SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c2u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B8J_B_ADNB331_1
(CLASS B ACID
PHOSPHATASE)		 5c2u NANOBODY
(Camelus
dromedarius) 		5 / 10 PHE B  64
LEU B  77
GLY B  43
ARG B  34
TYR B  56
 None
 1.37A 2b8jB-5c2uB:
undetectable		 2b8jB-5c2uB:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5c2u NANOBODY
NUP54
(Camelus
dromedarius;
Xenopus
laevis) 		3 / 3 ARG B  97
GLU A 315
SER B  53
 None
 0.75A 2xctD-5c2uB:
undetectable		 2xctD-5c2uB:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 5c2u NANOBODY
NUP54
(Camelus
dromedarius;
Xenopus
laevis) 		5 / 12 GLN A 233
PHE A 223
ILE A 270
LEU A 241
TYR B 104
 None
 1.19A 3ia4C-5c2uA:
undetectable		 3ia4C-5c2uA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5c2u NANOBODY
(Camelus
dromedarius) 		5 / 12 LEU B  17
TYR B  90
GLY B 117
GLY B   7
ALA B  93
 None
 1.13A 3ou6A-5c2uB:
undetectable		 3ou6A-5c2uB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5c2u NANOBODY
(Camelus
dromedarius) 		5 / 12 LEU B  17
TYR B  90
GLY B 117
GLY B   7
ALA B  93
 None
 1.14A 3ou6B-5c2uB:
undetectable		 3ou6B-5c2uB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5c2u NUP54
(Xenopus
laevis) 		5 / 12 ASN A 224
ALA A 300
SER A 304
GLY A 306
LEU A 305
 None
 0.89A 4e1gA-5c2uA:
undetectable		 4e1gA-5c2uA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_1
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 5c2u NUP54
NANOBODY
(Xenopus
laevis;
Camelus
dromedarius) 		4 / 5 GLN B  98
GLU A 294
ASP B  51
TYR B 105
 None
 1.44A 6iftA-5c2uB:
undetectable		 6iftA-5c2uB:
18.69