SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c2w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 5c2w HYPOTHETICAL (DI
HEME) PROTEIN
(Candidatus
Kuenenia
stuttgartiensis) 		5 / 8 GLU C 275
GLY C 274
SER C 269
ASP C 320
THR C 325
 None
 1.28A 1m4iA-5c2wC:
undetectable		 1m4iA-5c2wC:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 5c2w HYPOTHETICAL (DI
HEME) PROTEIN
(Candidatus
Kuenenia
stuttgartiensis) 		5 / 11 LYS C 131
ASP C 312
THR C 250
GLY C 251
ASP C 290
 HEC  C 404 (-4.2A)
None
HEC  C 405 (-3.1A)
None
None
 1.43A 3sfuC-5c2wC:
undetectable		 3sfuC-5c2wC:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 5c2w HYPOTHETICAL (DI
HEME) PROTEIN
(Candidatus
Kuenenia
stuttgartiensis) 		4 / 5 SER C  99
GLY C  98
TRP C  94
ASP C  91
 None
 1.20A 3w9tB-5c2wC:
undetectable		 3w9tB-5c2wC:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 5c2w HYPOTHETICAL (DI
HEME) PROTEIN
(Candidatus
Kuenenia
stuttgartiensis) 		4 / 5 SER C  99
GLY C  98
TRP C  94
ASP C  91
 None
 1.21A 3w9tC-5c2wC:
undetectable		 3w9tC-5c2wC:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 5c2w HYPOTHETICAL (DI
HEME) PROTEIN
(Candidatus
Kuenenia
stuttgartiensis) 		4 / 5 SER C  99
GLY C  98
TRP C  94
ASP C  91
 None
 1.21A 3w9tD-5c2wC:
undetectable		 3w9tD-5c2wC:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5c2w HYPOTHETICAL (DI
HEME) PROTEIN
(Candidatus
Kuenenia
stuttgartiensis) 		4 / 6 GLU C 219
TYR C 349
LEU C 350
PHE C 218
 None
None
HEC  C 405 ( 4.9A)
None
 1.23A 4twdB-5c2wC:
undetectable
4twdC-5c2wC:
undetectable		 4twdB-5c2wC:
23.75
4twdC-5c2wC:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5c2w HYPOTHETICAL (DI
HEME) PROTEIN
(Candidatus
Kuenenia
stuttgartiensis) 		4 / 6 GLU C 219
TYR C 349
LEU C 350
PHE C 218
 None
None
HEC  C 405 ( 4.9A)
None
 1.19A 4twdD-5c2wC:
undetectable
4twdE-5c2wC:
undetectable		 4twdD-5c2wC:
23.75
4twdE-5c2wC:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5c2w HYPOTHETICAL (DI
HEME) PROTEIN
(Candidatus
Kuenenia
stuttgartiensis) 		4 / 6 GLU C 219
TYR C 349
LEU C 350
PHE C 218
 None
None
HEC  C 405 ( 4.9A)
None
 1.26A 4twdF-5c2wC:
undetectable
4twdG-5c2wC:
undetectable		 4twdF-5c2wC:
23.75
4twdG-5c2wC:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5c2w HYPOTHETICAL (DI
HEME) PROTEIN
(Candidatus
Kuenenia
stuttgartiensis) 		4 / 6 GLU C 219
TYR C 349
LEU C 350
PHE C 218
 None
None
HEC  C 405 ( 4.9A)
None
 1.16A 4twdI-5c2wC:
undetectable
4twdJ-5c2wC:
undetectable		 4twdI-5c2wC:
23.75
4twdJ-5c2wC:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 5c2w HYPOTHETICAL (DI
HEME) PROTEIN
(Candidatus
Kuenenia
stuttgartiensis) 		4 / 8 ARG C 143
ASP C 168
PHE C 171
ASP C 121
 HEC  C 404 (-4.2A)
HEC  C 404 (-4.1A)
None
None
 1.14A 4xqgA-5c2wC:
undetectable		 4xqgA-5c2wC:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 5c2w HYPOTHETICAL (DI
HEME) PROTEIN
(Candidatus
Kuenenia
stuttgartiensis) 		4 / 8 ARG C 143
ASP C 168
PHE C 171
ASP C 121
 HEC  C 404 (-4.2A)
HEC  C 404 (-4.1A)
None
None
 1.13A 4xqgB-5c2wC:
undetectable		 4xqgB-5c2wC:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5c2w HYPOTHETICAL (DI
HEME) PROTEIN
(Candidatus
Kuenenia
stuttgartiensis) 		4 / 4 GLY C 197
ALA C 352
MET C 234
THR C 208
 None
 1.31A 5n0sB-5c2wC:
undetectable		 5n0sB-5c2wC:
23.43