SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c2k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_B_DVAB6_0
(GRAMICIDIN A)		 5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 4 VAL A  79
TRP A  58
ALA A  56
VAL A   9
 None
 1.39A 1gmkA-5c2kA:
undetectable
1gmkB-5c2kA:
undetectable		 1gmkA-5c2kA:
3.06
1gmkB-5c2kA:
3.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ALA A  61
VAL A  11
TRP A  99
 None
 0.93A 1jnoA-5c2kA:
undetectable		 1jnoA-5c2kA:
3.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ALA A  61
VAL A  11
TRP A  99
 None
 0.93A 1jnoB-5c2kA:
undetectable		 1jnoB-5c2kA:
3.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ALA A  61
VAL A  11
TRP A  99
 None
 0.94A 1ng8A-5c2kA:
undetectable		 1ng8A-5c2kA:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ALA A  61
VAL A  11
TRP A  99
 None
 0.94A 1ng8B-5c2kA:
undetectable		 1ng8B-5c2kA:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_B_RABB646_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 9 MET A 353
GLY A 363
VAL A 390
GLU A 391
ILE A 366
 None
 1.37A 1pw7B-5c2kA:
2.3		 1pw7B-5c2kA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 12 TYR A  34
VAL A 361
ASP A  65
HIS A 278
GLY A  17
 GDP  A 503 (-4.7A)
None
None
None
GDP  A 503 (-3.2A)
 1.45A 1xvaA-5c2kA:
undetectable		 1xvaA-5c2kA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 8 SER A  88
ASP A  90
SER A  91
SER A  85
 None
 1.12A 2cmlB-5c2kA:
undetectable		 2cmlB-5c2kA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 7 MET A 212
ARG A 299
PRO A 225
MET A 223
 None
 1.25A 2hrcA-5c2kA:
3.2		 2hrcA-5c2kA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 7 MET A 212
ARG A 299
PRO A 225
MET A 223
 None
 1.18A 2pnjB-5c2kA:
2.4		 2pnjB-5c2kA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 8 SER A 218
ILE A 224
ASP A 333
ARG A 332
 None
 1.12A 2v57A-5c2kA:
undetectable		 2v57A-5c2kA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 8 SER A 218
ILE A 224
ASP A 333
ARG A 332
 None
 1.11A 2v57C-5c2kA:
undetectable		 2v57C-5c2kA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 6 MET A 212
ARG A 299
PRO A 225
MET A 223
 None
 1.19A 3aqiA-5c2kA:
4.6		 3aqiA-5c2kA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ARG A 247
GLN A  63
GLY A  12
GLY A  62
ASN A  94
 GDP  A 503 ( 3.5A)
AF3  A 502 (-3.2A)
None
AF3  A 502 (-3.4A)
None
 1.21A 3sxjA-5c2kA:
undetectable		 3sxjA-5c2kA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ARG A 247
GLN A  63
GLY A  12
GLY A  62
ASN A  94
 GDP  A 503 ( 3.5A)
AF3  A 502 (-3.2A)
None
AF3  A 502 (-3.4A)
None
 1.22A 3sxjB-5c2kA:
undetectable		 3sxjB-5c2kA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ARG A 247
GLN A  63
GLY A  12
GLY A  62
ASN A  94
 GDP  A 503 ( 3.5A)
AF3  A 502 (-3.2A)
None
AF3  A 502 (-3.4A)
None
 1.23A 3t7sB-5c2kA:
undetectable		 3t7sB-5c2kA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ARG A 247
GLN A  63
GLY A  12
GLY A  62
ASN A  94
 GDP  A 503 ( 3.5A)
AF3  A 502 (-3.2A)
None
AF3  A 502 (-3.4A)
None
 1.21A 3t7sD-5c2kA:
undetectable		 3t7sD-5c2kA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 10 MET A 353
GLY A 363
VAL A 390
GLU A 391
ILE A 366
 None
 1.25A 3uayA-5c2kA:
4.3		 3uayA-5c2kA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 4 SER A  85
ASP A 249
ASP A  65
ALA A  15
 None
None
None
GDP  A 503 ( 4.2A)
 1.48A 3uj6A-5c2kA:
undetectable		 3uj6A-5c2kA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 7 PRO A  36
GLN A  63
ARG A 247
GLY A  14
 AF3  A 502 (-4.5A)
AF3  A 502 (-3.2A)
GDP  A 503 ( 3.5A)
AF3  A 502 (-3.3A)
 0.90A 4a3uB-5c2kA:
undetectable		 4a3uB-5c2kA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 5 MET A 212
ARG A 299
PRO A 225
MET A 223
 None
 1.20A 4klaB-5c2kA:
2.0		 4klaB-5c2kA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 6 GLU A  93
ASP A  13
ASP A 249
GLU A  64
 None
 1.14A 4ntxA-5c2kA:
undetectable
4ntxC-5c2kA:
undetectable		 4ntxA-5c2kA:
20.74
4ntxC-5c2kA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 280
HIS A 230
VAL A 268
PHE A 262
VAL A 255
 None
 1.22A 5n0rA-5c2kA:
undetectable		 5n0rA-5c2kA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 280
HIS A 230
VAL A 268
PHE A 262
VAL A 255
 None
 1.16A 5n0wA-5c2kA:
undetectable		 5n0wA-5c2kA:
22.63