SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c3c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5c3c CBBQ/NIRQ/NORQ
DOMAIN PROTEIN
(Halothiobacillus
neapolitanus) 		4 / 6 ILE A 108
MET A  70
THR A  71
LEU A  75
 None
 1.00A 2einN-5c3cA:
2.4
2einW-5c3cA:
undetectable		 2einN-5c3cA:
18.92
2einW-5c3cA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 5c3c CBBQ/NIRQ/NORQ
DOMAIN PROTEIN
(Halothiobacillus
neapolitanus) 		5 / 12 ALA A 258
ASP A 257
ASP A 254
ILE A 249
ALA A 207
 None
 1.02A 3n3iA-5c3cA:
undetectable		 3n3iA-5c3cA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 5c3c CBBQ/NIRQ/NORQ
DOMAIN PROTEIN
(Halothiobacillus
neapolitanus) 		4 / 6 LEU A 245
ALA A 204
LEU A 223
SER A 220
 None
None
None
ADP  A 301 ( 4.6A)
 1.20A 4d7bB-5c3cA:
undetectable		 4d7bB-5c3cA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5c3c CBBQ/NIRQ/NORQ
DOMAIN PROTEIN
(Halothiobacillus
neapolitanus) 		4 / 5 GLU A  24
GLU A  22
TYR A  16
PHE A  49
 None
None
ADP  A 301 (-3.6A)
None
 1.44A 4twdA-5c3cA:
undetectable
4twdE-5c3cA:
undetectable		 4twdA-5c3cA:
19.45
4twdE-5c3cA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5c3c CBBQ/NIRQ/NORQ
DOMAIN PROTEIN
(Halothiobacillus
neapolitanus) 		4 / 5 GLU A  24
GLU A  22
TYR A  16
PHE A  49
 None
None
ADP  A 301 (-3.6A)
None
 1.44A 4twdH-5c3cA:
undetectable
4twdI-5c3cA:
undetectable		 4twdH-5c3cA:
19.45
4twdI-5c3cA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 5c3c CBBQ/NIRQ/NORQ
DOMAIN PROTEIN
(Halothiobacillus
neapolitanus) 		4 / 6 LEU A 245
ALA A 204
LEU A 223
SER A 220
 None
None
None
ADP  A 301 ( 4.6A)
 1.15A 5l4iB-5c3cA:
undetectable		 5l4iB-5c3cA:
22.91