SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c1t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5c1t SMALL GTPASE EHRABX3
(Entamoeba
histolytica) 		4 / 6 ILE A 122
GLN A 121
ILE A 170
ASP A 173
 None
 1.16A 4w5qA-5c1tA:
3.5		 4w5qA-5c1tA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 5c1t SMALL GTPASE EHRABX3
(Entamoeba
histolytica) 		4 / 7 ILE A 112
PHE A 113
VAL A  91
ILE A 124
 None
 0.97A 4zzbC-5c1tA:
undetectable
4zzbD-5c1tA:
undetectable		 4zzbC-5c1tA:
22.95
4zzbD-5c1tA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 5c1t SMALL GTPASE EHRABX3
(Entamoeba
histolytica) 		4 / 8 ILE A 124
PHE A 153
GLN A 144
GLU A 143
 None
 1.17A 5dqyA-5c1tA:
undetectable		 5dqyA-5c1tA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)		 5c1t SMALL GTPASE EHRABX3
(Entamoeba
histolytica) 		5 / 12 ALA A 213
LEU A 184
TYR A 225
ASP A 281
THR A 195
 None
 1.42A 5vlmD-5c1tA:
undetectable		 5vlmD-5c1tA:
17.95