SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c2b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 5c2b SCFV 3B4 HEAVY CHAIN
3B4 LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ALA H 113
VAL L  35
TRP L  34
 None
 0.96A 1c4dA-5c2bH:
undetectable
1c4dB-5c2bH:
undetectable		 1c4dA-5c2bH:
9.40
1c4dB-5c2bH:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 5c2b SCFV 3B4 HEAVY CHAIN
3B4 LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 TRP L  34
ALA H 113
VAL L  35
 None
 0.96A 1c4dA-5c2bL:
undetectable
1c4dB-5c2bL:
undetectable		 1c4dA-5c2bL:
9.52
1c4dB-5c2bL:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 5c2b 3B4 LIGHT CHAIN
(Homo
sapiens) 		5 / 12 ASP L  87
LYS L 106
PRO L   7
GLY L 102
LEU L   4
 None
 1.22A 2nv4A-5c2bL:
undetectable		 2nv4A-5c2bL:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 5c2b 3B4 LIGHT CHAIN
(Homo
sapiens) 		4 / 6 ALA L   3
ASP L  28
LEU L   4
THR L   5
 None
 0.91A 3rozA-5c2bL:
undetectable		 3rozA-5c2bL:
17.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 5c2b SCFV 3B4 HEAVY CHAIN
(Homo
sapiens) 		3 / 3 TYR H  60
GLY H  66
THR H  69
 None
 0.15A 6cjkB-5c2bH:
19.6		 6cjkB-5c2bH:
36.22