SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c2y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1G60_A_SAMA500_0 (ADENINE-SPECIFIC METHYLTRANSFERASE MBOIIA)	5c2y	RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RTR1 (Saccharomyces cerevisiae)	5 / 12	ASN A 70 CYH A 38 ASP A 6 GLY A 0 SER A -1	None	1.10A	1g60A-5c2yA: undetectable	1g60A-5c2yA: 20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OPX_A_DXCA1002_0 (ALDEHYDE DEHYDROGENASE A)	5c2y	RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RTR1 (Saccharomyces cerevisiae)	3 / 3	GLY A 74 ARG A 67 TYR A 111	None	0.86A	2opxA-5c2yA: undetectable	2opxA-5c2yA: 17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RLF_D_RIMD499_1 (MATRIX PROTEIN 2)	5c2y	RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RTR1 (Saccharomyces cerevisiae)	4 / 6	ILE A 7 ARG A 53 LEU A 51 LEU A 12	None	1.05A	2rlfA-5c2yA: undetectable 2rlfD-5c2yA: undetectable	2rlfA-5c2yA: 12.24 2rlfD-5c2yA: 12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QKN_A_JMSA602_1 (ALPHA-KETOGLUTARATE- DEPENDENT DIOXYGENASE FTO)	5c2y	RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RTR1 (Saccharomyces cerevisiae)	4 / 8	LEU A 12 PRO A 14 LEU A 140 HIS A 18	None None None GOL A 304 (-3.5A)	1.19A	4qknA-5c2yA: undetectable	4qknA-5c2yA: 18.45

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1G60_A_SAMA500_0","ADENINE-SPECIFIC METHYLTRANSFERASE MBOIIA","5c2y","RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RTR1","Saccharomyces cerevisiae",5,"ASN A  70;CYH A  38;ASP A   6;GLY A   0;SER A  -1","None","1.10A","1g60A-5c2yA:undetectable","1g60A-5c2yA:20.99"],["2OPX_A_DXCA1002_0","ALDEHYDE DEHYDROGENASE A","5c2y","RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RTR1","Saccharomyces cerevisiae",3,"GLY A  74;ARG A  67;TYR A 111","None","0.86A","2opxA-5c2yA:undetectable","2opxA-5c2yA:17.27"],["2RLF_D_RIMD499_1","MATRIX PROTEIN 2;MATRIX PROTEIN 2","5c2y","RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RTR1","Saccharomyces cerevisiae",4,"ILE A   7;ARG A  53;LEU A  51;LEU A  12","None","1.05A","2rlfA-5c2yA:undetectable;2rlfD-5c2yA:undetectable","2rlfA-5c2yA:12.24;2rlfD-5c2yA:12.24"],["4QKN_A_JMSA602_1","ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO","5c2y","RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RTR1","Saccharomyces cerevisiae",4,"LEU A  12;PRO A  14;LEU A 140;HIS A  18","None;None;None;GOL A 304 (-3.5A)","1.19A","4qknA-5c2yA:undetectable","4qknA-5c2yA:18.45"]]