SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c1b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		5 / 12 ILE A 656
ALA A 685
ILE A 645
LEU A 482
THR A 688
 AGS  A 902 (-4.0A)
AGS  A 902 (-3.5A)
None
AGS  A 902 ( 4.7A)
AGS  A 902 (-3.1A)
 1.12A 1ddsB-5c1bA:
undetectable		 1ddsB-5c1bA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		5 / 12 ILE A 731
VAL A 670
LEU A 672
ALA A 739
ILE A 690
 None
 1.03A 1epbB-5c1bA:
undetectable		 1epbB-5c1bA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		4 / 8 PRO A 238
LEU A 222
PHE A 230
ARG A 365
 None
 0.84A 1h4oG-5c1bA:
undetectable		 1h4oG-5c1bA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		6 / 12 ILE A 656
ALA A 685
LEU A 526
ILE A 645
LEU A 482
THR A 688
 AGS  A 902 (-4.0A)
AGS  A 902 (-3.5A)
AGS  A 902 (-3.9A)
None
AGS  A 902 ( 4.7A)
AGS  A 902 (-3.1A)
 1.43A 1jolB-5c1bA:
undetectable		 1jolB-5c1bA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B0Q_A_NMYA305_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		5 / 12 GLU A  80
GLU A 221
GLU A 218
ASP A  29
SER A  78
 None
 1.35A 2b0qA-5c1bA:
undetectable		 2b0qA-5c1bA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		3 / 3 LYS A 524
ASP A 627
ASN A 624
 AGS  A 902 (-3.0A)
None
AGS  A 902 (-2.7A)
 0.92A 2bm9A-5c1bA:
2.5		 2bm9A-5c1bA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		5 / 12 LEU A 634
ILE A 604
LEU A 605
ILE A 601
ALA A 583
 None
None
None
CL  A 905 (-4.6A)
CL  A 905 ( 4.1A)
 0.70A 2gj5A-5c1bA:
undetectable		 2gj5A-5c1bA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		5 / 12 VAL A 343
ILE A 303
GLU A 292
ILE A 269
ILE A 274
 None
 1.16A 2gj5A-5c1bA:
undetectable		 2gj5A-5c1bA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		3 / 3 ASP A  98
ARG A  89
ARG A  95
 None
 1.01A 2j9dA-5c1bA:
undetectable
2j9dC-5c1bA:
undetectable		 2j9dA-5c1bA:
10.36
2j9dC-5c1bA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		5 / 9 LEU A 357
ILE A 303
GLU A 291
GLY A 334
LEU A 335
 None
 1.04A 2v0mB-5c1bA:
undetectable		 2v0mB-5c1bA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		3 / 3 ARG A  95
ASP A 204
ASN A  90
 None
 0.67A 2zzmA-5c1bA:
undetectable		 2zzmA-5c1bA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		5 / 10 GLU A 273
ILE A 269
LEU A 357
ILE A 309
MET A 332
 None
 1.04A 3adsA-5c1bA:
undetectable		 3adsA-5c1bA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		5 / 10 GLY A 594
ASP A 598
ILE A 601
VAL A 600
LEU A 548
 None
None
CL  A 905 (-4.6A)
None
None
 1.20A 3ay0B-5c1bA:
undetectable		 3ay0B-5c1bA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		5 / 12 LEU A 242
ALA A 310
ALA A 345
VAL A 343
PHE A 290
 None
 1.27A 3b0wA-5c1bA:
undetectable		 3b0wA-5c1bA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		5 / 12 LEU A 242
ALA A 310
ALA A 345
VAL A 343
PHE A 290
 None
 1.26A 3b0wB-5c1bA:
undetectable		 3b0wB-5c1bA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		5 / 10 ILE A 269
ILE A 274
GLY A 280
LEU A 331
ARG A 287
 None
 1.38A 3elzB-5c1bA:
undetectable		 3elzB-5c1bA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		5 / 11 ALA A 685
LEU A 526
ILE A 645
LEU A 482
THR A 688
 AGS  A 902 (-3.5A)
AGS  A 902 (-3.9A)
None
AGS  A 902 ( 4.7A)
AGS  A 902 (-3.1A)
 1.27A 3fl9C-5c1bA:
undetectable		 3fl9C-5c1bA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		4 / 8 THR A 623
GLY A 621
LEU A 639
ILE A 633
 None
 0.68A 3nbqB-5c1bA:
undetectable		 3nbqB-5c1bA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		4 / 8 THR A 623
GLY A 621
LEU A 639
ILE A 633
 None
 0.59A 3nbqC-5c1bA:
undetectable		 3nbqC-5c1bA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		5 / 12 ILE A 100
