SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c17'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 5c17 MERB2
(Bacillus
megaterium) 		5 / 11 ALA A 115
LEU A  93
ARG A  96
LEU A 113
ILE A  33
 None
 1.06A 1ha2A-5c17A:
undetectable		 1ha2A-5c17A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5c17 MERB2
(Bacillus
megaterium) 		5 / 12 SER A  42
THR A  40
VAL A  39
LEU A  26
ILE A  25
 None
 1.34A 2fj1A-5c17A:
2.1		 2fj1A-5c17A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5c17 MERB2
(Bacillus
megaterium) 		5 / 12 ILE A 130
ILE A 104
THR A 106
VAL A 152
HIS A 169
 None
DTV  A 303 ( 3.0A)
None
None
GOL  A 302 (-3.0A)
 1.12A 2qo5A-5c17A:
undetectable		 2qo5A-5c17A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 5c17 MERB2
(Bacillus
megaterium) 		3 / 3 LEU A  98
ARG A  34
ILE A  91
 None
 0.59A 2xn5B-5c17A:
undetectable		 2xn5B-5c17A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5c17 MERB2
(Bacillus
megaterium) 		4 / 5 ARG A  65
PHE A 154
PHE A  10
LEU A  14
 None
DTV  A 303 (-3.0A)
DTV  A 303 ( 3.8A)
None
 1.33A 2y69C-5c17A:
undetectable
2y69J-5c17A:
undetectable		 2y69C-5c17A:
21.82
2y69J-5c17A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5c17 MERB2
(Bacillus
megaterium) 		4 / 5 ARG A  65
PHE A 154
PHE A  10
LEU A  14
 None
DTV  A 303 (-3.0A)
DTV  A 303 ( 3.8A)
None
 1.35A 2y69P-5c17A:
undetectable
2y69W-5c17A:
undetectable		 2y69P-5c17A:
21.82
2y69W-5c17A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5c17 MERB2
(Bacillus
megaterium) 		4 / 5 ARG A  65
PHE A 154
PHE A  10
LEU A  14
 None
DTV  A 303 (-3.0A)
DTV  A 303 ( 3.8A)
None
 1.31A 3abmC-5c17A:
undetectable
3abmJ-5c17A:
undetectable		 3abmC-5c17A:
21.82
3abmJ-5c17A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 5c17 MERB2
(Bacillus
megaterium) 		5 / 10 ILE A  29
ALA A  79
TYR A  11
LEU A 204
ILE A 168
 None
None
None
None
DTV  A 303 ( 4.9A)
 1.24A 3prsA-5c17A:
undetectable		 3prsA-5c17A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 5c17 MERB2
(Bacillus
megaterium) 		4 / 7 ALA A 197
ALA A 103
LEU A 107
THR A 106
 None
 0.85A 4du2A-5c17A:
undetectable		 4du2A-5c17A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 5c17 MERB2
(Bacillus
megaterium) 		4 / 7 ALA A 197
ALA A 103
LEU A 107
THR A 106
 None
 0.82A 4du2B-5c17A:
undetectable		 4du2B-5c17A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 5c17 MERB2
(Bacillus
megaterium) 		4 / 5 GLU A 128
SER A 173
PRO A 144
SER A 146
 None
 0.98A 4k17B-5c17A:
undetectable		 4k17B-5c17A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5c17 MERB2
(Bacillus
megaterium) 		3 / 3 HIS A 184
GLU A 183
TRP A 180
 None
 0.83A 5odiD-5c17A:
undetectable		 5odiD-5c17A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5c17 MERB2
(Bacillus
megaterium) 		3 / 3 HIS A 184
GLU A 183
TRP A 180
 None
 0.80A 5odqD-5c17A:
undetectable		 5odqD-5c17A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5c17 MERB2
(Bacillus
megaterium) 		3 / 3 HIS A 184
GLU A 183
TRP A 180
 None
 0.76A 5odrD-5c17A:
undetectable		 5odrD-5c17A:
20.00