SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c2z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 5c2z EXFOLIATIVE TOXIN D2
(Staphylococcus
aureus) 		3 / 3 THR A 192
PRO A 187
THR A 190
 None
 0.94A 1dscC-5c2zA:
undetectable		 1dscC-5c2zA:
5.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 5c2z EXFOLIATIVE TOXIN D2
(Staphylococcus
aureus) 		5 / 12 THR A  72
GLY A  83
GLY A 220
VAL A  91
GLY A 113
 None
 0.96A 1n2xB-5c2zA:
undetectable		 1n2xB-5c2zA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 5c2z EXFOLIATIVE TOXIN D2
(Staphylococcus
aureus) 		3 / 3 ARG A  99
LEU A 100
THR A  93
 None
 0.87A 3oxcA-5c2zA:
undetectable		 3oxcA-5c2zA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 5c2z EXFOLIATIVE TOXIN D2
(Staphylococcus
aureus) 		5 / 12 GLY A 217
ALA A  81
GLY A  71
VAL A  70
ILE A  97
 None
 0.94A 3oxxC-5c2zA:
undetectable		 3oxxC-5c2zA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 5c2z EXFOLIATIVE TOXIN D2
(Staphylococcus
aureus) 		5 / 12 LEU A 266
LEU A 146
ASN A  94
ILE A  86
ILE A 148
 None
 1.06A 3ut5B-5c2zA:
undetectable		 3ut5B-5c2zA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5c2z EXFOLIATIVE TOXIN D2
(Staphylococcus
aureus) 		5 / 12 GLY A  83
GLY A  71
THR A  93
ILE A 148
LEU A 270
 None
 1.19A 4n48A-5c2zA:
undetectable		 4n48A-5c2zA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5c2z EXFOLIATIVE TOXIN D2
(Staphylococcus
aureus) 		5 / 12 GLY A  83
GLY A  71
THR A  93
ILE A 148
LEU A 270
 None
 1.21A 4n48B-5c2zA:
undetectable		 4n48B-5c2zA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5c2z EXFOLIATIVE TOXIN D2
(Staphylococcus
aureus) 		4 / 5 ALA A 212
TYR A 213
HIS A 193
PRO A 216
 None
 1.25A 4ze2A-5c2zA:
undetectable		 4ze2A-5c2zA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 5c2z EXFOLIATIVE TOXIN D2
(Staphylococcus
aureus) 		5 / 12 LEU A 266
LEU A 146
ASN A  94
ILE A  86
ILE A 148
 None
 1.01A 5itzB-5c2zA:
undetectable		 5itzB-5c2zA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 5c2z EXFOLIATIVE TOXIN D2
(Staphylococcus
aureus) 		5 / 12 LEU A 266
LEU A 146
ASN A  94
ILE A  86
ILE A 148
 None
 1.05A 5mioB-5c2zA:
undetectable		 5mioB-5c2zA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 5c2z EXFOLIATIVE TOXIN D2
(Staphylococcus
aureus) 		5 / 11 PHE A 224
SER A  69
ALA A 167
THR A  93
ALA A  81
 None
 1.31A 6efnA-5c2zA:
undetectable		 6efnA-5c2zA:
20.80