ALA A  67
LEU A  59
VAL A  57
LEU A  72
 None
 1.04A 3ozuA-5c1bA:
2.4		 3ozuA-5c1bA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		5 / 12 ALA A 622
LEU A 639
ILE A 601
PHE A 563
MET A 608
 None
None
CL  A 905 (-4.6A)
None
None
 1.46A 3qt0A-5c1bA:
undetectable		 3qt0A-5c1bA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		3 / 3 GLU A  80
ASP A  79
ASP A  29
 None
 0.76A 4gc9A-5c1bA:
undetectable		 4gc9A-5c1bA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		5 / 11 ILE A 216
ILE A 254
ALA A 346
ALA A 345
VAL A 258
 None
 1.18A 4h1nA-5c1bA:
undetectable		 4h1nA-5c1bA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		5 / 12 LEU A 579
GLN A 603
ILE A 604
ILE A 633
ALA A 632
 None
 1.02A 4ltwA-5c1bA:
undetectable		 4ltwA-5c1bA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		4 / 6 ASN A  90
GLU A 196
GLU A 195
GLU A 162
 None
 1.34A 4mi4A-5c1bA:
undetectable		 4mi4A-5c1bA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		5 / 12 ILE A 656
ALA A 685
ILE A 645
LEU A 482
THR A 688
 AGS  A 902 (-4.0A)
AGS  A 902 (-3.5A)
None
AGS  A 902 ( 4.7A)
AGS  A 902 (-3.1A)
 1.13A 4x5hA-5c1bA:
undetectable		 4x5hA-5c1bA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		5 / 12 LEU A 306
ILE A 303
GLU A 292
ILE A 269
ILE A 274
 None
 0.94A 4y0rA-5c1bA:
undetectable		 4y0rA-5c1bA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSH_B_ACTB401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		4 / 5 ARG A 155
LEU A 198
ASN A  85
VAL A  87
 None
 1.46A 5cshB-5c1bA:
undetectable		 5cshB-5c1bA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		5 / 12 ILE A 656
ALA A 685
ILE A 645
LEU A 482
THR A 688
 AGS  A 902 (-4.0A)
AGS  A 902 (-3.5A)
None
AGS  A 902 ( 4.7A)
AGS  A 902 (-3.1A)
 1.13A 5e8qB-5c1bA:
undetectable		 5e8qB-5c1bA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		5 / 12 ILE A 656
ALA A 685
ILE A 645
LEU A 482
THR A 688
 AGS  A 902 (-4.0A)
AGS  A 902 (-3.5A)
None
AGS  A 902 ( 4.7A)
AGS  A 902 (-3.1A)
 1.15A 5hi6B-5c1bA:
undetectable		 5hi6B-5c1bA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		5 / 12 ILE A 371
GLY A 370
HIS A 404
SER A 541
ILE A 540
 None
 1.22A 5igvA-5c1bA:
undetectable		 5igvA-5c1bA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		5 / 12 ILE A 371
GLY A 370
HIS A 404
SER A 541
ILE A 540
 None
 1.27A 5igwA-5c1bA:
undetectable		 5igwA-5c1bA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		5 / 12 ILE A 371
HIS A 404
ALA A 374
SER A 541
ILE A 540
 None
 1.44A 5iwuA-5c1bA:
undetectable		 5iwuA-5c1bA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		4 / 6 GLY A  97
ASP A 204
ILE A  32
ARG A  83
 None
 1.13A 5iwuA-5c1bA:
undetectable		 5iwuA-5c1bA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		3 / 3 LYS A 486
ASP A 484
ILE A 620
 None
 0.91A 5kc4E-5c1bA:
undetectable		 5kc4E-5c1bA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		4 / 8 VAL A 367
LEU A 243
VAL A 220
MET A 219
 None
 0.78A 5nujA-5c1bA:
undetectable		 5nujA-5c1bA:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_B_ACTB401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		4 / 5 ARG A 155
LEU A 198
ASN A  85
VAL A  87
 None
 1.46A 5os7B-5c1bA:
undetectable		 5os7B-5c1bA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		5 / 12 ILE A 656
ALA A 685
ILE A 645
LEU A 482
THR A 688
 AGS  A 902 (-4.0A)
AGS  A 902 (-3.5A)
None
AGS  A 902 ( 4.7A)
AGS  A 902 (-3.1A)
 1.12A 5ujxB-5c1bA:
undetectable		 5ujxB-5c1bA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_A_ACTA401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		4 / 5 ARG A 155
LEU A 198
ASN A  85
VAL A  87
 None
 1.46A 6gmdA-5c1bA:
undetectable		 6gmdA-5c1bA:
18.39