SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c2i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 5c2i ALR1585 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 MET A 212
ALA A  78
THR A 364
ARG A  41
LEU A  31
 None
 1.31A 1eiiA-5c2iA:
undetectable		 1eiiA-5c2iA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5c2i ALR1585 PROTEIN
(Nostoc
sp.
PCC
7120) 		3 / 3 ARG A 121
ASP A 242
ASN A 246
 None
 0.89A 1nbhA-5c2iA:
undetectable		 1nbhA-5c2iA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5c2i ALR1585 PROTEIN
(Nostoc
sp.
PCC
7120) 		3 / 3 ARG A 121
ASP A 242
ASN A 246
 None
 0.90A 1nbhD-5c2iA:
undetectable		 1nbhD-5c2iA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5c2i ALR1585 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 10 SER A 250
GLY A 252
VAL A 240
GLU A 241
SER A 461
 None
 1.15A 1pk7C-5c2iA:
undetectable		 1pk7C-5c2iA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5c2i ALR1585 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 10 SER A 250
GLY A 252
VAL A 240
GLU A 241
SER A 461
 None
 1.16A 1pk9A-5c2iA:
undetectable		 1pk9A-5c2iA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5c2i ALR1585 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 11 SER A 250
GLY A 252
VAL A 240
GLU A 241
SER A 461
 None
 1.14A 1pk9C-5c2iA:
undetectable		 1pk9C-5c2iA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5c2i ALR1585 PROTEIN
(Nostoc
sp.
PCC
7120) 		3 / 3 HIS A 329
ASP A 340
ASN A 316
 None
 0.88A 1wg8B-5c2iA:
undetectable		 1wg8B-5c2iA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5c2i ALR1585 PROTEIN
(Nostoc
sp.
PCC
7120) 		3 / 3 HIS A 361
ASP A 236
ASN A  10
 None
 0.82A 1wg8B-5c2iA:
undetectable		 1wg8B-5c2iA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 5c2i ALR1585 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 4 LEU A 278
PRO A 418
ILE A 289
LEU A 288
 None
 1.09A 1ya4B-5c2iA:
undetectable		 1ya4B-5c2iA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5c2i ALR1585 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 5 LEU A 255
GLY A 103
PRO A 460
ALA A 459
 None
 0.96A 2aohA-5c2iA:
undetectable		 2aohA-5c2iA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5c2i ALR1585 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 11 ILE A 289
GLY A 286
GLY A 291
HIS A 329
PRO A 420
 None
 1.16A 2y7kA-5c2iA:
undetectable		 2y7kA-5c2iA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5c2i ALR1585 PROTEIN
(Nostoc
sp.
PCC
7120) 		3 / 3 ASN A 316
ASN A 336
GLU A 358
 None
HEM  A 501 (-3.8A)
None
 0.90A 3kpdB-5c2iA:
undetectable		 3kpdB-5c2iA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 5c2i ALR1585 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 8 GLY A 423
GLN A 402
LEU A 447
ILE A 449
 None
HEM  A 501 (-4.4A)
None
HEM  A 501 (-4.1A)
 0.89A 3nbqB-5c2iA:
undetectable		 3nbqB-5c2iA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 5c2i ALR1585 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 LEU A 447
LEU A 260
GLY A 134
LEU A 133
GLN A 424
 None
HEM  A 501 ( 4.4A)
None
None
None
 1.12A 3tbgA-5c2iA:
undetectable		 3tbgA-5c2iA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 5c2i ALR1585 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 6 ARG A 366
GLN A 208
PHE A 211
LEU A  36
 None
 1.40A 3tgvB-5c2iA:
undetectable		 3tgvB-5c2iA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOT_A_CE3A205_1
(UNCHARACTERIZED
PROTEIN)		 5c2i ALR1585 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 GLY A 423
ASN A 407
ILE A 449
PHE A 387
ARG A 365
 None
None
HEM  A 501 (-4.1A)
HEM  A 501 (-4.0A)
HEM  A 501 (-2.7A)
 1.45A 4kotA-5c2iA:
undetectable		 4kotA-5c2iA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5c2i ALR1585 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 ARG A 268
GLN A 271
ALA A 294
ILE A 289
LEU A 421
 None
None
None
None
HEM  A 501 (-4.9A)
 1.22A 4r3aA-5c2iA:
undetectable		 4r3aA-5c2iA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5c2i ALR1585 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 8 MET A 451
ALA A 367
LEU A 386
PHE A  51
 None
 1.04A 4rkuA-5c2iA:
undetectable
4rkuJ-5c2iA:
undetectable		 4rkuA-5c2iA:
20.50
4rkuJ-5c2iA:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 5c2i ALR1585 PROTEIN
(Nostoc
sp.
