SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c12'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 5c12 GENE 2 PROTEIN
(Shigella
virus
Sf6) 		3 / 3 SER A 241
TYR A 293
HIS A 292
 None
 0.56A 2r2vD-5c12A:
undetectable		 2r2vD-5c12A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 5c12 GENE 2 PROTEIN
(Shigella
virus
Sf6) 		4 / 6 LEU A 410
MET A 450
LEU A 391
VAL A 379
 None
 1.03A 4okbA-5c12A:
undetectable		 4okbA-5c12A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5c12 GENE 2 PROTEIN
(Shigella
virus
Sf6) 		6 / 9 LEU A 221
LEU A 406
LEU A 446
LEU A 368
LEU A 372
ALA A 224
 None
 1.23A 4z91F-5c12A:
undetectable
4z91G-5c12A:
undetectable
4z91H-5c12A:
undetectable
4z91I-5c12A:
undetectable
4z91J-5c12A:
undetectable		 4z91F-5c12A:
20.75
4z91G-5c12A:
20.75
4z91H-5c12A:
20.75
4z91I-5c12A:
20.75
4z91J-5c12A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 5c12 GENE 2 PROTEIN
(Shigella
virus
Sf6) 		5 / 12 ASP A 247
ALA A 445
THR A 282
GLN A 307
GLY A 301
 MG  A 801 (-4.1A)
None
None
None
None
 1.26A 5m54E-5c12A:
undetectable		 5m54E-5c12A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5c12 GENE 2 PROTEIN
(Shigella
virus
Sf6) 		5 / 12 VAL A 379
LEU A 403
ALA A 227
ARG A 218
ARG A 377
 None
 1.43A 5syfB-5c12A:
undetectable		 5syfB-5c12A:
21.82