA:
undetectable		 5n4iA-5c0yA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGP_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5c0y EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		4 / 4 VAL A 216
VAL A 265
TYR A 263
GLN A 255
 None
 1.47A 5qgpA-5c0yA:
undetectable		 5qgpA-5c0yA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGQ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5c0y EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		4 / 4 VAL A 216
VAL A 265
TYR A 263
GLN A 255
 None
 1.47A 5qgqA-5c0yA:
undetectable		 5qgqA-5c0yA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 5c0y EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 493
ARG A 455
ILE A 452
 None
 0.66A 6fgdA-5c0yA:
undetectable		 6fgdA-5c0yA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5c0y EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		4 / 8 HIS A 291
HIS A 367
ASP A 238
GLU A 240
 None
 1.22A 6mn4B-5c0yA:
undetectable		 6mn4B-5c0yA:
21.53