PCC
7120) 		3 / 3 ARG A  41
GLN A  77
GLU A  80
 None
 0.75A 4tvtA-5c2iA:
undetectable		 4tvtA-5c2iA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 5c2i ALR1585 PROTEIN
(Nostoc
sp.
PCC
7120) 		3 / 3 GLU A 261
LYS A 259
ASN A 450
 None
GOL  A 502 (-2.9A)
None
 1.11A 4y1dA-5c2iA:
undetectable
4y1dD-5c2iA:
undetectable		 4y1dA-5c2iA:
15.60
4y1dD-5c2iA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 5c2i ALR1585 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 PHE A  48
LEU A 152
GLY A 454
LEU A 388
SER A  44
 None
 1.26A 4zbrA-5c2iA:
undetectable		 4zbrA-5c2iA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSH_B_ACTB401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5c2i ALR1585 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 5 ARG A 333
ARG A 343
LEU A 321
ASN A 316
 None
 1.37A 5cshB-5c2iA:
undetectable		 5cshB-5c2iA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5c2i ALR1585 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 4 ARG A 333
ARG A 343
LEU A 321
ASN A 316
 None
 1.36A 5cu6A-5c2iA:
0.0		 5cu6A-5c2iA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5c2i ALR1585 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 6 ALA A 151
VAL A 153
VAL A  59
HIS A 150
 None
 1.06A 5eckA-5c2iA:
undetectable		 5eckA-5c2iA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5c2i ALR1585 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 11 SER A 250
GLY A 252
VAL A 240
GLU A 241
SER A 461
 None
 1.18A 5i3cC-5c2iA:
undetectable		 5i3cC-5c2iA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5c2i ALR1585 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 4 ARG A 333
ARG A 343
LEU A 321
ASN A 316
 None
 1.37A 5os7A-5c2iA:
0.0		 5os7A-5c2iA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5c2i ALR1585 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 5 ARG A 333
ARG A 343
LEU A 321
ASN A 316
 None
 1.38A 5osrA-5c2iA:
undetectable		 5osrA-5c2iA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5c2i ALR1585 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 5 ARG A 333
ARG A 343
LEU A 321
ASN A 316
 None
 1.36A 5otrA-5c2iA:
0.0		 5otrA-5c2iA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5c2i ALR1585 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 GLY A 205
TYR A 370
PHE A  48
GLY A 454
LEU A 260
 HEM  A 501 (-3.4A)
GOL  A 502 (-4.4A)
None
None
HEM  A 501 ( 4.4A)
 1.19A 6e8qA-5c2iA:
undetectable		 6e8qA-5c2iA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 5c2i ALR1585 PROTEIN
(Nostoc
sp.
PCC
7120) 		3 / 3 THR A 346
ALA A 354
LYS A 356
 None
 0.36A 6fgcA-5c2iA:
undetectable		 6fgcA-5c2iA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 5c2i ALR1585 PROTEIN
(Nostoc
sp.
PCC
7120) 		3 / 3 THR A 346
ALA A 354
LYS A 356
 None
 0.35A 6fgdA-5c2iA:
undetectable		 6fgdA-5c2iA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5c2i ALR1585 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 4 ARG A 333
ARG A 343
LEU A 321
ASN A 316
 None
 1.37A 6gmdB-5c2iA:
0.0		 6gmdB-5c2iA:
21.47