SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c2m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 5c2m PREDICTED PROTEIN
(Nematostella
vectensis) 		4 / 7 LEU A 225
LEU A 191
GLY A 189
LEU A 167
 None
 0.81A 1gtiB-5c2mA:
undetectable		 1gtiB-5c2mA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 5c2m PREDICTED PROTEIN
(Nematostella
vectensis) 		3 / 3 ALA A  36
VAL A 232
TRP A 237
 None
 0.92A 1nrmA-5c2mA:
undetectable		 1nrmA-5c2mA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 5c2m PREDICTED PROTEIN
(Nematostella
vectensis) 		3 / 3 ALA A  36
VAL A 232
TRP A 237
 None
 0.92A 1nrmB-5c2mA:
undetectable		 1nrmB-5c2mA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5c2m PREDICTED PROTEIN
(Nematostella
vectensis) 		3 / 3 LYS A 174
TYR A 113
PRO A 172
 None
 1.45A 2j9cC-5c2mA:
undetectable		 2j9cC-5c2mA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5c2m PREDICTED PROTEIN
(Nematostella
vectensis) 		5 / 12 LEU A  64
GLY A  75
LEU A  56
ALA A  90
GLY A  46
 None
 0.98A 2vmyA-5c2mA:
undetectable		 2vmyA-5c2mA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 5c2m PREDICTED PROTEIN
(Nematostella
vectensis) 		4 / 8 ASN A 230
LYS A 215
LYS A 216
TRP A 192
 None
 1.39A 3bjwD-5c2mA:
undetectable		 3bjwD-5c2mA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5c2m PREDICTED PROTEIN
(Nematostella
vectensis) 		4 / 7 TRP A 192
TRP A 224
HIS A 227
ASN A 230
 None
 1.48A 4a3uA-5c2mA:
undetectable		 4a3uA-5c2mA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 5c2m PREDICTED PROTEIN
(Nematostella
vectensis) 		5 / 11 HIS A 168
LEU A 139
ASP A 118
GLY A 146
PHE A 148
 None
 1.10A 4fogA-5c2mA:
undetectable		 4fogA-5c2mA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 5c2m PREDICTED PROTEIN
(Nematostella
vectensis) 		5 / 11 HIS A 168
LEU A 139
ASP A 118
GLY A 146
PHE A 148
 None
 1.12A 4fogC-5c2mA:
undetectable		 4fogC-5c2mA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 5c2m PREDICTED PROTEIN
(Nematostella
vectensis) 		3 / 3 TYR A 160
LYS A 158
LYS A 169
 None
 0.95A 5dbyA-5c2mA:
undetectable		 5dbyA-5c2mA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 5c2m PREDICTED PROTEIN
(Nematostella
vectensis) 		3 / 3 GLU A  32
TRP A  38
ASN A  14
 None
 1.08A 5dv4A-5c2mA:
undetectable		 5dv4A-5c2mA:
20.15