SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c2c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		 5c2c FORM II RUBISCO
(Gallionella) 		4 / 7 HIS A 285
HIS A 321
HIS A 287
THR A 391
 KCX  A 191 ( 3.7A)
KCX  A 191 ( 3.5A)
KCX  A 191 ( 4.0A)
KCX  A 191 ( 2.9A)
 0.96A 1am6A-5c2cA:
undetectable		 1am6A-5c2cA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 5c2c FORM II RUBISCO
(Gallionella) 		4 / 4 GLY A 162
ASP A 188
GLY A 158
THR A 364
 None
 0.96A 1hxbB-5c2cA:
undetectable		 1hxbB-5c2cA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 5c2c FORM II RUBISCO
(Gallionella) 		5 / 12 THR A 391
ILE A 320
GLY A 319
THR A 363
ALA A 259
 KCX  A 191 ( 2.9A)
None
None
None
None
 0.99A 1nv8A-5c2cA:
undetectable		 1nv8A-5c2cA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 5c2c FORM II RUBISCO
(Gallionella) 		5 / 12 THR A 391
ILE A 320
GLY A 319
THR A 363
ALA A 259
 KCX  A 191 ( 2.9A)
None
None
None
None
 0.97A 1nv8B-5c2cA:
undetectable		 1nv8B-5c2cA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5c2c FORM II RUBISCO
(Gallionella) 		5 / 12 THR A 391
GLY A 393
GLY A 394
GLY A 370
PHE A 189
 KCX  A 191 ( 2.9A)
None
None
None
KCX  A 191 ( 4.0A)
 0.70A 1wg8A-5c2cA:
undetectable		 1wg8A-5c2cA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5c2c FORM II RUBISCO
(Gallionella) 		5 / 12 THR A 391
GLY A 393
GLY A 394
GLY A 370
PHE A 189
 KCX  A 191 ( 2.9A)
None
None
None
KCX  A 191 ( 4.0A)
 0.70A 1wg8B-5c2cA:
undetectable		 1wg8B-5c2cA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 5c2c FORM II RUBISCO
(Gallionella) 		3 / 3 ARG A 243
SER A 214
TYR A 212
 None
 0.69A 1x70A-5c2cA:
undetectable		 1x70A-5c2cA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 5c2c FORM II RUBISCO
(Gallionella) 		5 / 12 ALA A 392
GLY A 186
LEU A 185
LEU A 410
SER A 409
 None
 1.26A 2nv4A-5c2cA:
undetectable		 2nv4A-5c2cA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 5c2c FORM II RUBISCO
(Gallionella) 		5 / 12 ALA A 392
GLY A 186
LEU A 185
LEU A 410
SER A 409
 None
 1.21A 2nv4B-5c2cA:
undetectable		 2nv4B-5c2cA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 5c2c FORM II RUBISCO
(Gallionella) 		5 / 12 ALA A 392
ILE A 164
ASP A 193
VAL A 322
GLY A 323
 None
KCX  A 191 ( 4.1A)
MG  A 501 (-2.9A)
None
None
 0.85A 2qe6A-5c2cA:
undetectable		 2qe6A-5c2cA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 5c2c FORM II RUBISCO
(Gallionella) 		5 / 12 ALA A 392
ILE A 164
ASP A 193
VAL A 322
GLY A 323
 None
KCX  A 191 ( 4.1A)
MG  A 501 (-2.9A)
None
None
 0.92A 2qe6B-5c2cA:
undetectable		 2qe6B-5c2cA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 5c2c FORM II RUBISCO
(Gallionella) 		5 / 12 ALA A 413
PHE A 183
GLY A 395
THR A 163
LEU A 374
 None
 1.08A 2zifA-5c2cA:
undetectable		 2zifA-5c2cA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5c2c FORM II RUBISCO
(Gallionella) 		5 / 12 GLY A 326
GLY A 328
ILE A 339
GLY A 332
GLY A 333
 None
 1.02A 3axzA-5c2cA:
undetectable		 3axzA-5c2cA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5c2c FORM II RUBISCO
(Gallionella) 		4 / 4 SER A 396
GLY A 406
GLY A 162
GLY A 187
 None
 0.84A 3bogB-5c2cA:
undetectable
3bogD-5c2cA:
undetectable		 3bogB-5c2cA:
undetectable
3bogD-5c2cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CAJ_A_EZLA265_1
(CARBONIC ANHYDRASE 2)		 5c2c FORM II RUBISCO
(Gallionella) 		5 / 10 HIS A 285
HIS A 321
HIS A 287
PHE A 228
THR A 391
 KCX  A 191 ( 3.7A)
KCX  A 191 ( 3.5A)
KCX  A 191 ( 4.0A)
KCX  A 191 ( 4.5A)
KCX  A 191 ( 2.9A)
 1.22A 3cajA-5c2cA:
undetectable		 3cajA-5c2cA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		 5c2c FORM II RUBISCO
(Gallionella) 		5 / 10 HIS A 285
HIS A 321
HIS A 287
PHE A 228
THR A 391
 KCX  A 191 ( 3.7A)
KCX  A 191 ( 3.5A)
KCX  A 191 ( 4.0A)
KCX  A 191 ( 4.5A)
KCX  A 191 ( 2.9A)
 1.18A 3dazA-5c2cA:
undetectable		 3dazA-5c2cA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		 5c2c FORM II RUBISCO
(Gallionella) 		5 / 10 HIS A 285
HIS A 321
HIS A 287
PHE A 228
THR A 391
 KCX  A 191 ( 3.7A)
KCX  A 191 ( 3.5A)
KCX  A 191 ( 4.0A)
KCX  A 191 ( 4.5A)
KCX  A 191 ( 2.9A)
 1.19A 3dcsA-5c2cA:
undetectable		 3dcsA-5c2cA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 5c2c FORM II RUBISCO
(Gallionella) 		5 / 12 ILE A  74
ALA A  42
ILE A 118
ALA A 119
GLY A  35
 None
 1.08A 3nxuA-5c2cA:
undetectable		 3nxuA-5c2cA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 5c2c FORM II RUBISCO
(Gallionella) 		4 / 5 ILE A 366
THR A 364
THR A 363
SER A 318
 None
 1.15A 3snfA-5c2cA:
undetectable		 3snfA-5c2cA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 5c2c FORM II RUBISCO
(Gallionella) 		4 / 7 ASN A 372
ARG A 375
LEU A 376
GLY A 393
 None
 1.00A 4cp3A-5c2cA:
undetectable
4cp3B-5c2cA:
undetectable		 4cp3A-5c2cA:
13.51
4cp3B-5c2cA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5c2c FORM II RUBISCO
(Gallionella) 		5 / 12 ILE A 164
GLY A 369
GLY A 393
ILE A 367
HIS A 321
 KCX  A 191 ( 4.1A)
None
None
None
KCX  A 191 ( 3.5A)
 1.10A 4iv0B-5c2cA:
undetectable		 4iv0B-5c2cA:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5c2c FORM II RUBISCO
(Gallionella) 		4 / 5 THR A 250
LEU A 208
THR A 233
MET A 240
 None
 1.43A 4mbsB-5c2cA:
undetectable		 4mbsB-5c2cA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 5c2c FORM II RUBISCO
(Gallionella) 		4 / 6 ASP A 117
ASN A 112
ALA A  46
TYR A   7
 None
 1.05A 4mdaA-5c2cA:
undetectable		 4mdaA-5c2cA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5c2c FORM II RUBISCO
(Gallionella) 		5 / 12 ILE A 164
GLY A 369
GLY A 393
ILE A 367
HIS A 321
 KCX  A 191 ( 4.1A)
None
None
None
KCX  A 191 ( 3.5A)
 1.10A 4mwzA-5c2cA:
undetectable		 4mwzA-5c2cA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 5c2c FORM II RUBISCO
(Gallionella) 		5 / 12 HIS A 285
ILE A 366
HIS A 321
ALA A 289
ILE A 164
 KCX  A 191 ( 3.7A)
None
KCX  A 191 ( 3.5A)
None
KCX  A 191 ( 4.1A)
 1.15A 4rp8C-5c2cA:
undetectable		 4rp8C-5c2cA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 5c2c FORM II RUBISCO
(Gallionella) 		5 / 12 LEU A 146
THR A 391
ILE A 366
HIS A 285
ALA A 259
 None
KCX  A 191 ( 2.9A)
None
KCX  A 191 ( 3.7A)
None
 1.25A 4rp8C-5c2cA:
undetectable		 4rp8C-5c2cA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 5c2c FORM II RUBISCO
(Gallionella) 		5 / 12 LEU A 261
ILE A 366
HIS A 321
ALA A 289
ILE A 164
 KCX  A 191 ( 4.4A)
None
KCX  A 191 ( 3.5A)
None
KCX  A 191 ( 4.1A)
 1.24A 4rp8C-5c2cA:
undetectable		 4rp8C-5c2cA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 5c2c FORM II RUBISCO
(Gallionella) 		4 / 7 PHE A 440
ASP A 443
GLY A 394
GLY A 370
 None
 0.99A 5n9xA-5c2cA:
2.3		 5n9xA-5c2cA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 5c2c FORM II RUBISCO
(Gallionella) 		4 / 7 LEU A 171
ALA A 179
GLN A 182
GLN A 199
 None
 0.88A 6b89A-5c2cA:
undetectable		 6b89A-5c2cA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_0
(CYTOCHROME P450 1A1)		 5c2c FORM II RUBISCO
(Gallionella) 		5 / 12 ILE A 164
SER A 368
LEU A 169
ASP A 263
ILE A 366
 KCX  A 191 ( 4.1A)
KCX  A 191 ( 4.1A)
None
None
None
 1.23A 6dwnB-5c2cA:
undetectable		 6dwnB-5c2cA:
11.30