SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c1i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI
(Thermus
thermophilus) 		5 / 10 LEU A 191
ALA A 248
LEU A  88
MET A  85
LEU A  89
 None
 1.43A 1pcgB-5c1iA:
undetectable		 1pcgB-5c1iA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI
(Thermus
thermophilus) 		4 / 7 LEU A 183
TYR A 164
ALA A 157
LEU A 154
 None
 0.84A 1pthA-5c1iA:
undetectable		 1pthA-5c1iA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI
(Thermus
thermophilus) 		4 / 7 LEU A 183
TYR A 164
ALA A 157
LEU A 154
 None
 0.84A 1pthB-5c1iA:
undetectable		 1pthB-5c1iA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKT_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI
(Thermus
thermophilus) 		5 / 10 LEU A 191
ALA A 248
LEU A  88
MET A  85
LEU A  89
 None
 1.39A 1qktA-5c1iA:
undetectable		 1qktA-5c1iA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI
(Thermus
thermophilus) 		5 / 12 GLY A 103
SER A 104
GLY A 106
ARG A 127
HIS A 130
 None
 1.13A 2b25B-5c1iA:
27.0		 2b25B-5c1iA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI
(Thermus
thermophilus) 		5 / 12 THR A  77
GLY A 103
SER A 104
GLY A 106
HIS A 130
 None
 0.97A 2b25B-5c1iA:
27.0		 2b25B-5c1iA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI
(Thermus
thermophilus) 		5 / 10 ALA A 168
ALA A 181
ARG A 251
LEU A 178
LEU A  89
 None
 1.14A 2bxqA-5c1iA:
undetectable		 2bxqA-5c1iA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI
(Thermus
thermophilus) 		5 / 11 ALA A 208
LEU A 169
LEU A 178
LEU A 191
ARG A 251
 None
 1.04A 2ceoA-5c1iA:
undetectable		 2ceoA-5c1iA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI
(Thermus
thermophilus) 		4 / 8 VAL A 247
VAL A 201
LEU A 246
HIS A 242
 None
 1.06A 2ddwA-5c1iA:
2.9		 2ddwA-5c1iA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI
(Thermus
thermophilus) 		5 / 10 ALA A 208
LEU A 169
LEU A 178
LEU A 191
ARG A 251
 None
 1.14A 2riwA-5c1iA:
undetectable
2riwB-5c1iA:
undetectable		 2riwA-5c1iA:
22.38
2riwB-5c1iA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI
(Thermus
thermophilus) 		4 / 7 GLY A 101
GLY A 103
GLU A 125
ALA A 170
 None
 0.87A 3fpjB-5c1iA:
15.1		 3fpjB-5c1iA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI
(Thermus
thermophilus) 		4 / 6 MET A  85
LEU A 246
PRO A 196
GLN A 200
 None
 1.18A 3vkxA-5c1iA:
undetectable		 3vkxA-5c1iA:
22.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI
(Thermus
thermophilus) 		6 / 12 GLY A 101
GLY A 106
LEU A 107
ALA A 126
GLU A 155
LEU A 171
 None
 0.71A 5c0oE-5c1iA:
33.1		 5c0oE-5c1iA:
98.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI
(Thermus
thermophilus) 		5 / 12 GLY A 101
GLY A 106
LEU A 107
ALA A 126
HIS A 130
 None
 0.55A 5c0oE-5c1iA:
33.1		 5c0oE-5c1iA:
98.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI
(Thermus
thermophilus) 		5 / 12 GLY A 103
GLY A 106
LEU A 107
ALA A 126
HIS A 130
 None
 0.72A 5c0oE-5c1iA:
33.1		 5c0oE-5c1iA:
98.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI
(Thermus
thermophilus) 		6 / 12 GLY A 103
GLY A 105
GLU A 125
ALA A 126
HIS A 130
LYS A 153
 None
 1.48A 5c0oF-5c1iA:
28.0		 5c0oF-5c1iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI
(Thermus
thermophilus) 		6 / 12 THR A  77
GLY A 105
GLY A 106
LEU A 107
ALA A 126
HIS A 130
 None
 0.77A 5c0oF-5c1iA:
28.0		 5c0oF-5c1iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI
(Thermus
thermophilus) 		6 / 12 THR A  77
GLY A 105
GLY A 106
LEU A 107
ALA A 126
LEU A 171
 None
 0.86A 5c0oF-5c1iA:
28.0		 5c0oF-5c1iA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI
(Thermus
thermophilus) 		6 / 12 GLY A 101
GLY A 103
GLY A 105
LEU A 107
ARG A 127
LEU A 154
 None
 0.68A 5c0oH-5c1iA:
30.4		 5c0oH-5c1iA:
98.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI
(Thermus
thermophilus) 		6 / 12 GLY A 101
GLY A 103
SER A 104
GLY A 105
LEU A 107
LEU A 154
 None
 0.83A 5c0oH-5c1iA:
30.4		 5c0oH-5c1iA:
98.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI
(Thermus
thermophilus) 		6 / 12 GLY A 101
SER A 104
GLY A 105
LEU A 107
LEU A 154
LEU A 171
 None
 0.82A 5c0oH-5c1iA:
30.4		 5c0oH-5c1iA:
98.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI
(Thermus
thermophilus) 		6 / 12 GLY A 101
SER A 104
GLY A 105
LEU A 154
GLU A 155
LEU A 171
 None
 0.94A 5c0oH-5c1iA:
30.4		 5c0oH-5c1iA:
98.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI
(Thermus
thermophilus) 		4 / 5 THR A  77
GLY A 106
GLU A 125
HIS A 130
 None
 0.58A 5c0oH-5c1iA:
31.7		 5c0oH-5c1iA:
98.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI
(Thermus
thermophilus) 		5 / 10 LEU A 191
ALA A 248
LEU A  88
MET A  85
LEU A  89
 None
 1.43A 5dxeB-5c1iA:
undetectable		 5dxeB-5c1iA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI
(Thermus
thermophilus) 		5 / 10 LEU A 191
ALA A 248
LEU A  88
MET A  85
LEU A  89
 None
 1.43A 5hyrA-5c1iA:
undetectable		 5hyrA-5c1iA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI
(Thermus
thermophilus) 		4 / 8 HIS A 150
ARG A  96
GLU A 122
GLU A 160
 None
 1.28A 6mn4B-5c1iA:
undetectable		 6mn4B-5c1iA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI
(Thermus
thermophilus) 		4 / 7 HIS A 150
ARG A  96
GLU A 122
GLU A 160
 None
 1.42A 6mn4F-5c1iA:
2.6		 6mn4F-5c1iA:
25.26